1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	I	R	S	L	G	Y	L	R	I	E	A	T	D	M	A	A	W	R	E	Y	G	L	K	V	L	G	M	V	E	G	K	G	A	P	E	G	A	L	Y	L	R	M	D	D	F	P	A	R	L	V	V	V	P	G	E	H	D	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	E	A	G	W	E	C	A	N	A	E	G	L	Q	E	I	R	N	R	L	D	L	E	G	T	P	Y	K	E	A	T	A	A	E	L	A	D	R	R	V	D	E	M	I	R	F	A	D	P	S	G	N	C	L	E	V	F	H	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	A	L	E	H	R	R	V	V	S	P	Y	G	H	R	F	V	T	G	E	Q	G	M	G	H	V	V	L	S	T	R	D	D	A	E	A	L	H	F	Y	R	D	V	L	G	F	R	L	R	D	S	M	R	L	P	P	Q	M	V	G
Secondary structure
SS confidence
Disorder					?	?	?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	P	A	D	G	P	P	A	W	L	R	F	F	G	C	N	P	R	H	H	S	L	A	F	L	P	M	P	T	S	S	G	I	V	H	L	M	V	E	V	E	Q	A	D	D	V	G	L	C	L	D	R	A	L	R	R	K	V	P	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	A	T	L	G	R	H	V	N	D	L	M	L	S	F	Y	M	K	T	P	G	G	F	D	I	E	F	G	C	E	G	R	Q	V	D	D	R	D	W	I	A	R	E	S	T	A	V	S	L	W	G	H	D	F	T	V	G	A	R	G
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 16%) Beta strand ( 36%)

Rank Aligned region

PDB 2zi8 chain A Region: 1 - 299 Aligned: 299 Modelled: 299 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: A: PDB Molecule:probable biphenyl-2,3-diol 1,2-dioxygenase bphc; PDBTitle: crystal structure of the hsac extradiol dioxygenase from m.2 tuberculosis in complex with 3,4-dihydroxy-9,10-3 seconandrost-1,3,5(10)-triene-9,17-dione (dhsa) Phyre2 PDB 1kw3 chain B Region: 2 - 293 Aligned: 283 Modelled: 292 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: B: PDB Molecule:2,3-dihydroxybiphenyl dioxygenase; PDBTitle: crystal structure of 2,3-dihydroxybiphenyal dioxygenase (bphc) at 1.452 a resolution Phyre2 PDB 2wl9 chain A Region: 1 - 300 Aligned: 289 Modelled: 300 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:catechol 2,3-dioxygenase; PDBTitle: crystal structure of catechol 2,3-dioxygenase Phyre2 PDB 2ei2 chain A Region: 2 - 300 Aligned: 288 Modelled: 299 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:1,2-dihydroxynaphthalene dioxygenase; PDBTitle: crystal structure analysis of the 1,2-dihydroxynaphthalene dioxygenase2 from pseudomonas sp. stain c18 Phyre2 PDB 3vb0 chain D Region: 2 - 295 Aligned: 281 Modelled: 294 Confidence: 100.0% Identity: 31% PDB header:oxidoreductase Chain: D: PDB Molecule:glyoxalase/bleomycin resistance protein/dioxygenase; PDBTitle: crystal structure of 2,2',3-trihydroxybiphenyl 1,2-dioxygenase from2 dibenzofuran-degrading sphingomonas wittichii strain rw1 Phyre2 PDB 3ecj chain C Region: 2 - 295 Aligned: 280 Modelled: 294 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:protein (homoprotocatechuate 2,3-dioxygenase); PDBTitle: structure of e323l mutant of homoprotocatechuate 2,3-dioxygenase from2 brevibacterium fuscum at 1.65a resolution Phyre2 PDB 1knf chain A Region: 2 - 296 Aligned: 286 Modelled: 295 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase Chain: A: PDB Molecule:2,3-dihydroxybiphenyl 1,2-dioxygenase; PDBTitle: crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase complexed2 with 3-methyl catechol under anaerobic condition Phyre2 PDB 1f1u chain B Region: 2 - 295 Aligned: 280 Modelled: 294 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:homoprotocatechuate 2,3-dioxygenase; PDBTitle: crystal structure of homoprotocatechuate 2,3-dioxygenase from2 arthrobacter globiformis (native, low temperature) Phyre2 PDB 5znh chain A Region: 1 - 295 Aligned: 285 Modelled: 288 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:catechol 2,3-dioxygenase, extradiol protein; PDBTitle: catechol 2,3-dioxygenase with 4-methyl catechol from diaphorobacter sp2 ds2 Phyre2 PDB 3b59 chain A Region: 1 - 297 Aligned: 276 Modelled: 283 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:glyoxalase/bleomycin resistance protein/dioxygenase; PDBTitle: crystal structure of the mn(ii)-bound glyoxalase from novosphingobium2 aromaticivorans Phyre2 PDB 3lm4 chain C Region: 1 - 295 Aligned: 281 Modelled: 292 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: C: PDB Molecule:catechol 2,3-dioxygenase; PDBTitle: crystal structure of 2,3-dihydroxy biphenyl dioxygenase from2 rhodococcus sp. (strain rha1) Phyre2 PDB 1mpy chain D Region: 2 - 297 Aligned: 284 Modelled: 287 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: D: PDB Molecule:catechol 2,3-dioxygenase; PDBTitle: structure of catechol 2,3-dioxygenase (metapyrocatechase)2 from pseudomonas putida mt-2 Phyre2 PDB 3hpy chain D Region: 1 - 297 Aligned: 285 Modelled: 297 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: D: PDB Molecule:catechol 2,3-dioxygenase; PDBTitle: crystal structure analysis of the 2,3-dioxygenase lapb from2 pseudomonas in the complex with 4-methylcatechol Phyre2 PDB 1zsw chain A Region: 2 - 297 Aligned: 274 Modelled: 288 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:glyoxalase family protein; PDBTitle: crystal structure of bacillus cereus metallo protein from glyoxalase2 family Phyre2 PDB 4huz chain A Region: 2 - 297 Aligned: 275 Modelled: 290 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:2,6-dichloro-p-hydroquinone 1,2-dioxygenase; PDBTitle: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase Phyre2 PDB 3oaj chain A Region: 2 - 297 Aligned: 262 Modelled: 270 Confidence: 100.0% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative ring-cleaving dioxygenase mhqo; PDBTitle: crystal structure of putative dioxygenase from bacillus subtilis2 subsp. subtilis str. 168 Phyre2 PDB 4ro6 chain A Region: 2 - 270 Aligned: 242 Modelled: 253 Confidence: 100.0% Identity: 12% PDB header:lyase Chain: A: PDB Molecule:lactoylglutathione lyase; PDBTitle: crystal structure of glyoxalase i from zea mays Phyre2 PDB 1kw3 chain B domain 2 Region: 134 - 293 Aligned: 152 Modelled: 160 Confidence: 100.0% Identity: 39% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Extradiol dioxygenases Phyre2 PDB 3zi1 chain A Region: 1 - 290 Aligned: 241 Modelled: 259 Confidence: 100.0% Identity: 14% PDB header:isomerase Chain: A: PDB Molecule:glyoxalase domain-containing protein 4; PDBTitle: crystal structure of human glyoxalase domain-containing protein 42 (glod4) Phyre2 PDB 1lgt chain A domain 2 Region: 134 - 293 Aligned: 152 Modelled: 160 Confidence: 100.0% Identity: 43% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Extradiol dioxygenases Phyre2 1 c2zi8A_ 2 c1kw3B_ 3 c2wl9A_ 4 c2ei2A_ 5 c3vb0D_ 6 c3ecjC_ 7 c1knfA_ 8 c1f1uB_ 9 c5znhA_ 10 c3b59A_ 11 c3lm4C_ 12 c1mpyD_ 13 c3hpyD_ 14 c1zswA_ 15 c4huzA_ 16 c3oajA_ 17 c4ro6A_ 18 d1kw3b2 19 c3zi1A_ 20 d1lgta2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161