1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	T	L	A	V	A	L	I	L	L	A	V	V	L	G	F	A	V	A	R	P	R	G	W	P	E	A	A	A	A	V	P	A	A	V	I	L	L	A	I	G	A	I	S	P	Q	Q	A	M	A	Q	V	S	G	L	A	R	V	V	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	L	G	A	V	L	V	L	A	K	L	C	D	D	E	G	L	F	E	A	A	G	A	A	M	A	R	A	S	A	E	S	H	R	L	L	R	Q	V	F	A	V	S	A	A	I	T	A	A	L	C	L	D	A	T	V	V	L	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	V	V	L	A	T	V	R	R	L	R	T	P	V	R	P	Y	A	Y	A	T	A	H	L	A	N	A	A	S	L	L	L	P	V	S	N	L	T	N	L	L	A	Y	H	G	A	G	I	S	F	T	K	F	T	L	L	M	A	L	P
Secondary structure
SS confidence
Disorder											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	L	S	A	V	A	A	V	Y	V	V	F	R	W	F	F	A	R	D	L	R	V	V	P	D	R	Q	Q	L	K	P	A	P	R	L	P	M	F	V	L	V	V	V	A	L	T	L	G	G	F	A	V	A	E	S	V	G	L	A	P
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?		?	?	?				?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	W	A	A	L	A	G	A	A	V	L	A	L	R	S	L	R	R	G	H	T	S	V	L	R	I	A	R	A	V	N	V	S	F	L	V	F	V	L	A	L	G	V	V	V	H	A	V	M	L	N	G	M	A	A	R	M	S	A	V
Secondary structure
SS confidence
Disorder																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	P	T	G	S	G	L	P	A	L	L	G	I	A	A	L	A	A	V	L	A	N	V	V	N	N	L	P	A	T	L	V	L	V	P	L	V	A	A	G	G	P	A	A	V	L	A	V	L	L	G	V	N	I	G	P	N	L	T	Y
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.
Sequence		A	G	S	L	S	N	L	L	W	R	G	V	L	R	R	H	N	V	D	A	S	V	G	E	Y	T	R	L	G	L	C	T	V	P	A	A	L	A	M	A	V	L	A	L	W	A	S	A	Q	V	L	G	I
Secondary structure
SS confidence
Disorder																																																				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 63%) (View membrane topology prediction)

Rank Aligned region

PDB 4f35 chain C Region: 1 - 409 Aligned: 391 Modelled: 408 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: C: PDB Molecule:transporter, nadc family; PDBTitle: crystal structure of a bacterial dicarboxylate/sodium symporter Phyre2 PDB 4r1i chain B Region: 55 - 413 Aligned: 355 Modelled: 359 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:aminobenzoyl-glutamate transporter; PDBTitle: structure and function of neisseria gonorrhoeae mtrf illuminates a2 class of antimetabolite efflux pumps Phyre2 PDB 4r0c chain B Region: 57 - 410 Aligned: 344 Modelled: 354 Confidence: 99.8% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 4czb chain B Region: 3 - 287 Aligned: 279 Modelled: 285 Confidence: 69.7% Identity: 10% PDB header:membrane protein Chain: B: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: structure of the sodium proton antiporter mjnhap1 from2 methanocaldococcus jannaschii at ph 8. Phyre2 PDB 4bwz chain A Region: 3 - 281 Aligned: 263 Modelled: 279 Confidence: 43.1% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: crystal structure of the sodium proton antiporter, napa Phyre2 PDB 5bz3 chain A Region: 3 - 281 Aligned: 263 Modelled: 279 Confidence: 43.1% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: crystal structure of sodium proton antiporter napa in outward-facing2 conformation. Phyre2 PDB 3qnq chain D Region: 135 - 210 Aligned: 76 Modelled: 76 Confidence: 23.7% Identity: 11% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 2bbj chain B Region: 158 - 200 Aligned: 40 Modelled: 43 Confidence: 16.7% Identity: 15% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 5a1s chain B Region: 2 - 324 Aligned: 298 Modelled: 308 Confidence: 11.9% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 1ar1 chain B Region: 173 - 235 Aligned: 63 Modelled: 63 Confidence: 8.9% Identity: 8% PDB header:complex (oxidoreductase/antibody) Chain: B: PDB Molecule:cytochrome c oxidase; PDBTitle: structure at 2.7 angstrom resolution of the paracoccus2 denitrificans two-subunit cytochrome c oxidase complexed3 with an antibody fv fragment Phyre2 PDB 1qle chain B Region: 173 - 235 Aligned: 63 Modelled: 63 Confidence: 8.9% Identity: 8% PDB header:oxidoreductase/immune system Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: cryo-structure of the paracoccus denitrificans four-subunit cytochrome2 c oxidase in the completely oxidized state complexed with an antibody3 fv fragment Phyre2 PDB 1m57 chain H Region: 173 - 235 Aligned: 63 Modelled: 63 Confidence: 7.9% Identity: 5% PDB header:oxidoreductase Chain: H: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobacter2 sphaeroides (eq(i-286) mutant)) Phyre2 PDB 1fft chain B domain 2 Region: 169 - 235 Aligned: 67 Modelled: 67 Confidence: 7.2% Identity: 15% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 2knc chain A Region: 173 - 211 Aligned: 39 Modelled: 39 Confidence: 6.1% Identity: 15% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 4us3 chain A Region: 98 - 235 Aligned: 138 Modelled: 138 Confidence: 5.4% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:transporter; PDBTitle: crystal structure of the bacterial nss member mhst in an2 occluded inward-facing state Phyre2 1 c4f35C_ 2 c4r1iB_ 3 c4r0cB_ 4 c4czbB_ 5 c4bwzA_ 6 c5bz3A_ 7 c3qnqD_ 8 c2bbjB_ 9 c5a1sB_ 10 c1ar1B_ 11 c1qleB_ 12 c1m57H_ 13 d1fftb2 14 c2kncA_ 15 c4us3A_