1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	V	S	Q	H	T	I	A	G	T	V	L	T	M	P	V	R	I	R	T	A	N	L	H	S	A	M	F	S	V	P	A	D	P	A	Q	R	L	I	D	Y	S	G	L	R	V	C	E	Y	L	P	G	K	A	I	V	M	Q	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																				?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	R	Y	V	D	G	D	L	G	R	Y	H	E	Y	G	T	A	I	M	V	N	P	P	G	T	Q	R	R	G	P	R	A	L	T	R	A	A	A	F	I	H	H	L	P	V	D	Q	V	F	T	L	E	A	G	R	T	I	W	G
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	P	K	I	M	A	D	F	N	V	T	D	G	R	R	F	G	F	D	V	S	A	D	G	R	L	I	A	G	I	E	F	S	T	G	L	P	V	P	T	L	G	W	Q	M	L	K	T	Y	S	H	H	D	G	V	T	R	E	I	P
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?	?	?	?	?		?	?	?					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.
Sequence		W	E	M	K	V	S	G	L	R	A	R	L	G	G	A	R	L	R	L	G	D	H	P	Y	A	K	E	L	A	S	L	G	L	P	K	R	A	L	L	S	Q	S	A	A	N	V	E	M	T	F	G	D	G	H	P	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?		?		?	?	?	?	?	?	?	?													?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 11%) Beta strand ( 47%)

Rank Aligned region

PDB 3bh2 chain C Region: 3 - 236 Aligned: 215 Modelled: 234 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: C: PDB Molecule:acetoacetate decarboxylase; PDBTitle: structural studies of acetoacetate decarboxylase Phyre2 PDB 3bgt chain D Region: 3 - 236 Aligned: 216 Modelled: 232 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: D: PDB Molecule:probable acetoacetate decarboxylase; PDBTitle: structural studies of acetoacetate decarboxylase Phyre2 PDB 3c8w chain A domain 1 Region: 14 - 236 Aligned: 204 Modelled: 222 Confidence: 100.0% Identity: 21% Fold: Acetoacetate decarboxylase-like Superfamily: Acetoacetate decarboxylase-like Family: Acetoacetate decarboxylase-like Phyre2 PDB 4jme chain A Region: 12 - 236 Aligned: 202 Modelled: 225 Confidence: 100.0% Identity: 19% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein mppr; PDBTitle: enduracididine biosynthesis enzyme mppr complexed with 2-keto-2 enduracididine Phyre2 PDB 5upb chain A Region: 11 - 236 Aligned: 201 Modelled: 221 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:acetoacetate decarboxylase; PDBTitle: swit_4259, an acetoacetate decarboxylase-like enzyme from sphingomonas2 wittichii rw1 Phyre2 PDB 4zbt chain B Region: 1 - 232 Aligned: 216 Modelled: 232 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:acetoacetate decarboxylase; PDBTitle: streptomyces bingchenggensis aldolase-dehydratase in schiff base2 complex with pyruvate Phyre2 PDB 3cmb chain A domain 1 Region: 14 - 234 Aligned: 209 Modelled: 218 Confidence: 99.9% Identity: 16% Fold: Acetoacetate decarboxylase-like Superfamily: Acetoacetate decarboxylase-like Family: Acetoacetate decarboxylase-like Phyre2 PDB 1tg7 chain A domain 1 Region: 117 - 153 Aligned: 36 Modelled: 37 Confidence: 40.5% Identity: 17% Fold: Beta-galactosidase LacA, domain 3 Superfamily: Beta-galactosidase LacA, domain 3 Family: Beta-galactosidase LacA, domain 3 Phyre2 PDB 5tey chain B Region: 101 - 130 Aligned: 29 Modelled: 30 Confidence: 17.7% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:n6-adenosine-methyltransferase subunit mettl14; PDBTitle: human mettl3-mettl14 complex Phyre2 PDB 2jsp chain A Region: 116 - 123 Aligned: 8 Modelled: 8 Confidence: 6.5% Identity: 38% PDB header:gene regulation Chain: A: PDB Molecule:transcriptional regulatory protein ros; PDBTitle: the prokaryotic cys2his2 zinc finger adopts a novel fold as2 revealed by the nmr structure of a. tumefaciens ros dna3 binding domain Phyre2 PDB 6nu9 chain A Region: 200 - 233 Aligned: 32 Modelled: 34 Confidence: 6.2% Identity: 19% PDB header:viral protein Chain: A: PDB Molecule:zinc-binding non-structural protein; PDBTitle: crystal structure of a zinc-binding non-structural protein from the2 hepatitis e virus Phyre2 PDB 1cf4 chain B Region: 115 - 127 Aligned: 13 Modelled: 13 Confidence: 5.5% Identity: 38% PDB header:transferase Chain: B: PDB Molecule:protein (activated p21cdc42hs kinase); PDBTitle: cdc42/ack gtpase-binding domain complex Phyre2 PDB 5mhj chain A Region: 110 - 122 Aligned: 13 Modelled: 13 Confidence: 5.5% Identity: 38% PDB header:transcription Chain: A: PDB Molecule:major viral transcription factor icp4; PDBTitle: icp4 dna-binding domain, lacking intrinsically disordered region, in2 complex with 12mer dna duplex from its own promoter Phyre2 1 c3bh2C_ 2 c3bgtD_ 3 d3c8wa1 4 c4jmeA_ 5 c5upbA_ 6 c4zbtB_ 7 d3cmba1 8 d1tg7a1 9 c5teyB_ 10 c2jspA_ 11 c6nu9A_ 12 c1cf4B_ 13 c5mhjA_