1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	A	V	T	R	P	T	L	R	E	A	V	A	R	L	A	P	G	T	G	L	R	D	G	L	E	R	I	L	R	G	R	T	G	A	L	I	V	L	G	H	D	E	N	V	E	A	I	C	D	G	G	F	S	L	D	V	R	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?											?	?	?	?															?																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	T	R	L	R	E	L	C	K	M	D	G	A	V	V	L	S	T	D	G	S	R	I	V	R	A	N	V	Q	L	V	P	D	P	S	I	P	T	D	E	S	G	T	R	H	R	S	A	E	R	A	A	I	Q	T	G	Y	P	V
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	S	V	S	H	S	M	N	I	V	T	V	Y	V	R	G	E	R	H	V	L	T	D	S	A	T	I	L	S	R	A	N	Q	A	I	A	T	L	E	R	Y	K	T	R	L	D	E	V	S	R	Q	L	S	R	A	E	I	E	D	F
Secondary structure
SS confidence
Disorder						?																		?														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	T	L	R	D	V	M	T	V	V	Q	R	L	E	L	V	R	R	I	G	L	V	I	D	Y	D	V	V	E	L	G	T	D	G	R	Q	L	R	L	Q	L	D	E	L	L	G	G	N	D	T	A	R	E	L	I	V	R	D	Y	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	N	P	E	P	P	S	T	G	Q	I	N	A	T	L	D	E	L	D	A	L	S	D	G	D	L	L	D	F	T	A	L	A	K	V	F	G	Y	P	T	T	T	E	A	Q	D	S	T	L	S	P	R	G	Y	R	A	M	A	G	I
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?																		?	?	?												?	?	?	?	?	?	?	?	?				?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.
Sequence		P	R	L	Q	F	A	H	A	D	L	L	V	R	A	F	G	T	L	Q	G	L	L	A	A	S	A	G	D	L	Q	S	V	D	G	I	G	A	M	W	A	R	H	V	R	E	G	L	S	Q	L	A	E	S	T	I	S	D	Q
Secondary structure
SS confidence
Disorder			?	?	?																			?	?								?		?	?	?															?	?	?		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 58%) Beta strand ( 11%)

Rank Aligned region

PDB 3c1z chain A Region: 6 - 353 Aligned: 343 Modelled: 348 Confidence: 100.0% Identity: 39% PDB header:dna binding protein Chain: A: PDB Molecule:dna integrity scanning protein disa; PDBTitle: structure of the ligand-free form of a bacterial dna damage sensor2 protein Phyre2 PDB 2fb5 chain A domain 1 Region: 14 - 142 Aligned: 127 Modelled: 127 Confidence: 100.0% Identity: 27% Fold: YojJ-like Superfamily: YojJ-like Family: YojJ-like Phyre2 PDB 4rv7 chain C Region: 5 - 158 Aligned: 146 Modelled: 154 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: C: PDB Molecule:diadenylate cyclase; PDBTitle: characterization of an essential diadenylate cyclase Phyre2 PDB 6gyy chain B Region: 21 - 155 Aligned: 133 Modelled: 135 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:diadenylate cyclase; PDBTitle: crystal structure of daca from staphylococcus aureus, n166c/t172c2 double mutant Phyre2 PDB 2mut chain A Region: 291 - 351 Aligned: 61 Modelled: 61 Confidence: 98.9% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:dna excision repair protein ercc-1; PDBTitle: solution structure of the f231l mutant ercc1-xpf dimerization region Phyre2 PDB 2a1j chain B domain 1 Region: 291 - 354 Aligned: 64 Modelled: 64 Confidence: 98.8% Identity: 25% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 1x2i chain A domain 1 Region: 288 - 351 Aligned: 64 Modelled: 64 Confidence: 98.7% Identity: 28% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 1dgs chain B Region: 280 - 358 Aligned: 73 Modelled: 79 Confidence: 98.6% Identity: 29% PDB header:ligase Chain: B: PDB Molecule:dna ligase; PDBTitle: crystal structure of nad+-dependent dna ligase from t.2 filiformis Phyre2 PDB 2owo chain A Region: 280 - 358 Aligned: 73 Modelled: 79 Confidence: 98.6% Identity: 29% PDB header:ligase/dna Chain: A: PDB Molecule:dna ligase; PDBTitle: last stop on the road to repair: structure of e.coli dna ligase bound2 to nicked dna-adenylate Phyre2 PDB 2bgw chain A domain 1 Region: 287 - 351 Aligned: 65 Modelled: 65 Confidence: 98.6% Identity: 22% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 1v9p chain B Region: 280 - 358 Aligned: 73 Modelled: 79 Confidence: 98.6% Identity: 29% PDB header:ligase Chain: B: PDB Molecule:dna ligase; PDBTitle: crystal structure of nad+-dependent dna ligase Phyre2 PDB 1kft chain A Region: 297 - 349 Aligned: 53 Modelled: 53 Confidence: 98.6% Identity: 26% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Excinuclease UvrC C-terminal domain Phyre2 PDB 1kft chain A Region: 297 - 349 Aligned: 53 Modelled: 53 Confidence: 98.6% Identity: 26% PDB header:dna binding protein Chain: A: PDB Molecule:excinuclease abc subunit c; PDBTitle: solution structure of the c-terminal domain of uvrc from e-2 coli Phyre2 PDB 1dgs chain A domain 1 Region: 280 - 358 Aligned: 73 Modelled: 73 Confidence: 98.5% Identity: 29% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: NAD+-dependent DNA ligase, domain 3 Phyre2 PDB 4glx chain A Region: 280 - 358 Aligned: 73 Modelled: 79 Confidence: 98.5% Identity: 29% PDB header:ligase/ligase inhibitor/dna Chain: A: PDB Molecule:dna ligase; PDBTitle: dna ligase a in complex with inhibitor Phyre2 PDB 2aq0 chain A domain 1 Region: 279 - 357 Aligned: 78 Modelled: 79 Confidence: 98.5% Identity: 17% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2bhn chain D Region: 294 - 352 Aligned: 59 Modelled: 59 Confidence: 98.5% Identity: 22% PDB header:hydrolase Chain: D: PDB Molecule:xpf endonuclease; PDBTitle: xpf from aeropyrum pernix Phyre2 PDB 4bxo chain A Region: 294 - 356 Aligned: 63 Modelled: 63 Confidence: 98.4% Identity: 10% PDB header:hydrolase/dna Chain: A: PDB Molecule:fanconi anemia group m protein; PDBTitle: architecture and dna recognition elements of the fanconi anemia fancm-2 faap24 complex Phyre2 PDB 2lyh chain A Region: 291 - 351 Aligned: 59 Modelled: 61 Confidence: 98.2% Identity: 31% PDB header:dna binding protein Chain: A: PDB Molecule:fanconi anemia-associated protein of 24 kda; PDBTitle: structure of faap24 residues 141-215 Phyre2 PDB 4bxo chain B Region: 294 - 350 Aligned: 55 Modelled: 57 Confidence: 98.2% Identity: 31% PDB header:hydrolase/dna Chain: B: PDB Molecule:fanconi anemia-associated protein of 24 kda; PDBTitle: architecture and dna recognition elements of the fanconi anemia fancm-2 faap24 complex Phyre2 1 c3c1zA_ 2 d2fb5a1 3 c4rv7C_ 4 c6gyyB_ 5 c2mutA_ 6 d2a1jb1 7 d1x2ia1 8 c1dgsB_ 9 c2owoA_ 10 d2bgwa1 11 c1v9pB_ 12 d1kfta_ 13 c1kftA_ 14 d1dgsa1 15 c4glxA_ 16 d2aq0a1 17 c2bhnD_ 18 c4bxoA_ 19 c2lyhA_ 20 c4bxoB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183