1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	Q	R	T	V	A	G	D	L	D	A	A	L	T	T	I	F	R	T	P	V	R	L	R	A	A	G	R	T	D	A	G	V	H	A	S	G	Q	V	A	H	V	D	V	P	A	D	A	L	P	N	A	Y	P	R	A	G	H	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																															?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	D	P	E	F	L	P	L	L	R	R	L	G	R	F	L	P	A	D	V	R	I	L	D	I	T	R	A	P	A	G	F	D	A	R	F	S	A	L	R	R	H	Y	V	Y	R	L	S	T	A	P	Y	G	V	E	P	Q	Q	A	R
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	I	T	A	W	P	R	E	L	D	L	D	A	M	T	A	A	S	R	D	L	M	G	L	H	D	F	A	A	F	C	R	H	R	E	G	A	T	T	I	R	D	L	Q	R	L	D	W	S	R	A	G	T	L	V	T	A	H	V	T
Secondary structure
SS confidence
Disorder																																			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	D	A	F	C	W	S	M	V	R	S	L	V	G	A	L	L	A	V	G	E	H	R	R	A	T	T	W	C	R	E	L	L	T	A	T	G	R	S	S	D	F	A	V	A	P	A	H	G	L	T	L	I	Q	V	D	Y	P	P	D
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.
Sequence		D	Q	L	A	S	R	N	L	V	T	R	D	V	R	S	G
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 30%) Beta strand ( 26%)

Rank Aligned region

PDB 1dj0 chain A Region: 2 - 244 Aligned: 228 Modelled: 229 Confidence: 100.0% Identity: 35% Fold: Pseudouridine synthase Superfamily: Pseudouridine synthase Family: Pseudouridine synthase I TruA Phyre2 PDB 1vs3 chain B Region: 2 - 240 Aligned: 222 Modelled: 225 Confidence: 100.0% Identity: 35% PDB header:isomerase Chain: B: PDB Molecule:trna pseudouridine synthase a; PDBTitle: crystal structure of the trna pseudouridine synthase trua from thermus2 thermophilus hb8 Phyre2 PDB 4j37 chain A Region: 4 - 251 Aligned: 226 Modelled: 231 Confidence: 100.0% Identity: 24% PDB header:rna binding protein Chain: A: PDB Molecule:trna pseudouridine synthase a, mitochondrial; PDBTitle: crystal structure of the catalytic domain of human pus1 Phyre2 PDB 2v9k chain A Region: 1 - 183 Aligned: 154 Modelled: 167 Confidence: 91.7% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein flj32312; PDBTitle: crystal structure of human pus10, a novel pseudouridine2 synthase. Phyre2 PDB 1qys chain A Region: 6 - 32 Aligned: 27 Modelled: 27 Confidence: 50.6% Identity: 22% PDB header:de novo protein Chain: A: PDB Molecule:top7; PDBTitle: crystal structure of top7: a computationally designed2 protein with a novel fold Phyre2 PDB 2hh8 chain A domain 1 Region: 101 - 152 Aligned: 52 Modelled: 52 Confidence: 49.9% Identity: 23% Fold: YdfO-like Superfamily: YdfO-like Family: YdfO-like Phyre2 PDB 2jvf chain A Region: 6 - 32 Aligned: 27 Modelled: 27 Confidence: 45.4% Identity: 19% PDB header:de novo protein Chain: A: PDB Molecule:de novo protein m7; PDBTitle: solution structure of m7, a computationally-designed2 artificial protein Phyre2 PDB 6aef chain B Region: 121 - 146 Aligned: 26 Modelled: 26 Confidence: 28.2% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:polyketide synthase associated protein papa2; PDBTitle: papa2 acyl transferase Phyre2 PDB 1q9j chain A domain 1 Region: 121 - 146 Aligned: 26 Modelled: 26 Confidence: 26.3% Identity: 23% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: NRPS condensation domain (amide synthase) Phyre2 PDB 1l5a chain A domain 1 Region: 121 - 146 Aligned: 26 Modelled: 26 Confidence: 21.5% Identity: 15% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: NRPS condensation domain (amide synthase) Phyre2 PDB 6gny chain A Region: 3 - 31 Aligned: 28 Modelled: 29 Confidence: 18.4% Identity: 11% PDB header:structural protein Chain: A: PDB Molecule:membrane-anchored junction protein; PDBTitle: crystal structure of the majin-terb2 heterotetrameric complex Phyre2 PDB 1e88 chain A domain 3 Region: 26 - 35 Aligned: 10 Modelled: 10 Confidence: 17.8% Identity: 40% Fold: FnI-like domain Superfamily: FnI-like domain Family: Fibronectin type I module Phyre2 PDB 2xhg chain A Region: 113 - 146 Aligned: 34 Modelled: 34 Confidence: 17.3% Identity: 12% PDB header:isomerase Chain: A: PDB Molecule:tyrocidine synthetase a; PDBTitle: crystal structure of the epimerization domain from the initiation2 module of tyrocidine biosynthesis Phyre2 PDB 6ad3 chain A Region: 113 - 146 Aligned: 34 Modelled: 34 Confidence: 16.9% Identity: 12% PDB header:biosynthetic protein Chain: A: PDB Molecule:lovastatin nonaketide synthase moka; PDBTitle: structural characterization of the condensation domain from monacolin2 k polyketide synthase moka Phyre2 PDB 1l5a chain A Region: 121 - 146 Aligned: 26 Modelled: 26 Confidence: 16.3% Identity: 15% PDB header:biosynthetic protein Chain: A: PDB Molecule:amide synthase; PDBTitle: crystal structure of vibh, an nrps condensation enzyme Phyre2 PDB 6d0t chain A Region: 134 - 183 Aligned: 46 Modelled: 50 Confidence: 14.6% Identity: 20% PDB header:de novo protein Chain: A: PDB Molecule:bb1; PDBTitle: de novo design of a fluorescence-activating beta barrel - bb1 Phyre2 PDB 4tx3 chain B Region: 121 - 146 Aligned: 26 Modelled: 26 Confidence: 11.6% Identity: 31% PDB header:oxidoreductase Chain: B: PDB Molecule:peptide synthetase, module 7; PDBTitle: complex of the x-domain and oxyb from teicoplanin biosynthesis Phyre2 PDB 5t3e chain A Region: 121 - 146 Aligned: 26 Modelled: 26 Confidence: 11.5% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:bacillamide synthetase heterocyclization domain; PDBTitle: crystal structure of a nonribosomal peptide synthetase2 heterocyclization domain. Phyre2 PDB 5m6p chain B Region: 113 - 146 Aligned: 34 Modelled: 34 Confidence: 11.3% Identity: 12% PDB header:isomerase Chain: B: PDB Molecule:tyrocidine synthase 2; PDBTitle: crystal structure of the epimerization domain from module 3 of2 tyrocidine synthetase b, tycb3(e) Phyre2 PDB 3pst chain A Region: 100 - 146 Aligned: 41 Modelled: 47 Confidence: 11.1% Identity: 12% PDB header:nuclear protein Chain: A: PDB Molecule:protein doa1; PDBTitle: crystal structure of pul and pfu(mutate) domain Phyre2 1 d1dj0a_ 2 c1vs3B_ 3 c4j37A_ 4 c2v9kA_ 5 c1qysA_ 6 d2hh8a1 7 c2jvfA_ 8 c6aefB_ 9 d1q9ja1 10 d1l5aa1 11 c6gnyA_ 12 d1e88a3 13 c2xhgA_ 14 c6ad3A_ 15 c1l5aA_ 16 c6d0tA_ 17 c4tx3B_ 18 c5t3eA_ 19 c5m6pB_ 20 c3pstA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50