1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	R	S	E	G	N	R	P	R	H	R	A	V	P	Q	P	S	R	I	R	K	R	L	S	R	G	V	M	T	L	V	S	V	V	A	L	L	M	T	G	A	G	Y	W	V	A	H	G	A	L	G	G	I	T	I	S	Q	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																															?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	P	E	D	P	R	S	S	G	N	N	M	N	I	L	L	I	G	L	D	S	R	K	D	Q	E	G	N	D	L	P	W	S	V	L	K	Q	L	H	A	G	D	S	D	D	G	G	Y	N	T	N	T	L	I	L	V	H	V	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?													?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	G	K	V	V	A	F	S	I	P	R	D	D	W	V	P	F	T	G	V	P	G	Y	N	H	I	K	I	K	E	A	Y	G	L	T	K	Q	Y	V	A	E	Q	L	A	N	Q	G	V	S	D	R	K	E	L	E	T	R	G	R	E
Secondary structure
SS confidence
Disorder																					?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	R	A	A	T	L	R	A	V	R	S	L	T	G	V	P	I	D	Y	F	A	E	I	N	L	A	G	F	Y	D	L	A	Q	T	L	G	G	V	D	V	C	L	N	H	A	V	Y	D	S	Y	S	G	A	D	F	P	A	G	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	R	L	N	A	A	Q	A	L	A	F	V	R	Q	R	H	G	L	D	N	G	D	L	D	R	T	H	R	Q	Q	A	F	L	S	S	V	M	R	E	L	Q	D	S	G	T	F	T	N	L	D	R	L	D	N	L	M	A	V	A	R
Secondary structure
SS confidence
Disorder																					?	?	?																			?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	D	V	V	L	S	A	G	W	D	E	D	L	F	R	R	M	G	D	L	A	G	G	N	V	E	F	R	T	L	P	V	V	R	Y	D	N	I	D	G	Q	D	V	N	I	I	D	P	T	A	I	R	A	E	V	A	A	A	F	G
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?	?												?		?	?										?	?	?	?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	A	P	P	T	S	Q	T	A	A	A	A	K	P	N	P	S	T	V	V	D	V	V	N	A	G	S	I	S	G	L	A	S	Q	V	S	G	A	L	L	K	R	G	Y	T	A	G	Q	V	R	D	R	E	S	G	D	P	F	T	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?																			?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	I	E	Y	G	A	G	A	E	T	D	A	Q	N	V	A	D	L	L	G	I	D	A	P	N	H	P	D	P	A	V	A	P	G	H	I	R	V	T	V	D	T	N	F	S	L	P	A	P	D	E	A	T	A	A	A	T	S	T	E
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.
Sequence		T	S	T	Y	P	L	Y	G	G	G	T	T	T	D	P	T	P	D	Q	G	A	P	I	D	G	G	G	V	P	C	V	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?		?	?	?		?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 39%) Alpha helix ( 29%) Beta strand ( 15%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 3okz chain B Region: 61 - 388 Aligned: 277 Modelled: 286 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative uncharacterized protein gbs0355; PDBTitle: crystal structure of protein gbs0355 from streptococcus agalactiae,2 northeast structural genomics consortium target sar127 Phyre2 PDB 4de8 chain A Region: 62 - 358 Aligned: 249 Modelled: 251 Confidence: 100.0% Identity: 24% PDB header:membrane protein Chain: A: PDB Molecule:cps2a; PDBTitle: lytr-cps2a-psr family protein with bound octaprenyl monophosphate2 lipid Phyre2 PDB 3pe5 chain B Region: 72 - 377 Aligned: 256 Modelled: 260 Confidence: 100.0% Identity: 25% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: three-dimensional structure of protein a7vv38_9clot from clostridium2 leptum dsm 753, northeast structural genomics consortium target3 qlr103 Phyre2 PDB 5v8c chain A Region: 60 - 368 Aligned: 249 Modelled: 256 Confidence: 100.0% Identity: 23% PDB header:transcription Chain: A: PDB Molecule:transcriptional regulator; PDBTitle: lytr-csp2a-psr enzyme from actinomyces oris Phyre2 PDB 3qfi chain A Region: 67 - 367 Aligned: 234 Modelled: 248 Confidence: 100.0% Identity: 23% PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator; PDBTitle: x-ray crystal structure of transcriptional regulator (ef0465) from2 enterococcus faecalis, northeast structural genomics consortium3 target efr190 Phyre2 PDB 3owq chain B Region: 69 - 363 Aligned: 226 Modelled: 243 Confidence: 100.0% Identity: 29% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:lin1025 protein; PDBTitle: x-ray structure of lin1025 protein from listeria innocua, northeast2 structural genomics consortium target lkr164 Phyre2 PDB 3nro chain A Region: 67 - 358 Aligned: 221 Modelled: 235 Confidence: 100.0% Identity: 29% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:lmo1026 protein; PDBTitle: crystal structure of putative transcriptional factor lmo1026 from2 listeria monocytogenes (fragment 52-321), northeast structural3 genomics consortium target lmr194 Phyre2 PDB 3mej chain A Region: 57 - 360 Aligned: 231 Modelled: 252 Confidence: 100.0% Identity: 25% PDB header:transcriptional regulator Chain: A: PDB Molecule:transcriptional regulator ywtf; PDBTitle: crystal structure of putative transcriptional regulator ywtf from2 bacillus subtilis, northeast structural genomics consortium target3 sr736 Phyre2 PDB 4obm chain A Region: 51 - 361 Aligned: 250 Modelled: 254 Confidence: 100.0% Identity: 16% PDB header:transcription regulator Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative transcription regulator (eubsir_01389)2 from eubacterium siraeum dsm 15702 at 2.15 a resolution Phyre2 PDB 3nxh chain A Region: 68 - 359 Aligned: 209 Modelled: 231 Confidence: 100.0% Identity: 22% PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator yvhj; PDBTitle: crystal structure of the transcriptional regulator yvhj from bacillus2 subtilis. northeast structural genomics consortium target sr735. Phyre2 PDB 2m5y chain A Region: 360 - 461 Aligned: 102 Modelled: 102 Confidence: 99.4% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:putative tuberculin related peptide; PDBTitle: solution structure of the c-terminal domain of rv0431 Phyre2 PDB 5j5v chain C Region: 249 - 281 Aligned: 33 Modelled: 33 Confidence: 43.2% Identity: 27% PDB header:toxin Chain: C: PDB Molecule:immunity protein cdii; PDBTitle: cdia-ct from uropathogenic escherichia coli in complex with cognate2 immunity protein and cysk Phyre2 PDB 4ddp chain A Region: 145 - 212 Aligned: 40 Modelled: 40 Confidence: 36.2% Identity: 25% PDB header:membrane protein Chain: A: PDB Molecule:beclin-1; PDBTitle: crystal structure of beclin 1 evolutionarily conserved domain(ecd) Phyre2 PDB 2pju chain D Region: 187 - 282 Aligned: 88 Modelled: 96 Confidence: 31.4% Identity: 16% PDB header:transcription Chain: D: PDB Molecule:propionate catabolism operon regulatory protein; PDBTitle: crystal structure of propionate catabolism operon regulatory protein2 prpr Phyre2 PDB 3vp7 chain A Region: 145 - 212 Aligned: 40 Modelled: 40 Confidence: 25.2% Identity: 20% PDB header:protein transport Chain: A: PDB Molecule:vacuolar protein sorting-associated protein 30; PDBTitle: crystal structure of the beta-alpha repeated, autophagy-specific2 (bara) domain of vps30/atg6 Phyre2 PDB 6dfd chain B Region: 195 - 252 Aligned: 42 Modelled: 57 Confidence: 20.1% Identity: 33% PDB header:metal transport Chain: B: PDB Molecule:metal transporter cnnm3; PDBTitle: crystal structure of cnnm3 cyclic nucleotide-binding homology domain Phyre2 PDB 5z5b chain A Region: 243 - 286 Aligned: 40 Modelled: 44 Confidence: 18.5% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:protein-tyrosine phosphatase; PDBTitle: crystal structure of tk-ptp in the g95a mutant form Phyre2 PDB 1ny8 chain A Region: 262 - 282 Aligned: 21 Modelled: 21 Confidence: 15.0% Identity: 24% Fold: Alpha-lytic protease prodomain-like Superfamily: BolA-like Family: BolA-like Phyre2 PDB 2fgy chain A Region: 69 - 124 Aligned: 28 Modelled: 28 Confidence: 14.7% Identity: 57% PDB header:lyase Chain: A: PDB Molecule:carboxysome shell polypeptide; PDBTitle: beta carbonic anhydrase from the carboxysomal shell of2 halothiobacillus neapolitanus (csosca) Phyre2 PDB 6f0k chain A Region: 17 - 45 Aligned: 29 Modelled: 29 Confidence: 14.2% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c family protein; PDBTitle: alternative complex iii Phyre2 1 c3okzB_ 2 c4de8A_ 3 c3pe5B_ 4 c5v8cA_ 5 c3qfiA_ 6 c3owqB_ 7 c3nroA_ 8 c3mejA_ 9 c4obmA_ 10 c3nxhA_ 11 c2m5yA_ 12 c5j5vC_ 13 c4ddpA_ 14 c2pjuD_ 15 c3vp7A_ 16 c6dfdB_ 17 c5z5bA_ 18 d1ny8a_ 19 c2fgyA_ 20 c6f0kA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42