1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	G	L	L	P	V	A	G	H	W	V	S	V	L	T	G	L	V	P	L	A	L	V	I	A	L	S	P	L	S	V	I	P	A	V	L	V	V	H	S	P	Q	P	R	P	S	S	L	A	F	L	G	G	W	L	L	G	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	V	T	A	V	F	V	A	A	S	G	A	L	G	G	L	S	T	T	S	P	A	W	A	S	W	L	R	V	V	L	G	S	A	L	I	V	F	G	V	L	R	W	L	T	R	H	R	H	T	E	M	P	G	W	M	R	A	F	A
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?			?																					?	?	?	?	?	?	?	?	?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	F	T	P	A	R	A	G	L	V	G	A	V	L	V	V	V	R	P	E	V	L	I	I	C	A	A	A	G	L	A	I	G	S	G	G	H	G	A	A	G	S	W	I	Y	T	A	F	F	A	M	L	A	A	S	T	V	A	I	P
Secondary structure
SS confidence
Disorder		?	?	?	?											?		?																?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.
Sequence		I	L	A	Y	V	A	A	G	D	R	L	D	D	S	L	E	R	L	K	D	W	M	E	K	N	H	A	G	M	V	A	A	I	L	V	V	I	G	L	L	L	L	Y	N	G	V	H	A	M
Secondary structure
SS confidence
Disorder																																													?		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 55%) (View membrane topology prediction)

Rank Aligned region

PDB 5vkv chain A Region: 22 - 229 Aligned: 190 Modelled: 208 Confidence: 99.2% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccda; PDBTitle: solution nmr structure of the membrane electron transporter ccda Phyre2 PDB 2n4x chain A Region: 22 - 226 Aligned: 179 Modelled: 205 Confidence: 97.8% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c-type biogenesis protein (ccda); PDBTitle: structure of the transmembrane electron transporter ccda Phyre2 PDB 4zdt chain B Region: 195 - 206 Aligned: 12 Modelled: 12 Confidence: 23.6% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:structure-specific endonuclease subunit slx4; PDBTitle: crystal structure of the ring finger domain of slx1 in complex with2 the c-terminal domain of slx4 Phyre2 PDB 4ni3 chain B Region: 188 - 209 Aligned: 22 Modelled: 22 Confidence: 14.7% Identity: 9% PDB header:hydrolase Chain: B: PDB Molecule:alpha-fucosidase gh29; PDBTitle: crystal structure of gh29 family alpha-l-fucosidase from fusarium2 graminearum in the closed form Phyre2 PDB 5mb9 chain C Region: 1 - 13 Aligned: 13 Modelled: 13 Confidence: 12.8% Identity: 46% PDB header:chaperone Chain: C: PDB Molecule:putative ribosome associated protein; PDBTitle: crystal structure of the eukaryotic ribosome associated complex (rac),2 a unique hsp70/hsp40 pair Phyre2 PDB 2knc chain A Region: 71 - 113 Aligned: 43 Modelled: 43 Confidence: 12.7% Identity: 28% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1p58 chain E Region: 187 - 216 Aligned: 30 Modelled: 30 Confidence: 12.0% Identity: 10% PDB header:virus Chain: E: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 5mb9 chain D Region: 1 - 13 Aligned: 13 Modelled: 13 Confidence: 10.7% Identity: 46% PDB header:chaperone Chain: D: PDB Molecule:putative ribosome associated protein; PDBTitle: crystal structure of the eukaryotic ribosome associated complex (rac),2 a unique hsp70/hsp40 pair Phyre2 PDB 1p58 chain F Region: 187 - 214 Aligned: 28 Modelled: 28 Confidence: 10.2% Identity: 11% PDB header:virus Chain: F: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 2lkl chain A Region: 195 - 208 Aligned: 14 Modelled: 14 Confidence: 9.1% Identity: 21% PDB header:cell adhesion Chain: A: PDB Molecule:erythrocyte membrane protein 1 (pfemp1); PDBTitle: structure of the core intracellular domain of pfemp1 Phyre2 PDB 6gn6 chain A Region: 188 - 209 Aligned: 22 Modelled: 22 Confidence: 8.5% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:alpha-l-fucosidase; PDBTitle: alpha-l-fucosidase isoenzyme 1 from paenibacillus thiaminolyticus Phyre2 PDB 3bjr chain A Region: 188 - 206 Aligned: 19 Modelled: 19 Confidence: 8.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative carboxylesterase; PDBTitle: crystal structure of a putative carboxylesterase (lp_1002) from2 lactobacillus plantarum wcfs1 at 2.09 a resolution Phyre2 PDB 2g5d chain A domain 1 Region: 195 - 213 Aligned: 19 Modelled: 19 Confidence: 7.0% Identity: 16% Fold: Double psi beta-barrel Superfamily: Barwin-like endoglucanases Family: MLTA-like Phyre2 PDB 4b03 chain D Region: 187 - 216 Aligned: 30 Modelled: 30 Confidence: 6.9% Identity: 10% PDB header:virus Chain: D: PDB Molecule:dengue virus 1 prm protein; PDBTitle: 6a electron cryomicroscopy structure of immature dengue virus serotype2 1 Phyre2 PDB 2pnw chain A domain 1 Region: 195 - 213 Aligned: 19 Modelled: 19 Confidence: 6.5% Identity: 5% Fold: Double psi beta-barrel Superfamily: Barwin-like endoglucanases Family: MLTA-like Phyre2 PDB 2auw chain A domain 1 Region: 196 - 206 Aligned: 11 Modelled: 9 Confidence: 6.5% Identity: 36% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: NE0471 C-terminal domain-like Phyre2 PDB 4eq7 chain B Region: 189 - 207 Aligned: 19 Modelled: 19 Confidence: 5.6% Identity: 32% PDB header:transport protein Chain: B: PDB Molecule:abc transporter, substrate binding protein (polyamine); PDBTitle: structure of atu4243-gaba receptor Phyre2 PDB 6mjp chain F Region: 23 - 118 Aligned: 94 Modelled: 96 Confidence: 5.4% Identity: 10% PDB header:lipid transport Chain: F: PDB Molecule:fig000988: predicted permease; PDBTitle: lptb(e163q)fgc from vibrio cholerae Phyre2 PDB 2mqk chain A Region: 188 - 206 Aligned: 19 Modelled: 19 Confidence: 5.4% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent target dna activator b; PDBTitle: solution structure of n terminal domain of the mub aaa+ atpase Phyre2 PDB 3j2p chain D Region: 187 - 216 Aligned: 30 Modelled: 30 Confidence: 5.3% Identity: 10% PDB header:viral protein Chain: D: PDB Molecule:small envelope protein m; PDBTitle: cryoem structure of dengue virus envelope protein heterotetramer Phyre2 1 c5vkvA_ 2 c2n4xA_ 3 c4zdtB_ 4 c4ni3B_ 5 c5mb9C_ 6 c2kncA_ 7 c1p58E_ 8 c5mb9D_ 9 c1p58F_ 10 c2lklA_ 11 c6gn6A_ 12 c3bjrA_ 13 d2g5da1 14 c4b03D_ 15 d2pnwa1 16 d2auwa1 17 c4eq7B_ 18 c6mjpF_ 19 c2mqkA_ 20 c3j2pD_ 21 22