1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	R	D	A	T	R	D	E	L	A	A	D	L	A	Q	A	E	R	S	R	D	P	I	G	Q	L	T	A	A	H	P	E	I	D	V	V	D	A	Y	E	I	Q	L	I	N	I	R	Q	R	V	A	E	G	A	R	V	V	G	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	V	G	L	S	S	P	I	M	Q	Q	M	M	G	V	D	E	P	D	Y	G	H	L	L	D	D	M	Q	V	F	E	D	T	P	V	Q	A	S	R	Y	L	S	P	R	V	E	V	E	V	G	F	I	L	A	A	D	L	P	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	C	T	E	D	D	V	L	A	A	T	E	A	L	V	P	A	I	E	L	I	D	T	R	I	K	D	W	Q	I	K	I	C	D	T	I	A	D	N	A	S	A	A	G	F	V	L	G	A	A	R	V	P	P	A	D	L	D	V	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	I	D	A	K	L	T	R	N	G	E	V	V	A	E	G	R	S	D	A	V	L	G	N	P	A	T	A	V	A	W	L	A	G	K	V	E	S	F	G	V	R	L	R	K	G	D	I	V	L	P	G	S	C	T	F	A	V	E	A
Secondary structure
SS confidence
Disorder																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.
Sequence		R	A	G	D	E	F	V	A	D	F	T	G	L	G	L	V	R	L	S	F	E
Secondary structure
SS confidence
Disorder																						?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 27%) Beta strand ( 25%)

Rank Aligned region

PDB 5d2h chain A Region: 2 - 260 Aligned: 259 Modelled: 259 Confidence: 100.0% Identity: 34% PDB header:lyase Chain: A: PDB Molecule:4-oxalocrotonate decarboxylase nahk; PDBTitle: 4-oxalocrotonate decarboxylase from pseudomonas putida g7 - complexed2 with magnesium and alpha-ketoglutarate Phyre2 PDB 1sv6 chain A Region: 2 - 260 Aligned: 259 Modelled: 259 Confidence: 100.0% Identity: 42% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 2eb5 chain D Region: 1 - 260 Aligned: 258 Modelled: 258 Confidence: 100.0% Identity: 43% PDB header:lyase Chain: D: PDB Molecule:2-oxo-hept-3-ene-1,7-dioate hydratase; PDBTitle: crystal structure of hpcg complexed with oxalate Phyre2 PDB 3l53 chain F Region: 60 - 261 Aligned: 195 Modelled: 202 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:putative fumarylacetoacetate isomerase/hydrolase; PDBTitle: crystal structure of a putative fumarylacetoacetate2 isomerase/hydrolase from oleispira antarctica Phyre2 PDB 1saw chain A Region: 60 - 261 Aligned: 187 Modelled: 202 Confidence: 100.0% Identity: 19% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 3qdf chain A Region: 56 - 260 Aligned: 186 Modelled: 205 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from mycobacterium marinum Phyre2 PDB 3s52 chain A Region: 60 - 257 Aligned: 191 Modelled: 198 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:putative fumarylacetoacetate hydrolase family protein; PDBTitle: crystal structure of a putative fumarylacetoacetate hydrolase family2 protein from yersinia pestis co92 Phyre2 PDB 4maq chain B Region: 60 - 261 Aligned: 190 Modelled: 202 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:putative fumarylpyruvate hydrolase; PDBTitle: crystal structure of a putative fumarylpyruvate hydrolase from2 burkholderia cenocepacia Phyre2 PDB 1nr9 chain A Region: 60 - 257 Aligned: 184 Modelled: 198 Confidence: 100.0% Identity: 21% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1gtt chain A domain 1 Region: 60 - 260 Aligned: 187 Modelled: 198 Confidence: 100.0% Identity: 15% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1wzo chain C Region: 60 - 260 Aligned: 185 Modelled: 201 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: C: PDB Molecule:hpce; PDBTitle: crystal structure of the hpce from thermus thermophilus hb8 Phyre2 PDB 1gtt chain A domain 2 Region: 60 - 260 Aligned: 187 Modelled: 201 Confidence: 100.0% Identity: 15% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 6iym chain B Region: 60 - 261 Aligned: 192 Modelled: 202 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; PDBTitle: fumarylacetoacetate hydrolase (eafah) from psychrophilic2 exiguobacterium antarcticum Phyre2 PDB 1i7o chain C Region: 60 - 260 Aligned: 187 Modelled: 201 Confidence: 100.0% Identity: 15% PDB header:isomerase, lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate degradation bifunctional PDBTitle: crystal structure of hpce Phyre2 PDB 2dfu chain B Region: 60 - 260 Aligned: 189 Modelled: 201 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: B: PDB Molecule:probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from thermus thermophilus hb8 Phyre2 PDB 3r6o chain A Region: 60 - 260 Aligned: 186 Modelled: 201 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1, 7-dioateisomerase; PDBTitle: crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7-2 dioateisomerase from mycobacterium abscessus Phyre2 PDB 6jvw chain A Region: 60 - 260 Aligned: 174 Modelled: 201 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:maleylpyruvate hydrolase; PDBTitle: crystal structure of maleylpyruvate hydrolase from sphingobium sp.2 syk-6 in complex with manganese (ii) ion and pyruvate Phyre2 PDB 4dbh chain A Region: 60 - 260 Aligned: 191 Modelled: 201 Confidence: 100.0% Identity: 13% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of cg1458 with inhibitor Phyre2 PDB 1nkq chain A Region: 60 - 261 Aligned: 196 Modelled: 200 Confidence: 100.0% Identity: 16% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 3lzk chain C Region: 60 - 260 Aligned: 191 Modelled: 201 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: C: PDB Molecule:fumarylacetoacetate hydrolase family protein; PDBTitle: the crystal structure of a probably aromatic amino acid2 degradation protein from sinorhizobium meliloti 1021 Phyre2 1 c5d2hA_ 2 d1sv6a_ 3 c2eb5D_ 4 c3l53F_ 5 d1sawa_ 6 c3qdfA_ 7 c3s52A_ 8 c4maqB_ 9 d1nr9a_ 10 d1gtta1 11 c1wzoC_ 12 d1gtta2 13 c6iymB_ 14 c1i7oC_ 15 c2dfuB_ 16 c3r6oA_ 17 c6jvwA_ 18 c4dbhA_ 19 d1nkqa_ 20 c3lzkC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99