1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	I	P	A	F	H	P	G	E	L	N	V	Y	S	A	P	G	D	V	A	D	V	S	R	A	L	R	L	T	G	R	R	V	M	L	V	P	T	M	G	A	L	H	E	G	H	L	A	L	V	R	A	A	K	R	V	P	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	V	V	V	S	I	F	V	N	P	M	Q	F	G	A	G	E	D	L	D	A	Y	P	R	T	P	D	D	D	L	A	Q	L	R	A	E	G	V	E	I	A	F	T	P	T	T	A	A	M	Y	P	D	G	L	R	T	T	V	Q	P
Secondary structure
SS confidence
Disorder																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	P	L	A	A	E	L	E	G	G	P	R	P	T	H	F	A	G	V	L	T	V	V	L	K	L	L	Q	I	V	R	P	D	R	V	F	F	G	E	K	D	Y	Q	Q	L	V	L	I	R	Q	L	V	A	D	F	N	L	D	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	V	G	V	P	T	V	R	E	A	D	G	L	A	M	S	S	R	N	R	Y	L	D	P	A	Q	R	A	A	A	V	A	L	S	A	A	L	T	A	A	A	H	A	A	T	A	G	A	Q	A	A	L	D	A	A	R	A	V	L	D
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	P	G	V	A	V	D	Y	L	E	L	R	D	I	G	L	G	P	M	P	L	N	G	S	G	R	L	L	V	A	A	R	L	G	T	T	R	L	L	D	N	I	A	I	E	I	G	T	F	A	G	T	D	R	P	D	G	Y	R
Secondary structure
SS confidence
Disorder																			?		?	?	?																										?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		A	I	L	E	S	H	W	R	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 37%) Beta strand ( 24%)

Rank Aligned region

PDB 2a84 chain A domain 1 Region: 3 - 288 Aligned: 276 Modelled: 286 Confidence: 100.0% Identity: 100% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) Phyre2 PDB 2ejc chain A Region: 11 - 285 Aligned: 274 Modelled: 275 Confidence: 100.0% Identity: 41% PDB header:ligase Chain: A: PDB Molecule:pantoate--beta-alanine ligase; PDBTitle: crystal structure of pantoate--beta-alanine ligase (panc)2 from thermotoga maritima Phyre2 PDB 1iho chain A Region: 11 - 287 Aligned: 275 Modelled: 277 Confidence: 100.0% Identity: 45% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) Phyre2 PDB 3mxt chain A Region: 10 - 287 Aligned: 276 Modelled: 278 Confidence: 100.0% Identity: 36% PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantoate-beta-alanine ligase from campylobacter2 jejuni Phyre2 PDB 3ag5 chain A Region: 11 - 287 Aligned: 271 Modelled: 277 Confidence: 100.0% Identity: 40% PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantothenate synthetase from staphylococcus2 aureus Phyre2 PDB 1v8f chain A Region: 11 - 286 Aligned: 270 Modelled: 276 Confidence: 100.0% Identity: 46% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) Phyre2 PDB 3uk2 chain B Region: 10 - 285 Aligned: 271 Modelled: 276 Confidence: 100.0% Identity: 44% PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: the structure of pantothenate synthetase from burkholderia2 thailandensis Phyre2 PDB 3inn chain B Region: 10 - 286 Aligned: 267 Modelled: 277 Confidence: 100.0% Identity: 44% PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantoate-beta-alanine-ligase in complex2 with atp at low occupancy at 2.1 a resolution Phyre2 PDB 3n8h chain A Region: 11 - 290 Aligned: 259 Modelled: 279 Confidence: 100.0% Identity: 37% PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantoate-beta-alanine ligase from francisella2 tularensis Phyre2 PDB 5kwv chain A Region: 10 - 288 Aligned: 264 Modelled: 279 Confidence: 100.0% Identity: 47% PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of a pantoate-beta-alanine ligase from neisseria2 gonorrhoeae with bound amppnp Phyre2 PDB 3guz chain B Region: 11 - 185 Aligned: 167 Modelled: 175 Confidence: 100.0% Identity: 48% PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: structural and substrate-binding studies of pantothenate2 synthenate (ps)provide insights into homotropic inhibition3 by pantoate in ps's Phyre2 PDB 2x0k chain B Region: 11 - 112 Aligned: 96 Modelled: 102 Confidence: 97.9% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribf; PDBTitle: crystal structure of modular fad synthetase from2 corynebacterium ammoniagenes Phyre2 PDB 5xf2 chain B Region: 14 - 105 Aligned: 88 Modelled: 92 Confidence: 97.4% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:putative cytidylyltransferase; PDBTitle: crystal structure of semet-hldc from burkholderia pseudomallei Phyre2 PDB 3glv chain B Region: 32 - 185 Aligned: 117 Modelled: 121 Confidence: 97.0% Identity: 20% PDB header:biosynthetic protein Chain: B: PDB Molecule:lipopolysaccharide core biosynthesis protein; PDBTitle: crystal structure of the lipopolysaccharide core biosynthesis protein2 from thermoplasma volcanium gss1 Phyre2 PDB 3gmi chain A Region: 15 - 173 Aligned: 130 Modelled: 138 Confidence: 96.8% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0348 protein mj0951; PDBTitle: crystal structure of a protein of unknown function from2 methanocaldococcus jannaschii Phyre2 PDB 3elb chain A Region: 29 - 109 Aligned: 73 Modelled: 80 Confidence: 96.4% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:ethanolamine-phosphate cytidylyltransferase; PDBTitle: human ctp: phosphoethanolamine cytidylyltransferase in complex with2 cmp Phyre2 PDB 1coz chain A Region: 32 - 111 Aligned: 76 Modelled: 80 Confidence: 96.3% Identity: 21% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Cytidylyltransferase Phyre2 PDB 4zcs chain E Region: 32 - 110 Aligned: 77 Modelled: 79 Confidence: 96.1% Identity: 16% PDB header:transferase Chain: E: PDB Molecule:choline-phosphate cytidylyltransferase; PDBTitle: crystal structure of the c-terminal catalytic domain of plasmodium2 falciparum ctp:phosphocholine cytidylyltransferase in complex with3 cdp-choline Phyre2 PDB 3op1 chain A Region: 31 - 103 Aligned: 72 Modelled: 73 Confidence: 96.1% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:macrolide-efflux protein; PDBTitle: crystal structure of macrolide-efflux protein sp_1110 from2 streptococcus pneumoniae Phyre2 PDB 1qjc chain A Region: 32 - 99 Aligned: 59 Modelled: 68 Confidence: 95.9% Identity: 19% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Adenylyltransferase Phyre2 1 d2a84a1 2 c2ejcA_ 3 d1ihoa_ 4 c3mxtA_ 5 c3ag5A_ 6 d1v8fa_ 7 c3uk2B_ 8 c3innB_ 9 c3n8hA_ 10 c5kwvA_ 11 c3guzB_ 12 c2x0kB_ 13 c5xf2B_ 14 c3glvB_ 15 c3gmiA_ 16 c3elbA_ 17 d1coza_ 18 c4zcsE_ 19 c3op1A_ 20 d1qjca_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165