1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	T	A	R	S	D	A	P	L	S	V	T	W	M	G	V	A	T	L	L	V	D	D	G	S	S	A	L	M	T	D	G	Y	F	S	R	P	G	L	A	R	V	A	A	G	K	V	S	P	S	A	E	R	V	D	G	C	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	A	N	V	S	R	L	T	A	V	I	P	V	H	T	H	I	D	H	A	M	D	S	A	L	V	A	D	R	T	G	A	Q	L	V	G	G	E	S	A	A	N	V	G	R	G	Y	G	L	P	E	E	S	L	V	V	A	V	P	G
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	P	I	Q	L	G	A	F	D	V	T	L	V	E	S	H	H	C	P	P	D	R	F	P	G	V	I	S	A	P	L	T	P	P	V	K	A	S	A	Y	R	C	G	E	A	W	S	T	L	V	H	H	R	P	S	G	R	R	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	Q	D	S	A	G	F	V	S	G	A	L	A	G	Y	R	A	D	A	A	Y	L	S	V	G	Q	L	G	L	Q	P	P	S	Y	L	L	E	Y	W	T	E	T	V	R	T	V	G	V	R	R	V	I	L	I	H	W	D	D	F	F
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.
Sequence		R	P	L	S	K	P	L	R	A	L	P	Y	A	A	D	D	L	D	L	S	I	R	I	L	D	E	L	A	A	Q	D	G	V	A	L	Q	M	P	T	V	W	R	R	E	D	P	W	M
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?					?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 22%) Beta strand ( 28%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 4qn9 chain A Region: 2 - 285 Aligned: 251 Modelled: 270 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:n-acyl-phosphatidylethanolamine-hydrolyzing phospholipase PDBTitle: structure of human nape-pld Phyre2 PDB 2wyl chain F Region: 2 - 283 Aligned: 245 Modelled: 259 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: F: PDB Molecule:l-ascorbate-6-phosphate lactonase ulag; PDBTitle: apo structure of a metallo-b-lactamase Phyre2 PDB 3bv6 chain D Region: 3 - 262 Aligned: 254 Modelled: 258 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: D: PDB Molecule:metal-dependent hydrolase; PDBTitle: crystal structure of uncharacterized metallo protein from vibrio2 cholerae with beta-lactamase like fold Phyre2 PDB 3rpc chain D Region: 8 - 285 Aligned: 248 Modelled: 263 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: D: PDB Molecule:possible metal-dependent hydrolase; PDBTitle: the crystal structure of a possible metal-dependent hydrolase from2 veillonella parvula dsm 2008 Phyre2 PDB 4jo0 chain A Region: 4 - 277 Aligned: 235 Modelled: 256 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:cmla; PDBTitle: crystal structure of cmla, a diiron beta-hydroxylase from streptomyces2 venezuelae Phyre2 PDB 3kl7 chain A Region: 3 - 277 Aligned: 208 Modelled: 222 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent hydrolase; PDBTitle: crystal structure of putative metal-dependent hydrolase2 (yp_001302908.1) from parabacteroides distasonis atcc 8503 at 2.30 a3 resolution Phyre2 PDB 6brm chain C Region: 10 - 285 Aligned: 249 Modelled: 275 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: C: PDB Molecule:putative metal-dependent isothiocyanate hydrolase saxa; PDBTitle: the crystal structure of isothiocyanate hydrolase from delia radicum2 gut bacteria Phyre2 PDB 1vjn chain A Region: 11 - 259 Aligned: 164 Modelled: 171 Confidence: 100.0% Identity: 19% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: Hypothetical protein TM0207 Phyre2 PDB 3x30 chain A Region: 9 - 285 Aligned: 224 Modelled: 246 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:upf0173 metal-dependent hydrolase tm_1162; PDBTitle: crystal structure of metallo-beta-lactamase from thermotoga maritima Phyre2 PDB 6b9v chain A Region: 9 - 238 Aligned: 183 Modelled: 189 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase-like protein; PDBTitle: crystal structure of a new diphosphatase from the phnp family Phyre2 PDB 1zkp chain D Region: 7 - 263 Aligned: 210 Modelled: 216 Confidence: 99.9% Identity: 21% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein ba1088; PDBTitle: 1.5a resolution crystal structure of a metallo beta lactamase family2 protein, the elac homolgue of bacillus anthracis, a putative3 ribonuclease Phyre2 PDB 3g1p chain A Region: 9 - 237 Aligned: 183 Modelled: 184 Confidence: 99.9% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:protein phnp; PDBTitle: crystals structure of phnp from e.coli k-12 Phyre2 PDB 2xr1 chain A Region: 2 - 234 Aligned: 199 Modelled: 209 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cleavage and polyadenylation specificity factor 100 kd PDBTitle: dimeric archaeal cleavage and polyadenylation specificity2 factor with n-terminal kh domains (kh-cpsf) from methanosarcina3 mazei Phyre2 PDB 1zkp chain A domain 1 Region: 11 - 279 Aligned: 208 Modelled: 210 Confidence: 99.9% Identity: 17% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: YhfI-like Phyre2 PDB 5a0t chain A Region: 2 - 234 Aligned: 203 Modelled: 208 Confidence: 99.9% Identity: 17% PDB header:hydrolase/rna Chain: A: PDB Molecule:ribonuclease j; PDBTitle: catalysis and 5' end sensing by ribonuclease rnase j of the2 metallo-beta-lactamase family Phyre2 PDB 6j4n chain D Region: 1 - 258 Aligned: 213 Modelled: 213 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:metallo-beta-lactamases pngm-1; PDBTitle: structure of papua new guinea mbl-1(pngm-1) native Phyre2 PDB 2xr1 chain B Region: 2 - 234 Aligned: 200 Modelled: 209 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:cleavage and polyadenylation specificity factor 100 kd PDBTitle: dimeric archaeal cleavage and polyadenylation specificity2 factor with n-terminal kh domains (kh-cpsf) from methanosarcina3 mazei Phyre2 PDB 2ycb chain A Region: 2 - 234 Aligned: 199 Modelled: 199 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cleavage and polyadenylation specificity factor; PDBTitle: structure of the archaeal beta-casp protein with n-terminal2 kh domains from methanothermobacter thermautotrophicus Phyre2 PDB 4xww chain A Region: 6 - 234 Aligned: 199 Modelled: 206 Confidence: 99.9% Identity: 16% PDB header:rna binding protein/rna Chain: A: PDB Molecule:dr2417; PDBTitle: crystal structure of rnase j complexed with rna Phyre2 PDB 6i1d chain A Region: 6 - 277 Aligned: 224 Modelled: 238 Confidence: 99.9% Identity: 15% PDB header:gene regulation Chain: A: PDB Molecule:endoribonuclease ysh1; PDBTitle: structure of the ysh1-mpe1 nuclease complex from s.cerevisiae Phyre2 1 c4qn9A_ 2 c2wylF_ 3 c3bv6D_ 4 c3rpcD_ 5 c4jo0A_ 6 c3kl7A_ 7 c6brmC_ 8 d1vjna_ 9 c3x30A_ 10 c6b9vA_ 11 c1zkpD_ 12 c3g1pA_ 13 c2xr1A_ 14 d1zkpa1 15 c5a0tA_ 16 c6j4nD_ 17 c2xr1B_ 18 c2ycbA_ 19 c4xwwA_ 20 c6i1dA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139