1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	L	D	R	L	R	Q	G	G	Y	W	L	V	R	G	K	I	N	L	I	D	R	A	F	T	S	C	R	I	E	S	F	A	D	L	G	A	V	W	G	V	E	G	A	Y	T	F	R	A	L	D	K	Y	P	V	K	E	A	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	D	G	R	I	T	P	T	V	A	A	R	A	N	S	Y	P	Q	L	R	V	I	E	G	N	F	G	D	Q	E	I	A	D	K	V	G	N	V	D	A	L	F	L	F	D	V	L	L	H	Q	V	S	P	D	W	D	T	I	L
Secondary structure
SS confidence
Disorder													?	?	?	?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	M	Y	A	K	N	V	R	C	L	L	I	Y	N	Q	Q	W	I	G	S	T	T	T	V	R	L	L	D	L	G	E	K	H	Y	F	R	N	V	P	H	S	K	L	N	K	A	Y	R	D	L	F	Q	K	L	D	K	K	H	P	D
Secondary structure
SS confidence
Disorder																																						?																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.
Sequence		H	D	K	P	W	R	D	I	P	D	I	W	Q	W	G	I	T	D	A	D	L	E	S	K	A	S	E	L	G	F	K	L	L	Y	K	E	D	C	R	G	F	G	W	L	P	N	I	Q	N	R	A	F	L	F	A	R	Q
Secondary structure
SS confidence
Disorder		?	?	?																									?										?		?	?												?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 43%) Beta strand ( 22%)

Rank Aligned region

PDB 3tka chain A Region: 44 - 104 Aligned: 61 Modelled: 61 Confidence: 39.5% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:ribosomal rna small subunit methyltransferase h; PDBTitle: crystal structure and solution saxs of methyltransferase rsmh from2 e.coli Phyre2 PDB 4er3 chain A Region: 33 - 104 Aligned: 69 Modelled: 72 Confidence: 29.3% Identity: 20% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:histone-lysine n-methyltransferase, h3 lysine-79 specific; PDBTitle: crystal structure of human dot1l in complex with inhibitor epz004777 Phyre2 PDB 1nw3 chain A Region: 33 - 104 Aligned: 69 Modelled: 72 Confidence: 28.7% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:histone methyltransferase dot1l; PDBTitle: structure of the catalytic domain of human dot1l, a non-set domain2 nucleosomal histone methyltransferase Phyre2 PDB 1nw3 chain A Region: 33 - 104 Aligned: 69 Modelled: 72 Confidence: 28.7% Identity: 20% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Catalytic, N-terminal domain of histone methyltransferase Dot1l Phyre2 PDB 2bg5 chain C Region: 93 - 166 Aligned: 65 Modelled: 74 Confidence: 28.6% Identity: 25% PDB header:transferase Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase; PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme i-domain2 from the thermoanaerobacter tengcongensis pep: sugar3 phosphotransferase system (pts) Phyre2 PDB 3u21 chain B Region: 134 - 149 Aligned: 16 Modelled: 16 Confidence: 28.3% Identity: 38% PDB header:transcription regulation, dna binding Chain: B: PDB Molecule:nuclear factor related to kappa-b-binding protein; PDBTitle: crystal structure of a fragment of nuclear factor related to kappa-b-2 binding protein (residues 370-495) (nfrkb) from homo sapiens at 2.183 a resolution Phyre2 PDB 1fpq chain A Region: 29 - 135 Aligned: 96 Modelled: 107 Confidence: 27.1% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:isoliquiritigenin 2'-o-methyltransferase; PDBTitle: crystal structure analysis of selenomethionine substituted chalcone o-2 methyltransferase Phyre2 PDB 1m6y chain A Region: 44 - 104 Aligned: 59 Modelled: 60 Confidence: 25.1% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:s-adenosyl-methyltransferase mraw; PDBTitle: crystal structure analysis of tm0872, a putative sam-dependent2 methyltransferase, complexed with sah Phyre2 PDB 1fp1 chain D domain 2 Region: 43 - 128 Aligned: 78 Modelled: 86 Confidence: 24.0% Identity: 21% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Plant O-methyltransferase, C-terminal domain Phyre2 PDB 4qdk chain B Region: 44 - 216 Aligned: 135 Modelled: 147 Confidence: 22.7% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:magnesium-protoporphyrin o-methyltransferase; PDBTitle: crystal structure of magnesium protoporphyrin ix methyltransferase2 (chlm) from synechocystis pcc 6803 with bound sah Phyre2 PDB 4p7c chain B Region: 43 - 173 Aligned: 124 Modelled: 130 Confidence: 22.6% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:trna (mo5u34)-methyltransferase; PDBTitle: crystal structure of putative methyltransferase from pseudomonas2 syringae pv. tomato Phyre2 PDB 1fp2 chain A Region: 20 - 135 Aligned: 105 Modelled: 116 Confidence: 22.6% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:isoflavone o-methyltransferase; PDBTitle: crystal structure analysis of isoflavone o-methyltransferase Phyre2 PDB 6ecv chain B Region: 44 - 211 Aligned: 143 Modelled: 149 Confidence: 20.4% Identity: 10% PDB header:transferase Chain: B: PDB Molecule:stid protein; PDBTitle: stid o-mt residues 976-1266 Phyre2 PDB 2fpw chain A domain 1 Region: 55 - 96 Aligned: 42 Modelled: 42 Confidence: 20.2% Identity: 14% Fold: HAD-like Superfamily: HAD-like Family: Histidinol phosphatase-like Phyre2 PDB 3lw6 chain A Region: 191 - 230 Aligned: 40 Modelled: 40 Confidence: 19.3% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:beta-4-galactosyltransferase 7; PDBTitle: crystal structure of drosophila beta1,4-galactosyltransferase-7 Phyre2 PDB 4a6d chain A Region: 29 - 212 Aligned: 144 Modelled: 163 Confidence: 18.6% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:hydroxyindole o-methyltransferase; PDBTitle: crystal structure of human n-acetylserotonin2 methyltransferase (asmt) in complex with sam Phyre2 PDB 6i5z chain A Region: 43 - 212 Aligned: 133 Modelled: 151 Confidence: 18.5% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:o-methyltransferase 1; PDBTitle: papaver somniferum o-methyltransferase Phyre2 PDB 6gkv chain B Region: 17 - 128 Aligned: 104 Modelled: 112 Confidence: 18.2% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:coclaurine n-methyltransferase; PDBTitle: crystal structure of coclaurine n-methyltransferase (cnmt) bound to n-2 methylheliamine and sah Phyre2 PDB 3uds chain A Region: 119 - 152 Aligned: 32 Modelled: 34 Confidence: 17.9% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:inositol-pentakisphosphate 2-kinase; PDBTitle: inositol 1,3,4,5,6-pentakisphosphate 2-kinase from a. thaliana in2 complex with adp. Phyre2 PDB 3f1i chain H Region: 165 - 180 Aligned: 16 Modelled: 16 Confidence: 17.6% Identity: 38% PDB header:protein binding Chain: H: PDB Molecule:hepatocyte growth factor-regulated tyrosine kinase PDBTitle: human escrt-0 core complex Phyre2 1 c3tkaA_ 2 c4er3A_ 3 c1nw3A_ 4 d1nw3a_ 5 c2bg5C_ 6 c3u21B_ 7 c1fpqA_ 8 c1m6yA_ 9 d1fp1d2 10 c4qdkB_ 11 c4p7cB_ 12 c1fp2A_ 13 c6ecvB_ 14 d2fpwa1 15 c3lw6A_ 16 c4a6dA_ 17 c6i5zA_ 18 c6gkvB_ 19 c3udsA_ 20 c3f1iH_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99