1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	S	R	T	L	R	L	L	V	V	S	A	L	A	T	L	S	G	L	G	T	P	V	A	H	A	V	S	P	P	P	I	D	E	R	W	L	P	E	S	A	L	P	A	P	P	R	P	T	V	Q	R	E	V	C	T	E	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?			?				?	?		?	?	?	?	?	?	?	?	?	?			?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	E	S	G	R	A	F	G	R	A	E	R	S	A	Q	L	A	D	L	D	Q	V	W	R	L	T	R	G	A	G	Q	R	V	A	V	I	D	T	G	V	A	R	H	R	R	L	P	K	V	V	A	G	G	D	Y	V	F	T	G
Secondary structure
SS confidence
Disorder						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	G	T	A	D	C	D	A	H	G	T	L	V	A	G	I	I	A	A	A	P	D	A	Q	S	D	N	F	S	G	V	A	P	D	V	T	L	I	S	I	R	Q	S	S	S	K	F	A	P	V	G	D	P	S	S	T	G	V	G	D
Secondary structure
SS confidence
Disorder			?	?	?	?															?				?	?	?	?																				?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	D	T	M	A	K	A	V	R	T	A	A	D	L	G	A	S	V	I	N	I	S	S	I	A	C	V	P	A	A	A	A	P	D	D	R	A	L	G	A	A	L	A	Y	A	V	D	V	K	N	A	V	I	V	A	A	A	G	N	T
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	G	A	A	Q	C	P	P	Q	A	P	G	V	T	R	D	S	V	T	V	A	V	S	P	A	W	Y	D	D	Y	V	L	T	V	G	S	V	N	A	Q	G	E	P	S	A	F	T	L	A	G	P	W	V	D	V	A	A	T	G	E
Secondary structure
SS confidence
Disorder					?	?											?	?	?		?																			?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	V	T	S	L	S	P	F	G	D	G	T	V	N	R	L	G	G	Q	H	G	S	I	P	I	S	G	T	S	Y	A	A	P	V	V	S	G	L	A	A	L	I	R	A	R	F	P	T	L	T	A	R	Q	V	M	Q	R	I	E	S
Secondary structure
SS confidence
Disorder																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	A	H	H	P	P	A	G	W	D	P	L	V	G	N	G	T	V	D	A	L	A	A	V	S	S	D	S	I	P	Q	A	G	T	A	T	S	D	P	A	P	V	A	V	P	V	P	R	R	S	T	P	G	P	S	D	R	R	A	L
Secondary structure
SS confidence
Disorder						?		?																	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Sequence		H	T	A	F	A	G	A	A	I	C	L	L	A	L	M	A	T	L	A	T	A	S	R	R	L	R	P	G	R	N	G	I	A	G	D
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 21%) Beta strand ( 17%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 4j94 chain A Region: 29 - 398 Aligned: 367 Modelled: 370 Confidence: 100.0% Identity: 42% PDB header:hydrolase Chain: A: PDB Molecule:membrane-anchored mycosin mycp1; PDBTitle: crystal structure of mycp1 from the esx-1 type vii secretion system Phyre2 PDB 1r6v chain A Region: 11 - 392 Aligned: 353 Modelled: 362 Confidence: 100.0% Identity: 25% Fold: Subtilisin-like Superfamily: Subtilisin-like Family: Subtilases Phyre2 PDB 4tr2 chain A Region: 64 - 384 Aligned: 292 Modelled: 321 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:subtilisin-like 1 serine protease; PDBTitle: crystal structure of pvsub1 Phyre2 PDB 4kg7 chain A Region: 29 - 387 Aligned: 357 Modelled: 357 Confidence: 100.0% Identity: 47% PDB header:hydrolase Chain: A: PDB Molecule:peptidase s8 and s53, subtilisin, kexin, sedolisin; PDBTitle: structure of mycp3 protease from the type vii (esx-3) secretion2 system. Phyre2 PDB 2oxa chain A Region: 44 - 396 Aligned: 342 Modelled: 351 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:extracellular serine protease; PDBTitle: crystal structure of serine protease of aeromonas sobria Phyre2 PDB 3vta chain B Region: 76 - 393 Aligned: 303 Modelled: 314 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:cucumisin; PDBTitle: crystal structure of cucumisin, a subtilisin-like endoprotease from2 cucumis melo l Phyre2 PDB 1r64 chain A Region: 65 - 384 Aligned: 287 Modelled: 307 Confidence: 100.0% Identity: 22% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:kexin; PDBTitle: the 2.2 a crystal structure of kex2 protease in complex with ac-arg-2 glu-lys-boroarg peptidyl boronic acid inhibitor Phyre2 PDB 1p8j chain B Region: 64 - 384 Aligned: 290 Modelled: 291 Confidence: 100.0% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:furin precursor; PDBTitle: crystal structure of the proprotein convertase furin Phyre2 PDB 1xf1 chain A Region: 75 - 384 Aligned: 285 Modelled: 310 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:c5a peptidase; PDBTitle: structure of c5a peptidase- a key virulence factor from2 streptococcus Phyre2 PDB 3i74 chain B Region: 75 - 393 Aligned: 287 Modelled: 298 Confidence: 100.0% Identity: 27% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:subtilisin-like protease; PDBTitle: crystal structure of the plant subtilisin-like protease sbt3 in2 complex with a chloromethylketone inhibitor Phyre2 PDB 5xyr chain A Region: 67 - 384 Aligned: 294 Modelled: 315 Confidence: 100.0% Identity: 28% PDB header:lyase Chain: A: PDB Molecule:chemokine protease c; PDBTitle: crystal structure of a serine protease from streptococcus species Phyre2 PDB 5xxz chain B Region: 67 - 388 Aligned: 285 Modelled: 289 Confidence: 100.0% Identity: 26% PDB header:lyase Chain: B: PDB Molecule:chemokine protease c; PDBTitle: crystal structure of a serine protease from streptococcus species Phyre2 PDB 3qfh chain E Region: 52 - 392 Aligned: 325 Modelled: 325 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: E: PDB Molecule:epidermin leader peptide processing serine protease epip; PDBTitle: 2.05 angstrom resolution crystal structure of epidermin leader peptide2 processing serine protease (epip) from staphylococcus aureus. Phyre2 PDB 3t41 chain B Region: 52 - 387 Aligned: 320 Modelled: 325 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:epidermin leader peptide processing serine protease epip; PDBTitle: 1.95 angstrom resolution crystal structure of epidermin leader peptide2 processing serine protease (epip) s393a mutant from staphylococcus3 aureus Phyre2 PDB 3bps chain A Region: 72 - 398 Aligned: 274 Modelled: 295 Confidence: 100.0% Identity: 25% PDB header:hydrolase/lipid transport Chain: A: PDB Molecule:proprotein convertase subtilisin/kexin type 9; PDBTitle: pcsk9:egf-a complex Phyre2 PDB 6mw4 chain A Region: 66 - 384 Aligned: 300 Modelled: 319 Confidence: 100.0% Identity: 21% PDB header:signaling protein Chain: A: PDB Molecule:putative germination-specific protease; PDBTitle: structure of pseudoprotease cspc from clostridioides difficile Phyre2 PDB 2iy9 chain A Region: 71 - 384 Aligned: 286 Modelled: 314 Confidence: 100.0% Identity: 25% PDB header:toxin Chain: A: PDB Molecule:suba; PDBTitle: crystal structure of the a-subunit of the ab5 toxin from e.2 coli Phyre2 PDB 4mzd chain A Region: 67 - 388 Aligned: 298 Modelled: 322 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:nisin leader peptide-processing serine protease nisp; PDBTitle: high resolution crystal structure of the nisin leader peptidase nisp2 from lactococcus lactis Phyre2 PDB 5vlp chain A Region: 88 - 364 Aligned: 227 Modelled: 244 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:proprotein convertase subtilisin/kexin type 9; PDBTitle: pcsk9 complex with ldlr antagonist peptide and fab7g7 Phyre2 PDB 1p8j chain A domain 2 Region: 64 - 384 Aligned: 290 Modelled: 308 Confidence: 100.0% Identity: 19% Fold: Subtilisin-like Superfamily: Subtilisin-like Family: Subtilases Phyre2 1 c4j94A_ 2 d1r6va_ 3 c4tr2A_ 4 c4kg7A_ 5 c2oxaA_ 6 c3vtaB_ 7 c1r64A_ 8 c1p8jB_ 9 c1xf1A_ 10 c3i74B_ 11 c5xyrA_ 12 c5xxzB_ 13 c3qfhE_ 14 c3t41B_ 15 c3bpsA_ 16 c6mw4A_ 17 c2iy9A_ 18 c4mzdA_ 19 c5vlpA_ 20 d1p8ja2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84