1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	S	L	S	E	N	L	S	C	H	S	S	N	M	C	R	L	S	G	N	A	A	T	N	L	E	R	P	G	E	E	P	P	G	D	R	C	T	R	R	Q	A	V	R	P	A	R	T	L	A	K	K	G	N	I	P	V	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?					?	?	?		?		?	?	?																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	Y	K	D	E	K	K	T	A	E	T	F	R	T	I	N	G	V	R	Y	A	I	P	G	D	Y	A	Q	V	E	E	D	G	T	V	T	M	L	G	R	G	S	V	S	I	N	S	G	G	E	K	V	Y	P	E	E	V	E	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	K	G	H	P	D	V	F	D	A	L	V	V	G	V	P	D	P	R	Y	G	Q	Q	V	A	A	V	V	Q	A	R	P	G	C	R	P	S	L	A	E	L	D	S	F	V	R	S	E	I	A	G	Y	K	V	P	R	S	L	W	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.
Sequence		V	D	E	V	K	R	S	P	A	G	K	P	D	Y	R	W	A	K	E	Q	T	E	A	R	P	A	D	D	V	H	A	G	H	V	T	S	G	S
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 24%) Beta strand ( 25%)

Rank Aligned region

PDB 6eqo chain B Region: 1 - 206 Aligned: 206 Modelled: 206 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:acetyl-coenzyme a synthetase; PDBTitle: tri-functional propionyl-coa synthase of erythrobacter sp. nap1 with2 bound nadp+ and phosphomethylphosphonic acid adenylate ester Phyre2 PDB 6p1j chain A Region: 2 - 197 Aligned: 196 Modelled: 196 Confidence: 100.0% Identity: 20% PDB header:biosynthetic protein Chain: A: PDB Molecule:txo2; PDBTitle: the structure of condensation and adenylation domains of teixobactin-2 producing nonribosomal peptide synthetase txo2 serine module Phyre2 PDB 5es8 chain A Region: 2 - 208 Aligned: 205 Modelled: 207 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:linear gramicidin synthetase subunit a; PDBTitle: crystal structure of the initiation module of lgra in the thiolation2 state Phyre2 PDB 6n8e chain A Region: 2 - 208 Aligned: 202 Modelled: 207 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:holo-obif1; PDBTitle: crystal structure of holo-obif1, a five domain nonribosomal peptide2 synthetase from burkholderia diffusa Phyre2 PDB 4zxi chain A Region: 1 - 211 Aligned: 208 Modelled: 211 Confidence: 100.0% Identity: 20% PDB header:biosynthetic protein Chain: A: PDB Molecule:tyrocidine synthetase 3; PDBTitle: crystal structure of holo-ab3403 a four domain nonribosomal peptide2 synthetase bound to amp and glycine Phyre2 PDB 4eat chain B Region: 2 - 203 Aligned: 198 Modelled: 202 Confidence: 100.0% Identity: 27% PDB header:ligase Chain: B: PDB Molecule:benzoate-coenzyme a ligase; PDBTitle: crystal structure of a benzoate coenzyme a ligase Phyre2 PDB 5ifi chain A Region: 2 - 209 Aligned: 207 Modelled: 208 Confidence: 100.0% Identity: 24% PDB header:ligase Chain: A: PDB Molecule:acetyl-coenzyme a synthetase; PDBTitle: crystal structure of acetyl-coa synthetase in complex with adenosine-2 5'-propylphosphate from cryptococcus neoformans h99 Phyre2 PDB 5ja2 chain A Region: 2 - 211 Aligned: 210 Modelled: 210 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:enterobactin synthase component f; PDBTitle: entf, a terminal nonribosomal peptide synthetase module bound to the2 non-native mbth-like protein pa2412 Phyre2 PDB 4oxi chain A Region: 2 - 200 Aligned: 198 Modelled: 198 Confidence: 100.0% Identity: 16% PDB header:ligase Chain: A: PDB Molecule:enterobactin synthetase component f-related protein; PDBTitle: crystal structure of vibrio cholerae adenylation domain alme in2 complex with glycyl-adenosine-5'-phosphate Phyre2 PDB 5gxd chain A Region: 2 - 211 Aligned: 209 Modelled: 210 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:amp-dependent synthetase and ligase; PDBTitle: structure of acryloyl-coa lyase prpe from dinoroseobacter shibae dfl2 12 Phyre2 PDB 2vsq chain A Region: 2 - 214 Aligned: 211 Modelled: 213 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a nonribosomal peptide2 synthetase termination module Phyre2 PDB 5ie2 chain A Region: 2 - 201 Aligned: 196 Modelled: 200 Confidence: 100.0% Identity: 24% PDB header:ligase Chain: A: PDB Molecule:oxalate--coa ligase; PDBTitle: crystal structure of a plant enzyme Phyre2 PDB 3e7w chain A Region: 2 - 204 Aligned: 202 Modelled: 203 Confidence: 100.0% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: crystal structure of dlta: implications for the reaction mechanism of2 non-ribosomal peptide synthetase (nrps) adenylation domains Phyre2 PDB 4zxj chain A Region: 2 - 197 Aligned: 196 Modelled: 196 Confidence: 100.0% Identity: 19% PDB header:biosynthetic protein Chain: A: PDB Molecule:enterobactin synthase component f; PDBTitle: crystal structure of holo-entf a nonribosomal peptide synthetase in2 the thioester-forming conformation Phyre2 PDB 6h1b chain A Region: 1 - 201 Aligned: 197 Modelled: 201 Confidence: 100.0% Identity: 29% PDB header:ligase Chain: A: PDB Molecule:fatty acid coa ligase; PDBTitle: structure of amide bond synthetase mcba k483a mutant from2 marinactinospora thermotolerans Phyre2 PDB 5u2a chain A Region: 2 - 204 Aligned: 200 Modelled: 203 Confidence: 100.0% Identity: 27% PDB header:ligase Chain: A: PDB Molecule:amp-dependent synthetase and ligase; PDBTitle: crystal structure of brucella canis acyl-coa synthetase Phyre2 PDB 3r44 chain A Region: 1 - 206 Aligned: 201 Modelled: 206 Confidence: 100.0% Identity: 24% PDB header:ligase Chain: A: PDB Molecule:fatty acyl coa synthetase fadd13 (fatty-acyl-coa PDBTitle: mycobacterium tuberculosis fatty acyl coa synthetase Phyre2 PDB 5apl chain A Region: 1 - 204 Aligned: 202 Modelled: 204 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:adenylation domain; PDBTitle: structure of the adenylation domain thr1 involved in the biosynthesis2 of 4-chlorothreonine in streptomyces sp. oh-5093, apo structure Phyre2 PDB 5msd chain A Region: 1 - 215 Aligned: 210 Modelled: 211 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:carboxylic acid reductase; PDBTitle: structure of the a domain of carboxylic acid reductase (car) from2 nocardia iowensis in complex with amp and benzoic acid Phyre2 PDB 5u89 chain A Region: 2 - 209 Aligned: 198 Modelled: 208 Confidence: 100.0% Identity: 24% PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:amino acid adenylation domain protein; PDBTitle: crystal structure of a cross-module fragment from the dimodular nrps2 dhbf Phyre2 1 c6eqoB_ 2 c6p1jA_ 3 c5es8A_ 4 c6n8eA_ 5 c4zxiA_ 6 c4eatB_ 7 c5ifiA_ 8 c5ja2A_ 9 c4oxiA_ 10 c5gxdA_ 11 c2vsqA_ 12 c5ie2A_ 13 c3e7wA_ 14 c4zxjA_ 15 c6h1bA_ 16 c5u2aA_ 17 c3r44A_ 18 c5aplA_ 19 c5msdA_ 20 c5u89A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99