1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	G	N	S	R	R	R	G	A	V	R	K	S	G	T	K	K	G	A	G	V	G	S	G	G	Q	R	R	R	G	L	E	G	R	G	P	T	P	P	A	H	L	R	P	H	H	P	A	A	K	R	A	R	A	Q	P	R	R	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	K	R	A	D	E	T	E	T	V	L	G	R	N	P	V	L	E	C	L	R	A	G	V	P	A	T	A	L	Y	V	A	L	G	T	E	A	D	E	R	L	T	E	C	V	A	R	A	A	D	S	G	I	A	I	V	E	L	L	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	D	L	D	R	M	T	A	N	H	L	H	Q	G	I	A	L	Q	V	P	P	Y	N	Y	A	H	P	D	D	L	L	A	A	A	L	D	Q	P	P	A	L	L	V	A	L	D	N	L	S	D	P	R	N	L	G	A	I	V	R	S
Secondary structure
SS confidence
Disorder									?														?	?										?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	A	A	F	G	G	H	G	V	L	I	P	Q	R	R	S	A	S	V	T	A	V	A	W	R	T	S	A	G	A	A	A	R	I	P	V	A	R	A	T	N	L	T	R	T	L	K	G	W	A	D	R	G	V	R	V	I	G	L	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	G	G	G	T	A	L	D	D	V	D	G	T	D	S	L	V	V	V	V	G	S	E	G	K	G	L	S	R	L	V	R	Q	N	C	D	E	V	V	S	I	P	M	A	A	Q	A	E	S	L	N	A	S	V	A	A	G	V	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Sequence		A	E	I	A	R	Q	R	R	R	P	R	E	P	R	E	Q	T	Q	N	R	M	I
Secondary structure
SS confidence
Disorder							?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 32%) Beta strand ( 17%)

Rank Aligned region

PDB 1gz0 chain H Region: 60 - 307 Aligned: 247 Modelled: 238 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: H: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 3gyq chain B Region: 45 - 310 Aligned: 256 Modelled: 256 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex Phyre2 PDB 1ipa chain A Region: 45 - 308 Aligned: 252 Modelled: 252 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase Phyre2 PDB 4x3m chain B Region: 45 - 310 Aligned: 252 Modelled: 252 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:rna 2'-o ribose methyltransferase; PDBTitle: crystal structure of ttha0275 from thermus thermophilus (hb8) in2 complex with adenosine in space group p212121 Phyre2 PDB 5kzk chain A Region: 45 - 309 Aligned: 252 Modelled: 247 Confidence: 100.0% Identity: 24% PDB header:rna binding protein Chain: A: PDB Molecule:probable rna methyltransferase, trmh family; PDBTitle: crystal structure of rrna methyltransferase from sinorhizobium2 meliloti Phyre2 PDB 1x7p chain B Region: 47 - 307 Aligned: 244 Modelled: 244 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet Phyre2 PDB 2i6d chain A Region: 48 - 306 Aligned: 242 Modelled: 237 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. Phyre2 PDB 1gz0 chain A domain 1 Region: 140 - 307 Aligned: 165 Modelled: 166 Confidence: 100.0% Identity: 41% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1gz0 chain G Region: 140 - 307 Aligned: 165 Modelled: 158 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1zjr chain A Region: 147 - 313 Aligned: 166 Modelled: 166 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:trna (guanosine-2'-o-)-methyltransferase; PDBTitle: crystal structure of a. aeolicus trmh/spou trna modifying enzyme Phyre2 PDB 5co4 chain A Region: 157 - 308 Aligned: 150 Modelled: 150 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:putative trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: structural insights into the 2-oh methylation of c/u34 on trna Phyre2 PDB 1v2x chain A Region: 139 - 311 Aligned: 171 Modelled: 171 Confidence: 100.0% Identity: 27% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1ipa chain A domain 1 Region: 151 - 309 Aligned: 157 Modelled: 157 Confidence: 100.0% Identity: 27% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 2ha8 chain A Region: 154 - 310 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 21% PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 Phyre2 PDB 4pzk chain A Region: 161 - 311 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: crystal strucrure of putative rna methyltransferase from bacillus2 anthracis. Phyre2 PDB 1mxi chain A Region: 161 - 314 Aligned: 152 Modelled: 152 Confidence: 100.0% Identity: 20% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 3onp chain A Region: 160 - 306 Aligned: 147 Modelled: 142 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:trna/rrna methyltransferase (spou); PDBTitle: crystal structure of trna/rrna methyltransferase spou from rhodobacter2 sphaeroides Phyre2 PDB 3ic6 chain A Region: 160 - 313 Aligned: 154 Modelled: 152 Confidence: 100.0% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative methylase family protein; PDBTitle: crystal structure of putative methylase family protein from neisseria2 gonorrhoeae Phyre2 PDB 5gm8 chain A Region: 160 - 307 Aligned: 148 Modelled: 147 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine/uridine-2'-o-)-methyltransferase trmj; PDBTitle: methylation at position 32 of trna catalyzed by trmj alters oxidative2 stress response in pseudomonas aeruiginosa Phyre2 PDB 3e5y chain B Region: 161 - 311 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:trmh family rna methyltransferase; PDBTitle: crystal structure of trmh family rna methyltransferase from2 burkholderia pseudomallei Phyre2 1 c1gz0H_ 2 c3gyqB_ 3 c1ipaA_ 4 c4x3mB_ 5 c5kzkA_ 6 c1x7pB_ 7 c2i6dA_ 8 d1gz0a1 9 c1gz0G_ 10 c1zjrA_ 11 c5co4A_ 12 d1v2xa_ 13 d1ipaa1 14 c2ha8A_ 15 c4pzkA_ 16 d1mxia_ 17 c3onpA_ 18 c3ic6A_ 19 c5gm8A_ 20 c3e5yB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175