1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	Q	L	P	R	V	G	L	G	T	D	V	H	P	I	E	P	G	R	P	C	W	L	V	G	L	L	F	P	S	A	D	G	C	A	G	H	S	D	G	D	V	A	V	H	A	L	C	D	A	V	L	S	A	A	G	L	G	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	G	E	V	F	G	V	D	D	P	R	W	Q	G	V	S	G	A	D	M	L	R	H	V	V	V	L	I	T	Q	H	G	Y	R	V	G	N	A	V	V	Q	V	I	G	N	R	P	K	I	G	W	R	R	L	E	A	Q	A	V	L
Secondary structure
SS confidence
Disorder																																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.
Sequence		S	R	L	L	N	A	P	V	S	V	S	A	T	T	T	D	G	L	G	L	T	G	R	G	E	G	L	A	A	I	A	T	A	L	V	V	S	L	R
Secondary structure
SS confidence
Disorder							?												?		?	?																	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 30%) Beta strand ( 36%)

Rank Aligned region

PDB 3f0g chain A Region: 3 - 157 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 41% PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate2 synthase with cmp Phyre2 PDB 2pmp chain A Region: 2 - 157 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 37% PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from2 the isoprenoid biosynthetic pathway of arabidopsis thaliana Phyre2 PDB 1gx1 chain A Region: 5 - 157 Aligned: 153 Modelled: 152 Confidence: 100.0% Identity: 42% Fold: Bacillus chorismate mutase-like Superfamily: IpsF-like Family: IpsF-like Phyre2 PDB 1t0a chain A Region: 5 - 157 Aligned: 153 Modelled: 153 Confidence: 100.0% Identity: 41% Fold: Bacillus chorismate mutase-like Superfamily: IpsF-like Family: IpsF-like Phyre2 PDB 1w57 chain A Region: 2 - 158 Aligned: 157 Modelled: 157 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:ispd/ispf bifunctional enzyme; PDBTitle: structure of the bifunctional ispdf from campylobacter2 jejuni containing zn Phyre2 PDB 1w55 chain A domain 2 Region: 3 - 159 Aligned: 157 Modelled: 157 Confidence: 100.0% Identity: 32% Fold: Bacillus chorismate mutase-like Superfamily: IpsF-like Family: IpsF-like Phyre2 PDB 2uzh chain B Region: 4 - 157 Aligned: 152 Modelled: 154 Confidence: 100.0% Identity: 75% PDB header:lyase Chain: B: PDB Molecule:2c-methyl-d-erythritol 2,4-cyclodiphosphate PDBTitle: mycobacterium smegmatis 2c-methyl-d-erythritol-2,4-2 cyclodiphosphate synthase (ispf) Phyre2 PDB 1iv3 chain A Region: 6 - 156 Aligned: 147 Modelled: 151 Confidence: 100.0% Identity: 43% Fold: Bacillus chorismate mutase-like Superfamily: IpsF-like Family: IpsF-like Phyre2 PDB 1vh8 chain A Region: 4 - 157 Aligned: 148 Modelled: 154 Confidence: 100.0% Identity: 42% Fold: Bacillus chorismate mutase-like Superfamily: IpsF-like Family: IpsF-like Phyre2 PDB 5iwy chain D Region: 4 - 157 Aligned: 146 Modelled: 154 Confidence: 100.0% Identity: 41% PDB header:lyase Chain: D: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate2 synthase from bacillus subtitis complexed with cmp and mg2+ Phyre2 PDB 4c82 chain A Region: 5 - 157 Aligned: 144 Modelled: 145 Confidence: 100.0% Identity: 33% PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: ispf (plasmodium falciparum) unliganded structure Phyre2 PDB 3re3 chain B Region: 5 - 157 Aligned: 138 Modelled: 153 Confidence: 100.0% Identity: 36% PDB header:lyase Chain: B: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate2 synthase from francisella tularensis Phyre2 PDB 3b6n chain A Region: 5 - 159 Aligned: 139 Modelled: 140 Confidence: 100.0% Identity: 31% PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate2 synthase pv003920 from plasmodium vivax Phyre2 PDB 5esz chain G Region: 3 - 157 Aligned: 115 Modelled: 138 Confidence: 100.0% Identity: 32% PDB header:immune system Chain: G: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, PDBTitle: crystal structure of broadly neutralizing antibody ch04, isolated from2 donor ch0219, in complex with scaffolded trimeric hiv-1 env v1v23 domain from the clade ae strain a244 Phyre2 PDB 3nbm chain A Region: 74 - 130 Aligned: 54 Modelled: 57 Confidence: 45.7% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:pts system, lactose-specific iibc components; PDBTitle: the lactose-specific iib component domain structure of the2 phosphoenolpyruvate:carbohydrate phosphotransferase system (pts) from3 streptococcus pneumoniae. Phyre2 PDB 6epz chain A Region: 47 - 133 Aligned: 86 Modelled: 87 Confidence: 40.6% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:periplasmic alpha-galactoside-binding protein; PDBTitle: structure of the periplasmic binding protein melb (atu4661) in complex2 with melibiose from agrobacterium fabrum c58 Phyre2 PDB 6i3g chain A Region: 47 - 134 Aligned: 87 Modelled: 88 Confidence: 40.2% Identity: 9% PDB header:peptide binding protein Chain: A: PDB Molecule:abc transporter, substrate-binding protein, family 5; PDBTitle: crystal structure of a putative peptide binding protein appa from2 clostridium difficile Phyre2 PDB 1w25 chain B Region: 37 - 124 Aligned: 84 Modelled: 88 Confidence: 38.1% Identity: 11% PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp Phyre2 PDB 4ony chain B Region: 81 - 134 Aligned: 53 Modelled: 54 Confidence: 35.5% Identity: 21% PDB header:transport protein Chain: B: PDB Molecule:extracellular solute-binding protein family 5; PDBTitle: crystal structure of a abc transporter, periplasmic substrate-binding2 protein from brucella melitensis Phyre2 PDB 1r57 chain A Region: 69 - 96 Aligned: 28 Modelled: 28 Confidence: 35.4% Identity: 18% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: N-acetyl transferase, NAT Phyre2 1 c3f0gA_ 2 c2pmpA_ 3 d1gx1a_ 4 d1t0aa_ 5 c1w57A_ 6 d1w55a2 7 c2uzhB_ 8 d1iv3a_ 9 d1vh8a_ 10 c5iwyD_ 11 c4c82A_ 12 c3re3B_ 13 c3b6nA_ 14 c5eszG_ 15 c3nbmA_ 16 c6epzA_ 17 c6i3gA_ 18 c1w25B_ 19 c4onyB_ 20 d1r57a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99