1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	R	P	D	R	K	D	V	A	T	V	D	E	L	H	A	S	A	T	K	L	V	G	L	D	D	F	G	T	D	D	D	N	Y	R	E	A	L	G	V	L	L	D	A	Y	Q	G	E	A	G	L	T	V	L	G	S	K	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	R	F	F	L	R	G	A	L	V	A	R	L	L	S	Q	S	A	W	K	Q	Y	P	E	H	V	D	V	A	I	K	R	P	I	F	V	T	G	L	V	R	T	G	T	T	A	L	H	R	L	L	G	A	D	P	A	H	Q	G	L
Secondary structure
SS confidence
Disorder																	?	?									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	M	W	L	A	E	Y	P	Q	P	R	P	P	R	E	T	W	E	S	N	P	L	Y	R	Q	L	D	A	Q	F	T	Q	H	H	A	E	N	P	G	Y	T	G	L	H	F	M	A	A	Y	E	L	E	E	C	W	Q	L	L	R	Q
Secondary structure
SS confidence
Disorder															?		?																			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	L	H	S	V	S	Y	E	A	L	A	H	V	P	S	Y	A	D	W	L	S	R	Q	D	W	T	P	S	Y	C	R	H	R	R	N	L	Q	L	I	G	L	N	D	A	E	K	R	W	V	L	K	N	P	S	H	L	F	A	L	D
Secondary structure
SS confidence
Disorder					?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	L	M	A	T	Y	P	D	A	L	V	V	Q	T	H	R	P	V	E	T	I	M	A	S	M	C	S	L	A	Q	H	T	T	E	G	W	S	T	K	F	V	G	A	Q	I	G	A	D	A	M	D	T	W	S	R	G	L	E	R	F
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	A	A	R	A	K	Y	D	S	A	Q	F	Y	D	V	D	Y	H	D	L	I	A	D	P	L	G	T	V	A	D	I	Y	R	H	F	G	L	T	L	S	D	E	A	R	Q	A	M	T	T	V	H	A	E	S	Q	S	G	A	R	A
Secondary structure
SS confidence
Disorder																																																					?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.
Sequence		P	K	H	S	Y	S	L	A	D	Y	G	L	T	V	E	M	V	K	E	R	F	A	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?																	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 57%) Beta strand ( 6%)

Rank Aligned region

PDB 2zq5 chain A Region: 7 - 384 Aligned: 365 Modelled: 365 Confidence: 100.0% Identity: 99% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of sulfotransferase stf1 from2 mycobacterium tuberculosis h37rv (type1 form) Phyre2 PDB 2z6v chain A Region: 5 - 382 Aligned: 374 Modelled: 378 Confidence: 100.0% Identity: 27% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of sulfotransferase stf9 from2 mycobacterium avium Phyre2 PDB 4gbm chain A Region: 89 - 344 Aligned: 216 Modelled: 220 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:curm sulfotransferase; PDBTitle: sulfotransferase domain from the curacin biosynthetic pathway Phyre2 PDB 3ap3 chain A Region: 92 - 345 Aligned: 188 Modelled: 194 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:protein-tyrosine sulfotransferase 2; PDBTitle: crystal structure of human tyrosylprotein sulfotransferase-2 complexed2 with pap Phyre2 PDB 4gox chain A Region: 91 - 344 Aligned: 205 Modelled: 217 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:polyketide synthase; PDBTitle: sulfotransferase domain from the synechococcus pcc 7002 olefin2 synthase Phyre2 PDB 1tex chain A Region: 91 - 340 Aligned: 220 Modelled: 227 Confidence: 99.9% Identity: 15% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 3rnl chain A Region: 90 - 354 Aligned: 206 Modelled: 206 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase; PDBTitle: crystal structure of sulfotransferase from alicyclobacillus2 acidocaldarius Phyre2 PDB 1vkj chain A Region: 92 - 341 Aligned: 175 Modelled: 175 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:heparan sulfate (glucosamine) 3-o-sulfotransferase 1; PDBTitle: crystal structure of heparan sulfate 3-o-sulfotransferase isoform 1 in2 the presence of pap Phyre2 PDB 1vkj chain A Region: 92 - 341 Aligned: 175 Modelled: 175 Confidence: 99.9% Identity: 15% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1t8t chain A Region: 94 - 353 Aligned: 183 Modelled: 183 Confidence: 99.9% Identity: 22% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1nst chain A Region: 93 - 340 Aligned: 175 Modelled: 175 Confidence: 99.9% Identity: 18% PDB header:sulfotransferase Chain: A: PDB Molecule:heparan sulfate n-deacetylase/n-sulfotransferase; PDBTitle: the sulfotransferase domain of human haparin sulfate n-deacetylase/n-2 sulfotransferase Phyre2 PDB 1nst chain A Region: 93 - 340 Aligned: 175 Modelled: 175 Confidence: 99.9% Identity: 18% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 3bd9 chain A Region: 93 - 340 Aligned: 173 Modelled: 173 Confidence: 99.9% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:heparan sulfate glucosamine 3-o-sulfotransferase PDBTitle: human 3-o-sulfotransferase isoform 5 with bound pap Phyre2 PDB 1ls6 chain A Region: 88 - 349 Aligned: 188 Modelled: 192 Confidence: 99.9% Identity: 15% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2gwh chain A Region: 88 - 349 Aligned: 189 Modelled: 192 Confidence: 99.9% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1c2; PDBTitle: human sulfotranferase sult1c2 in complex with pap and2 pentachlorophenol Phyre2 PDB 3u3o chain A Region: 88 - 349 Aligned: 188 Modelled: 192 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1a1; PDBTitle: crystal structure of human sult1a1 bound to pap and two 3-cyano-7-2 hydroxycoumarin Phyre2 PDB 1fmj chain A Region: 88 - 352 Aligned: 221 Modelled: 224 Confidence: 99.9% Identity: 18% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1xv1 chain A Region: 88 - 349 Aligned: 189 Modelled: 193 Confidence: 99.9% Identity: 11% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1j99 chain A Region: 91 - 349 Aligned: 180 Modelled: 182 Confidence: 99.9% Identity: 13% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2a3r chain A domain 1 Region: 88 - 349 Aligned: 189 Modelled: 192 Confidence: 99.9% Identity: 14% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 1 c2zq5A_ 2 c2z6vA_ 3 c4gbmA_ 4 c3ap3A_ 5 c4goxA_ 6 d1texa_ 7 c3rnlA_ 8 c1vkjA_ 9 d1vkja_ 10 d1t8ta_ 11 c1nstA_ 12 d1nsta_ 13 c3bd9A_ 14 d1ls6a_ 15 c2gwhA_ 16 c3u3oA_ 17 d1fmja_ 18 d1xv1a_ 19 d1j99a_ 20 d2a3ra1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234