1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	E	P	F	L	G	S	E	A	I	A	S	G	A	L	T	R	H	R	L	R	S	A	Y	A	T	I	H	P	D	V	Y	V	S	P	G	A	D	L	T	A	W	S	R	A	Q	A	A	W	L	W	S	R	R	R	G	V	I	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	Q	S	A	A	A	M	H	G	A	K	W	V	D	A	R	Q	A	A	E	L	L	Y	D	H	R	R	P	P	A	G	I	H	T	W	S	D	R	V	A	D	D	E	I	Q	P	I	S	G	M	N	T	T	T	P	A	R	T	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	L	A	R	R	Y	P	V	G	K	A	V	A	A	I	D	A	L	A	R	A	T	D	L	K	L	A	D	V	E	M	L	A	E	R	Y	R	G	S	R	G	I	R	N	A	R	I	A	L	D	L	V	D	P	G	A	E	S	P	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	T	W	L	R	L	L	L	I	R	A	G	F	P	R	P	Q	T	Q	I	P	V	Y	D	E	Y	G	Q	L	V	A	V	I	D	M	G	W	A	G	I	K	V	G	V	D	Y	E	G	D	H	H	R	T	D	R	R	T	F	N	K
Secondary structure
SS confidence
Disorder																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.
Sequence		D	I	K	R	A	E	A	L	T	E	L	G	W	T	D	V	R	V	T	V	E	D	T	E	G	G	I	I	W	R	V	S	A	A	W	Q	R	R	T
Secondary structure
SS confidence
Disorder																																						?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 4%) Alpha helix ( 44%) Beta strand ( 20%)

Rank Aligned region

PDB 3r3p chain B Region: 177 - 277 Aligned: 93 Modelled: 101 Confidence: 99.7% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:mobile intron protein; PDBTitle: homing endonuclease i-bth0305i catalytic domain Phyre2 PDB 3hrl chain A Region: 176 - 278 Aligned: 89 Modelled: 103 Confidence: 99.4% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae Phyre2 PDB 1cw0 chain A Region: 175 - 279 Aligned: 98 Modelled: 105 Confidence: 99.3% Identity: 18% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1vsr chain A Region: 181 - 279 Aligned: 92 Modelled: 99 Confidence: 98.1% Identity: 18% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 4oq2 chain A Region: 195 - 278 Aligned: 84 Modelled: 84 Confidence: 96.5% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease pvurts1 i; PDBTitle: 5hmc specific restriction endonuclease pvurts1i Phyre2 PDB 4par chain C Region: 195 - 278 Aligned: 82 Modelled: 84 Confidence: 96.1% Identity: 22% PDB header:dna binding protein/dna Chain: C: PDB Molecule:uncharacterized protein abasi; PDBTitle: the 5-hydroxymethylcytosine-specific restriction enzyme abasi in a2 complex with product-like dna Phyre2 PDB 6rdu chain 2 Region: 204 - 277 Aligned: 74 Modelled: 74 Confidence: 95.7% Identity: 12% PDB header:proton transport Chain: 2: PDB Molecule:asa-2: polytomella f-atp synthase associated subunit 2; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1e,2 monomer-masked refinement Phyre2 PDB 1zel chain A Region: 7 - 177 Aligned: 162 Modelled: 171 Confidence: 81.7% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein rv2827c; PDBTitle: crystal structure of rv2827c protein from mycobacterium tuberculosis Phyre2 PDB 1zel chain A domain 2 Region: 55 - 177 Aligned: 117 Modelled: 123 Confidence: 74.9% Identity: 19% Fold: Rv2827c C-terminal domain-like Superfamily: Rv2827c C-terminal domain-like Family: Rv2827c C-terminal domain-like Phyre2 PDB 1m0d chain A Region: 178 - 250 Aligned: 65 Modelled: 73 Confidence: 59.9% Identity: 17% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 PDB 2fcl chain A domain 1 Region: 56 - 81 Aligned: 26 Modelled: 26 Confidence: 25.0% Identity: 15% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: TM1012-like Phyre2 PDB 4ytk chain A Region: 23 - 33 Aligned: 11 Modelled: 11 Confidence: 11.6% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt5; PDBTitle: structure of the kow1-linker1 domain of transcription elongation2 factor spt5 Phyre2 PDB 2fuk chain A domain 1 Region: 192 - 258 Aligned: 67 Modelled: 67 Confidence: 11.2% Identity: 21% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Atu1826-like Phyre2 PDB 1tfe chain A Region: 219 - 277 Aligned: 59 Modelled: 59 Confidence: 10.7% Identity: 10% Fold: EF-Ts domain-like Superfamily: Elongation factor Ts (EF-Ts), dimerisation domain Family: Elongation factor Ts (EF-Ts), dimerisation domain Phyre2 PDB 2hw2 chain A Region: 220 - 256 Aligned: 36 Modelled: 37 Confidence: 10.6% Identity: 8% PDB header:transferase Chain: A: PDB Molecule:rifampin adp-ribosyl transferase; PDBTitle: crystal structure of rifampin adp-ribosyl transferase in complex with2 rifampin Phyre2 PDB 4gqz chain B Region: 193 - 229 Aligned: 37 Modelled: 36 Confidence: 9.5% Identity: 22% PDB header:metal binding protein Chain: B: PDB Molecule:putative periplasmic or exported protein; PDBTitle: crystal structure of s.cuep Phyre2 PDB 1jg5 chain A Region: 246 - 259 Aligned: 14 Modelled: 14 Confidence: 9.0% Identity: 21% Fold: GTP cyclohydrolase I feedback regulatory protein, GFRP Superfamily: GTP cyclohydrolase I feedback regulatory protein, GFRP Family: GTP cyclohydrolase I feedback regulatory protein, GFRP Phyre2 PDB 2iea chain A domain 2 Region: 245 - 270 Aligned: 26 Modelled: 26 Confidence: 7.0% Identity: 12% Fold: Thiamin diphosphate-binding fold (THDP-binding) Superfamily: Thiamin diphosphate-binding fold (THDP-binding) Family: TK-like PP module Phyre2 PDB 1ccw chain A Region: 245 - 273 Aligned: 29 Modelled: 29 Confidence: 6.9% Identity: 21% Fold: Flavodoxin-like Superfamily: Cobalamin (vitamin B12)-binding domain Family: Cobalamin (vitamin B12)-binding domain Phyre2 PDB 5vrv chain A Region: 214 - 277 Aligned: 63 Modelled: 64 Confidence: 6.4% Identity: 13% PDB header:hydrolase,oxidoreductase Chain: A: PDB Molecule:protein regulated by acid ph; PDBTitle: 2.05 angstrom resolution crystal structure of c-terminal domain2 (duf2156) of putative lysylphosphatidylglycerol synthetase from3 agrobacterium fabrum. Phyre2 1 c3r3pB_ 2 c3hrlA_ 3 d1cw0a_ 4 d1vsra_ 5 c4oq2A_ 6 c4parC_ 7 c6rdu2_ 8 c1zelA_ 9 d1zela2 10 d1m0da_ 11 d2fcla1 12 c4ytkA_ 13 d2fuka1 14 d1tfea_ 15 c2hw2A_ 16 c4gqzB_ 17 d1jg5a_ 18 d2ieaa2 19 d1ccwa_ 20 c5vrvA_ 21 22 23 24