1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	E	L	P	W	P	V	L	G	S	E	V	L	A	A	K	A	I	P	E	R	A	M	R	Q	L	Y	E	P	V	Y	P	G	V	Y	A	P	A	G	V	E	L	T	A	R	Q	R	A	H	A	A	W	L	W	S	R	R	R	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	V	A	G	N	S	A	A	A	L	L	G	A	K	W	V	N	P	A	L	D	A	E	L	V	H	A	N	R	K	P	P	P	R	I	V	V	H	T	D	R	L	A	P	H	E	T	V	A	V	D	G	V	A	V	T	T	P	A	R
Secondary structure
SS confidence
Disorder																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	A	F	D	I	G	R	R	T	P	S	R	L	Q	A	V	Q	R	L	D	A	L	A	N	S	T	D	V	K	V	A	D	V	Q	A	V	I	A	E	H	T	G	A	R	G	L	V	R	L	R	A	V	L	P	L	I	D	G	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	S	P	Q	E	T	W	T	R	L	V	L	I	D	A	G	L	P	K	P	Q	T	Q	I	R	V	F	D	D	Y	G	D	F	V	A	R	I	D	L	G	Y	E	Q	L	R	V	G	V	E	Y	D	G	P	Q	H	W	T	D	P	A
Secondary structure
SS confidence
Disorder																																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.
Sequence		Q	R	A	R	D	I	E	R	S	T	A	L	L	D	L	G	W	T	I	I	R	V	T	S	E	L	L	W	Y	R	R	G	T	F	V	G	R	V	D	A	A	M	R	A	A	G	W	R	P
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 44%) Beta strand ( 20%)

Rank Aligned region

PDB 3r3p chain B Region: 181 - 284 Aligned: 95 Modelled: 104 Confidence: 99.7% Identity: 12% PDB header:hydrolase Chain: B: PDB Molecule:mobile intron protein; PDBTitle: homing endonuclease i-bth0305i catalytic domain Phyre2 PDB 3hrl chain A Region: 180 - 284 Aligned: 91 Modelled: 105 Confidence: 99.5% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae Phyre2 PDB 1cw0 chain A Region: 179 - 284 Aligned: 99 Modelled: 106 Confidence: 99.5% Identity: 18% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1vsr chain A Region: 185 - 286 Aligned: 95 Modelled: 102 Confidence: 98.4% Identity: 19% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 4oq2 chain A Region: 199 - 282 Aligned: 83 Modelled: 84 Confidence: 97.5% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease pvurts1 i; PDBTitle: 5hmc specific restriction endonuclease pvurts1i Phyre2 PDB 4par chain C Region: 199 - 284 Aligned: 84 Modelled: 86 Confidence: 96.9% Identity: 27% PDB header:dna binding protein/dna Chain: C: PDB Molecule:uncharacterized protein abasi; PDBTitle: the 5-hydroxymethylcytosine-specific restriction enzyme abasi in a2 complex with product-like dna Phyre2 PDB 6rdu chain 2 Region: 208 - 267 Aligned: 60 Modelled: 60 Confidence: 96.1% Identity: 10% PDB header:proton transport Chain: 2: PDB Molecule:asa-2: polytomella f-atp synthase associated subunit 2; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1e,2 monomer-masked refinement Phyre2 PDB 1zel chain A domain 2 Region: 58 - 230 Aligned: 158 Modelled: 173 Confidence: 87.6% Identity: 17% Fold: Rv2827c C-terminal domain-like Superfamily: Rv2827c C-terminal domain-like Family: Rv2827c C-terminal domain-like Phyre2 PDB 1zel chain A Region: 25 - 230 Aligned: 189 Modelled: 206 Confidence: 82.2% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein rv2827c; PDBTitle: crystal structure of rv2827c protein from mycobacterium tuberculosis Phyre2 PDB 1m0d chain A Region: 182 - 254 Aligned: 65 Modelled: 73 Confidence: 48.2% Identity: 15% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 PDB 4gqz chain B Region: 197 - 233 Aligned: 37 Modelled: 36 Confidence: 31.6% Identity: 24% PDB header:metal binding protein Chain: B: PDB Molecule:putative periplasmic or exported protein; PDBTitle: crystal structure of s.cuep Phyre2 PDB 2fcl chain A domain 1 Region: 59 - 84 Aligned: 26 Modelled: 26 Confidence: 27.2% Identity: 27% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: TM1012-like Phyre2 PDB 4ytk chain A Region: 26 - 36 Aligned: 11 Modelled: 11 Confidence: 9.1% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt5; PDBTitle: structure of the kow1-linker1 domain of transcription elongation2 factor spt5 Phyre2 PDB 2fuk chain A domain 1 Region: 196 - 262 Aligned: 67 Modelled: 67 Confidence: 6.6% Identity: 15% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Atu1826-like Phyre2 1 c3r3pB_ 2 c3hrlA_ 3 d1cw0a_ 4 d1vsra_ 5 c4oq2A_ 6 c4parC_ 7 c6rdu2_ 8 d1zela2 9 c1zelA_ 10 d1m0da_ 11 c4gqzB_ 12 d2fcla1 13 c4ytkA_ 14 d2fuka1