1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	G	V	S	D	I	Q	E	A	V	A	Q	I	K	A	A	G	P	S	K	P	R	L	A	R	D	P	V	N	Q	P	M	I	N	N	W	V	E	A	I	G	D	R	N	P	I	Y	V	D	D	A	A	A	R	A	A	G	H	P
Secondary structure
SS confidence
Disorder		?	?	?											?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	I	V	A	P	P	A	M	I	Q	V	W	T	M	M	G	L	G	G	V	R	P	K	D	D	P	L	G	P	I	I	K	L	F	D	D	A	G	Y	I	G	V	V	A	T	N	C	E	Q	T	Y	H	R	Y	L	L	P	G	E	Q
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	S	I	S	A	E	L	G	D	V	V	G	P	K	Q	T	A	L	G	E	G	W	F	I	N	Q	H	I	V	W	Q	V	G	D	E	D	V	A	E	M	N	W	R	I	L	K	F	K	P	A	G	S	P	S	S	V	P	D	D	L
Secondary structure
SS confidence
Disorder													?	?	?		?	?																														?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	P	D	A	M	M	R	P	S	S	S	R	D	T	A	F	F	W	D	G	V	K	A	H	E	L	R	I	Q	R	L	A	D	G	S	L	R	H	P	P	V	P	A	V	W	Q	D	K	S	V	P	I	N	Y	V	V	S	S	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	T	V	F	S	F	V	V	H	H	A	P	K	V	P	G	R	T	V	P	F	V	I	A	L	V	E	L	E	E	G	V	R	M	L	G	E	L	R	G	A	D	P	A	R	V	A	I	G	M	P	V	R	A	T	Y	I	D	F	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.
Sequence		D	W	S	L	Y	A	W	E	P	D	E
Secondary structure
SS confidence
Disorder									?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 16%) Beta strand ( 36%)

Rank Aligned region

PDB 4w7b chain G Region: 7 - 169 Aligned: 163 Modelled: 163 Confidence: 100.0% Identity: 100% PDB header:lyase Chain: G: PDB Molecule:hydratase chsh1; PDBTitle: crystal structure of the chsh1:chsh2: complex from mycobacterium2 tuberculosis Phyre2 PDB 6ok1 chain B Region: 186 - 309 Aligned: 124 Modelled: 124 Confidence: 100.0% Identity: 41% PDB header:transport protein Chain: B: PDB Molecule:chsh2(duf35); PDBTitle: ltp2-chsh2(duf35) aldolase Phyre2 PDB 6et9 chain H Region: 195 - 309 Aligned: 114 Modelled: 115 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: H: PDB Molecule:pfam duf35; PDBTitle: structure of the acetoacetyl-coa-thiolase/hmg-coa-synthase complex2 from methanothermococcus thermolithotrophicus at 2.75 a Phyre2 PDB 5mg5 chain W Region: 180 - 310 Aligned: 131 Modelled: 131 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: W: PDB Molecule:2,4-diacetylphloroglucinol biosynthesis protein; PDBTitle: a multi-component acyltransferase phlabc from pseudomonas protegens2 soaked with the monoacetylphloroglucinol (mapg) Phyre2 PDB 2gnr chain A domain 1 Region: 190 - 301 Aligned: 109 Modelled: 112 Confidence: 100.0% Identity: 17% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: SSO2064-like Phyre2 PDB 4v12 chain A Region: 11 - 248 Aligned: 214 Modelled: 227 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc like domain protein; PDBTitle: crystal structure of the msmeg_6754 dehydratase from mycobacterium2 smegmatis Phyre2 PDB 4rlt chain A Region: 18 - 172 Aligned: 140 Modelled: 155 Confidence: 100.0% Identity: 16% PDB header:lyase/lyase inhibitor Chain: A: PDB Molecule:(3r)-hydroxyacyl-acp dehydratase subunit hada; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium tuberculosis complexed with fisetin Phyre2 PDB 4rv2 chain A Region: 18 - 165 Aligned: 131 Modelled: 148 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:upf0336 protein msmeg_1340/msmei_1302; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium smegmatis Phyre2 PDB 5zy8 chain A Region: 18 - 165 Aligned: 126 Modelled: 136 Confidence: 99.9% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:upf0336 protein rv0637; PDBTitle: crystal structure of c terminal truncated hadbc (3r-hydroxyacyl-acp2 dehydratase) complex from mycobacterium tuberculosis Phyre2 PDB 4e3e chain A Region: 18 - 207 Aligned: 172 Modelled: 174 Confidence: 99.9% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc domain protein dehydratase; PDBTitle: crystal structure of putative maoc domain protein dehydratase from2 chloroflexus aurantiacus j-10-fl Phyre2 PDB 3exz chain A Region: 18 - 168 Aligned: 134 Modelled: 137 Confidence: 99.9% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:maoc-like dehydratase; PDBTitle: crystal structure of the maoc-like dehydratase from rhodospirillum2 rubrum. northeast structural genomics consortium target rrr103a. Phyre2 PDB 4ffu chain A Region: 18 - 169 Aligned: 134 Modelled: 136 Confidence: 99.9% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidase; PDBTitle: crystal structure of putative maoc-like (monoamine oxidase-like)2 protein, similar to nodn from sinorhizo bium meliloti 1021 Phyre2 PDB 1q6w chain A Region: 24 - 169 Aligned: 132 Modelled: 146 Confidence: 99.9% Identity: 13% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 2c2i chain A domain 1 Region: 11 - 165 Aligned: 139 Modelled: 155 Confidence: 99.9% Identity: 19% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 5cpg chain A Region: 29 - 191 Aligned: 132 Modelled: 147 Confidence: 99.9% Identity: 12% PDB header:lyase Chain: A: PDB Molecule:(r)-specific enoyl-coa hydratase; PDBTitle: r-hydratase phaj1 from pseudomonas aeruginosa in the unliganded form Phyre2 PDB 2bi0 chain A Region: 18 - 205 Aligned: 170 Modelled: 172 Confidence: 99.8% Identity: 16% PDB header:hypothetical protein Chain: A: PDB Molecule:hypothetical protein rv0216; PDBTitle: rv0216, a conserved hypothetical protein from mycobacterium2 tuberculosis that is essential for bacterial survival3 during infection, has a double hotdogfold Phyre2 PDB 1iq6 chain A Region: 29 - 165 Aligned: 115 Modelled: 121 Confidence: 99.8% Identity: 12% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 2bi0 chain A domain 1 Region: 29 - 191 Aligned: 147 Modelled: 147 Confidence: 99.8% Identity: 16% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 3khp chain B Region: 15 - 191 Aligned: 159 Modelled: 165 Confidence: 99.8% Identity: 9% PDB header:oxidoreductase Chain: B: PDB Molecule:maoc family protein; PDBTitle: crystal structure of a possible dehydrogenase from mycobacterium2 tuberculosis at 2.3a resolution Phyre2 PDB 4w7b chain D Region: 14 - 157 Aligned: 118 Modelled: 127 Confidence: 99.8% Identity: 14% PDB header:lyase Chain: D: PDB Molecule:hydratase chsh2; PDBTitle: crystal structure of the chsh1:chsh2: complex from mycobacterium2 tuberculosis Phyre2 1 c4w7bG_ 2 c6ok1B_ 3 c6et9H_ 4 c5mg5W_ 5 d2gnra1 6 c4v12A_ 7 c4rltA_ 8 c4rv2A_ 9 c5zy8A_ 10 c4e3eA_ 11 c3exzA_ 12 c4ffuA_ 13 d1q6wa_ 14 d2c2ia1 15 c5cpgA_ 16 c2bi0A_ 17 d1iq6a_ 18 d2bi0a1 19 c3khpB_ 20 c4w7bD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274