1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	T	D	T	S	G	V	G	V	R	E	I	D	A	G	A	L	P	T	R	Y	A	R	G	W	H	C	L	G	V	A	K	D	Y	L	E	G	K	P	H	G	V	E	A	F	G	T	K	L	V	V	F	A	D	S	H	G	D	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	V	L	D	G	Y	C	R	H	M	G	G	D	L	S	E	G	T	V	K	G	D	E	V	A	C	P	F	H	D	W	R	W	G	G	D	G	R	C	K	L	V	P	Y	A	R	R	T	P	R	M	A	R	T	R	S	W	T	T	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	R	S	G	L	L	F	V	W	H	D	H	E	G	N	P	P	D	P	A	V	R	I	P	E	I	P	E	A	A	S	D	E	W	T	D	W	R	W	N	R	I	L	I	E	G	S	N	C	R	D	I	I	D	N	V	T	D	M	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	F	F	Y	I	H	F	G	L	P	T	Y	F	K	N	V	F	E	G	H	I	A	S	Q	Y	L	H	N	V	G	R	P	D	V	D	D	L	G	T	S	Y	G	E	A	H	L	D	S	E	A	S	Y	F	G	P	S	F	M	I	N
Secondary structure
SS confidence
Disorder																	?															?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	L	H	N	R	Y	G	N	Y	K	S	E	S	I	L	I	N	C	H	Y	P	V	T	Q	N	S	F	V	L	Q	W	G	V	I	V	E	K	P	K	G	M	S	E	E	M	T	D	K	L	S	R	V	F	T	E	G	V	S	K	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	L	Q	D	V	E	I	W	K	H	K	T	R	I	D	N	P	L	L	V	E	E	D	G	A	V	Y	Q	L	R	R	W	Y	E	Q	F	Y	V	D	V	A	D	I	K	P	E	M	V	E	R	F	E	I	E	V	D	T	K	R	A
Secondary structure
SS confidence
Disorder											?	?				?	?																									?	?	?	?	?	?	?	?	?		?	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.
Sequence		N	E	F	W	N	A	E	V	E	K	N	L	K	S	R	E	V	S	D	D	V	P	A	E	Q	H
Secondary structure
SS confidence
Disorder						?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 19%) Beta strand ( 29%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 2zyl chain A Region: 14 - 374 Aligned: 359 Modelled: 361 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: A: PDB Molecule:possible oxidoreductase; PDBTitle: crystal structure of 3-ketosteroid-9-alpha-hydroxylase2 (ksha) from m. tuberculosis Phyre2 PDB 4qdf chain A Region: 19 - 376 Aligned: 358 Modelled: 358 Confidence: 100.0% Identity: 62% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:3-ketosteroid 9alpha-hydroxylase oxygenase; PDBTitle: crystal structure of apo ksha5 and ksha1 in complex with 1,4-30q-coa2 from r. rhodochrous Phyre2 PDB 4qdf chain B Region: 19 - 383 Aligned: 357 Modelled: 365 Confidence: 100.0% Identity: 61% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: B: PDB Molecule:3-ketosteroid 9alpha-hydroxylase oxygenase; PDBTitle: crystal structure of apo ksha5 and ksha1 in complex with 1,4-30q-coa2 from r. rhodochrous Phyre2 PDB 3gte chain B Region: 20 - 336 Aligned: 308 Modelled: 317 Confidence: 100.0% Identity: 17% PDB header:electron transport, oxidoreductase Chain: B: PDB Molecule:ddmc; PDBTitle: crystal structure of dicamba monooxygenase with non-heme iron Phyre2 PDB 3gkq chain B Region: 17 - 346 Aligned: 319 Modelled: 330 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole 1,9a-dioxygenase; PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from novosphingobium2 sp. ka1 Phyre2 PDB 3vca chain A Region: 17 - 337 Aligned: 309 Modelled: 318 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:ring-hydroxylating dioxygenase; PDBTitle: quaternary ammonium oxidative demethylation: x-ray crystallographic,2 resonance raman and uv-visible spectroscopic analysis of a rieske-3 type demethylase Phyre2 PDB 2de7 chain B Region: 16 - 337 Aligned: 310 Modelled: 322 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole; PDBTitle: the substrate-bound complex between oxygenase and2 ferredoxin in carbazole 1,9a-dioxygenase Phyre2 PDB 3n0q chain A Region: 17 - 341 Aligned: 313 Modelled: 314 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:putative aromatic-ring hydroxylating dioxygenase; PDBTitle: crystal structure of a putative aromatic-ring hydroxylating2 dioxygenase (tm1040_3219) from silicibacter sp. tm1040 at 1.80 a3 resolution Phyre2 PDB 3gcf chain C Region: 22 - 337 Aligned: 305 Modelled: 311 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:terminal oxygenase component of carbazole 1,9a- PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from2 nocardioides aromaticivorans ic177 Phyre2 PDB 1z01 chain D Region: 22 - 336 Aligned: 311 Modelled: 315 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: D: PDB Molecule:2-oxo-1,2-dihydroquinoline 8-monooxygenase, oxygenase PDBTitle: 2-oxoquinoline 8-monooxygenase component: active site modulation by2 rieske-[2fe-2s] center oxidation/reduction Phyre2 PDB 1ulj chain A Region: 12 - 336 Aligned: 309 Modelled: 325 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:biphenyl dioxygenase large subunit; PDBTitle: biphenyl dioxygenase (bpha1a2) in complex with the substrate Phyre2 PDB 1wql chain A Region: 12 - 349 Aligned: 319 Modelled: 332 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:iron-sulfur protein large subunit of cumene dioxygenase; PDBTitle: cumene dioxygenase (cuma1a2) from pseudomonas fluorescens ip01 Phyre2 PDB 2b1x chain E Region: 11 - 343 Aligned: 327 Modelled: 333 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: E: PDB Molecule:naphthalene dioxygenase large subunit; PDBTitle: crystal structure of naphthalene 1,2-dioxygenase from rhodococcus sp. Phyre2 PDB 2hmn chain A Region: 12 - 370 Aligned: 337 Modelled: 347 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:naphthalene 1,2-dioxygenase alpha subunit; PDBTitle: crystal structure of the naphthalene 1,2-dioxygenase f352v2 mutant bound to anthracene. Phyre2 PDB 2gbx chain E Region: 12 - 363 Aligned: 299 Modelled: 299 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: E: PDB Molecule:biphenyl 2,3-dioxygenase alpha subunit; PDBTitle: crystal structure of biphenyl 2,3-dioxygenase from sphingomonas2 yanoikuyae b1 bound to biphenyl Phyre2 PDB 1wql chain A domain 1 Region: 17 - 133 Aligned: 117 Modelled: 117 Confidence: 100.0% Identity: 23% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 1uli chain A domain 1 Region: 11 - 133 Aligned: 123 Modelled: 123 Confidence: 100.0% Identity: 18% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 1z01 chain A domain 1 Region: 17 - 144 Aligned: 124 Modelled: 128 Confidence: 100.0% Identity: 17% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2b1x chain A domain 1 Region: 17 - 133 Aligned: 117 Modelled: 117 Confidence: 100.0% Identity: 19% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2de6 chain A domain 1 Region: 3 - 135 Aligned: 132 Modelled: 133 Confidence: 100.0% Identity: 18% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 1 c2zylA_ 2 c4qdfA_ 3 c4qdfB_ 4 c3gteB_ 5 c3gkqB_ 6 c3vcaA_ 7 c2de7B_ 8 c3n0qA_ 9 c3gcfC_ 10 c1z01D_ 11 c1uljA_ 12 c1wqlA_ 13 c2b1xE_ 14 c2hmnA_ 15 c2gbxE_ 16 d1wqla1 17 d1ulia1 18 d1z01a1 19 d2b1xa1 20 d2de6a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99