1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	I	D	L	D	V	A	L	G	A	Q	L	P	P	V	E	F	S	W	T	S	T	D	V	Q	L	Y	Q	L	G	L	G	A	G	S	D	P	M	N	P	R	E	L	S	Y	L	A	D	D	T	P	Q	V	L	P	T	F	G	N
Secondary structure
SS confidence
Disorder		?	?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	A	T	F	H	L	T	T	P	P	T	V	Q	F	P	G	I	D	I	E	L	S	K	V	L	H	A	S	E	R	V	E	V	P	A	P	L	P	P	S	G	S	A	R	A	V	T	R	F	T	D	I	W	D	K	G	K	A	A
Secondary structure
SS confidence
Disorder			?	?		?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	I	C	S	E	T	T	A	T	T	P	D	G	L	L	L	W	T	Q	K	R	S	I	Y	A	R	G	E	G	G	F	G	G	K	R	G	P	S	G	S	D	V	A	P	E	R	A	P	D	L	Q	V	A	M	P	I	L	P	Q	Q
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	L	Y	R	L	C	G	D	R	N	P	L	H	S	D	P	E	F	A	A	A	A	G	F	P	R	P	I	L	H	G	L	C	T	Y	G	M	T	C	K	A	I	V	D	A	L	L	D	S	D	A	T	A	V	A	G	Y	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.
Sequence		R	F	A	G	V	A	Y	P	G	E	T	L	T	V	N	V	W	K	D	G	R	R	L	V	A	S	V	V	A	P	T	R	D	N	A	V	V	L	S	G	V	E	L	V	P	A
Secondary structure
SS confidence
Disorder																																														?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 23%) Beta strand ( 37%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 3oml chain A Region: 14 - 282 Aligned: 253 Modelled: 269 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:peroxisomal multifunctional enzyme type 2, cg3415; PDBTitle: structure of full-length peroxisomal multifunctional enzyme type 22 from drosophila melanogaster Phyre2 PDB 3kh8 chain B Region: 3 - 286 Aligned: 278 Modelled: 284 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: B: PDB Molecule:maoc-like dehydratase; PDBTitle: crystal structure of maoc-like dehydratase from phytophthora capsici Phyre2 PDB 3khp chain B Region: 1 - 282 Aligned: 271 Modelled: 282 Confidence: 100.0% Identity: 38% PDB header:oxidoreductase Chain: B: PDB Molecule:maoc family protein; PDBTitle: crystal structure of a possible dehydrogenase from mycobacterium2 tuberculosis at 2.3a resolution Phyre2 PDB 1s9c chain K Region: 9 - 282 Aligned: 253 Modelled: 256 Confidence: 100.0% Identity: 33% PDB header:lyase Chain: K: PDB Molecule:peroxisomal multifunctional enzyme type 2; PDBTitle: crystal structure analysis of the 2-enoyl-coa hydratase 22 domain of human peroxisomal multifunctional enzyme type 2 Phyre2 PDB 1pn2 chain D Region: 17 - 282 Aligned: 258 Modelled: 266 Confidence: 100.0% Identity: 32% PDB header:lyase Chain: D: PDB Molecule:peroxisomal hydratase-dehydrogenase-epimerase; PDBTitle: crystal structure analysis of the selenomethionine labelled2 2-enoyl-coa hydratase 2 domain of candida tropicalis3 multifunctional enzyme type 2 Phyre2 PDB 2cdh chain T Region: 8 - 282 Aligned: 245 Modelled: 259 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: T: PDB Molecule:dehydratase; PDBTitle: architecture of the thermomyces lanuginosus fungal fatty2 acid synthase at 5 angstrom resolution. Phyre2 PDB 4v12 chain A Region: 5 - 284 Aligned: 274 Modelled: 274 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc like domain protein; PDBTitle: crystal structure of the msmeg_6754 dehydratase from mycobacterium2 smegmatis Phyre2 PDB 2vkz chain H Region: 9 - 285 Aligned: 267 Modelled: 277 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: H: PDB Molecule:fatty acid synthase subunit beta; PDBTitle: structure of the cerulenin-inhibited fungal fatty acid synthase type i2 multienzyme complex Phyre2 PDB 2uva chain I Region: 9 - 285 Aligned: 268 Modelled: 277 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: I: PDB Molecule:fatty acid synthase beta subunits; PDBTitle: crystal structure of fatty acid synthase from thermomyces2 lanuginosus at 3.1 angstrom resolution. this file contains3 the beta subunits of the fatty acid synthase. the entire4 crystal structure consists of one heterododecameric fatty5 acid synthase and is described in remark 400 Phyre2 PDB 4b3y chain B Region: 13 - 285 Aligned: 263 Modelled: 248 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase; PDBTitle: cryo-em structure of the mycobacterial fatty acid synthase Phyre2 PDB 4e3e chain A Region: 9 - 284 Aligned: 267 Modelled: 268 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc domain protein dehydratase; PDBTitle: crystal structure of putative maoc domain protein dehydratase from2 chloroflexus aurantiacus j-10-fl Phyre2 PDB 1pn2 chain A domain 1 Region: 15 - 159 Aligned: 142 Modelled: 145 Confidence: 100.0% Identity: 20% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 1s9c chain A domain 1 Region: 162 - 282 Aligned: 121 Modelled: 121 Confidence: 100.0% Identity: 40% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 1pn2 chain A domain 2 Region: 159 - 286 Aligned: 123 Modelled: 128 Confidence: 100.0% Identity: 42% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 1s9c chain A domain 2 Region: 8 - 146 Aligned: 117 Modelled: 123 Confidence: 100.0% Identity: 26% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 4rlt chain A Region: 1 - 153 Aligned: 150 Modelled: 146 Confidence: 99.9% Identity: 11% PDB header:lyase/lyase inhibitor Chain: A: PDB Molecule:(3r)-hydroxyacyl-acp dehydratase subunit hada; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium tuberculosis complexed with fisetin Phyre2 PDB 2bi0 chain A Region: 9 - 257 Aligned: 235 Modelled: 236 Confidence: 99.9% Identity: 14% PDB header:hypothetical protein Chain: A: PDB Molecule:hypothetical protein rv0216; PDBTitle: rv0216, a conserved hypothetical protein from mycobacterium2 tuberculosis that is essential for bacterial survival3 during infection, has a double hotdogfold Phyre2 PDB 4rv2 chain A Region: 8 - 144 Aligned: 132 Modelled: 137 Confidence: 99.9% Identity: 11% PDB header:lyase Chain: A: PDB Molecule:upf0336 protein msmeg_1340/msmei_1302; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium smegmatis Phyre2 PDB 4w7b chain D Region: 176 - 283 Aligned: 106 Modelled: 108 Confidence: 99.8% Identity: 19% PDB header:lyase Chain: D: PDB Molecule:hydratase chsh2; PDBTitle: crystal structure of the chsh1:chsh2: complex from mycobacterium2 tuberculosis Phyre2 PDB 5zy8 chain A Region: 3 - 144 Aligned: 131 Modelled: 142 Confidence: 99.8% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:upf0336 protein rv0637; PDBTitle: crystal structure of c terminal truncated hadbc (3r-hydroxyacyl-acp2 dehydratase) complex from mycobacterium tuberculosis Phyre2 1 c3omlA_ 2 c3kh8B_ 3 c3khpB_ 4 c1s9cK_ 5 c1pn2D_ 6 c2cdhT_ 7 c4v12A_ 8 c2vkzH_ 9 c2uvaI_ 10 c4b3yB_ 11 c4e3eA_ 12 d1pn2a1 13 d1s9ca1 14 d1pn2a2 15 d1s9ca2 16 c4rltA_ 17 c2bi0A_ 18 c4rv2A_ 19 c4w7bD_ 20 c5zy8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158