1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	R	I	W	L	R	A	I	I	L	T	A	S	S	A	L	L	A	G	C	Q	F	G	G	L	N	S	L	P	L	P	G	T	A	G	H	G	E	G	A	Y	S	V	T	V	E	M	A	D	V	A	T	L	P	Q	N	S	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?																												?	?	?	?	?	?	?	?													?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	V	D	D	V	T	V	G	S	V	A	G	I	V	A	V	Q	R	P	D	G	S	F	Y	A	A	V	K	L	D	L	D	K	N	V	L	L	P	A	N	A	V	A	K	V	S	Q	T	S	L	L	G	S	L	H	V	E	L	A	P
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?											?				?											?	?	?	?	?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	T	D	R	P	P	T	G	R	L	V	D	G	S	R	I	T	E	A	N	T	D	R	F	P	T	T	E	E	V	F	S	A	L	G	V	V	V	N	K	G	N	V	G	A	L	E	E	I	I	D	E	T	H	Q	A	V	A	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?														?		?																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	A	Q	F	V	N	L	V	P	R	L	A	E	L	T	A	G	L	N	R	Q	V	H	D	I	I	D	A	L	D	G	L	N	R	V	S	A	I	L	A	R	D	K	D	N	L	G	R	A	L	D	T	L	P	D	A	V	R	V	L
Secondary structure
SS confidence
Disorder																						?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	Q	N	R	D	H	I	V	D	A	F	A	A	L	K	R	L	T	M	V	T	S	H	V	L	A	E	T	K	V	D	F	G	E	D	L	K	D	L	Y	S	I	V	K	A	L	N	D	D	R	K	D	F	V	T	S	L	Q	L	L
Secondary structure
SS confidence
Disorder				?																								?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	T	F	P	F	P	N	F	G	I	K	Q	A	V	R	G	D	Y	L	N	V	F	T	T	F	D	L	T	L	R	R	I	G	E	T	F	F	T	T	A	Y	F	D	P	N	M	A	H	M	D	E	I	L	N	P	P	D	F	L	I
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?																				?	?	?	?	?		?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.
Sequence		G	E	L	A	N	L	S	G	Q	A	A	D	P	F	K	I	P	P	G	T	A	S	G	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?		?		?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 48%) Beta strand ( 15%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 10 - 152 Aligned: 133 Modelled: 143 Confidence: 99.9% Identity: 23% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 39 - 142 Aligned: 99 Modelled: 104 Confidence: 99.8% Identity: 22% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain E Region: 37 - 162 Aligned: 111 Modelled: 126 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain C Region: 37 - 162 Aligned: 111 Modelled: 126 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 37 - 162 Aligned: 111 Modelled: 126 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain F Region: 37 - 162 Aligned: 111 Modelled: 126 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain B Region: 37 - 162 Aligned: 111 Modelled: 126 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain D Region: 37 - 162 Aligned: 111 Modelled: 126 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 1qu7 chain A Region: 147 - 300 Aligned: 150 Modelled: 154 Confidence: 91.5% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 2qf4 chain A Region: 34 - 136 Aligned: 93 Modelled: 103 Confidence: 88.1% Identity: 14% PDB header:structural protein Chain: A: PDB Molecule:cell shape determining protein mrec; PDBTitle: high resolution structure of the major periplasmic domain from the2 cell shape-determining filament mrec (orthorhombic form) Phyre2 PDB 2wpq chain A Region: 184 - 283 Aligned: 99 Modelled: 100 Confidence: 86.4% Identity: 6% PDB header:membrane protein Chain: A: PDB Molecule:trimeric autotransporter adhesin fragment; PDBTitle: salmonella enterica sada 479-519 fused to gcn4 adaptors (sadak3, in-2 register fusion) Phyre2 PDB 1eq1 chain A Region: 181 - 292 Aligned: 112 Modelled: 112 Confidence: 85.4% Identity: 15% Fold: Apolipophorin-III Superfamily: Apolipophorin-III Family: Apolipophorin-III Phyre2 PDB 3zx6 chain A Region: 175 - 300 Aligned: 122 Modelled: 126 Confidence: 85.3% Identity: 11% PDB header:signaling Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i; PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant Phyre2 PDB 3lnr chain A Region: 164 - 298 Aligned: 135 Modelled: 135 Confidence: 84.6% Identity: 11% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 2ch7 chain A Region: 163 - 300 Aligned: 137 Modelled: 138 Confidence: 83.7% Identity: 9% PDB header:chemotaxis Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima Phyre2 PDB 5u0p chain U Region: 177 - 287 Aligned: 110 Modelled: 111 Confidence: 81.3% Identity: 9% PDB header:transcription Chain: U: PDB Molecule:mediator complex subunit 21; PDBTitle: cryo-em structure of the transcriptional mediator Phyre2 PDB 6gaj chain A Region: 172 - 300 Aligned: 128 Modelled: 129 Confidence: 77.5% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:outer capsid protein sigma-1; PDBTitle: crystal structure of the t1l reovirus sigma1 coiled coil tail (iodide) Phyre2 PDB 6b7n chain C Region: 177 - 290 Aligned: 114 Modelled: 114 Confidence: 76.4% Identity: 12% PDB header:viral protein Chain: C: PDB Molecule:spike protein; PDBTitle: cryo-electron microscopy structure of porcine delta coronavirus spike2 protein in the pre-fusion state Phyre2 PDB 5zuv chain B Region: 223 - 300 Aligned: 78 Modelled: 78 Confidence: 71.4% Identity: 12% PDB header:viral protein, inhibitor Chain: B: PDB Molecule:spike glycoprotein,spike glycoprotein,inhibitor ek1; PDBTitle: crystal structure of the human coronavirus 229e hr1 motif in complex2 with pan-covs inhibitor ek1 Phyre2 PDB 1ykh chain B domain 1 Region: 174 - 279 Aligned: 105 Modelled: 106 Confidence: 69.9% Identity: 8% Fold: Mediator hinge subcomplex-like Superfamily: Mediator hinge subcomplex-like Family: CSE2-like Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnE_ 4 c5uvnC_ 5 c5uvnA_ 6 c5uvnF_ 7 c5uvnB_ 8 c5uvnD_ 9 c1qu7A_ 10 c2qf4A_ 11 c2wpqA_ 12 d1eq1a_ 13 c3zx6A_ 14 c3lnrA_ 15 c2ch7A_ 16 c5u0pU_ 17 c6gajA_ 18 c6b7nC_ 19 c5zuvB_ 20 d1ykhb1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99