1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	V	V	L	S	V	G	S	N	L	G	D	R	L	A	R	L	R	S	V	A	D	G	L	G	D	A	L	I	A	A	S	P	I	Y	E	A	D	P	W	G	G	V	E	Q	G	Q	F	L	N	A	V	L	I	A	D	D	P
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	C	E	P	R	E	W	L	R	R	A	Q	E	F	E	R	A	A	G	R	V	R	G	Q	R	W	G	P	R	N	L	D	V	D	L	I	A	C	Y	Q	T	S	A	T	E	A	L	V	E	V	T	A	R	E	N	H	L	T	L	P
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	P	L	A	H	L	R	A	F	V	L	I	P	W	I	A	V	D	P	T	A	Q	L	T	V	A	G	C	P	R	P	V	T	R	L	L	A	E	L	E	P	A	D	R	D	S	V	R	L	F	R	P	S	F	D	L	N	S	R	H
Secondary structure
SS confidence
Disorder																																													?										?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		P	V	S	R	A	P	E	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 26%) Beta strand ( 21%)

Rank Aligned region

PDB 1cbk chain A Region: 1 - 169 Aligned: 154 Modelled: 169 Confidence: 100.0% Identity: 30% Fold: Ferredoxin-like Superfamily: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK Family: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK Phyre2 PDB 3qbc chain B Region: 1 - 164 Aligned: 152 Modelled: 164 Confidence: 100.0% Identity: 35% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine PDBTitle: structure and design of a new pterin site inhibitor of s. aureus hppk Phyre2 PDB 2qx0 chain A Region: 1 - 170 Aligned: 154 Modelled: 158 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:7,8-dihydro-6-hydroxymethylpterin- PDBTitle: crystal structure of yersinia pestis hppk (ternary complex) Phyre2 PDB 1f9y chain A Region: 2 - 170 Aligned: 153 Modelled: 159 Confidence: 100.0% Identity: 29% Fold: Ferredoxin-like Superfamily: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK Family: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK Phyre2 PDB 2bmb chain A Region: 2 - 171 Aligned: 155 Modelled: 170 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:folic acid synthesis protein fol1; PDBTitle: x-ray structure of the bifunctional 6-hydroxymethyl-7,8-2 dihydroxypterin pyrophosphokinase dihydropteroate synthase from3 saccharomyces cerevisiae Phyre2 PDB 3mcn chain A Region: 1 - 159 Aligned: 136 Modelled: 159 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine PDBTitle: crystal structure of the 6-hyroxymethyl-7,8-dihydropterin2 pyrophosphokinase dihydropteroate synthase bifunctional enzyme from3 francisella tularensis Phyre2 PDB 2cg8 chain B Region: 2 - 158 Aligned: 129 Modelled: 149 Confidence: 100.0% Identity: 29% PDB header:lyase/transferase Chain: B: PDB Molecule:dihydroneopterin aldolase 6-hydroxymethyl-7,8- PDBTitle: the bifunctional dihydroneopterin aldolase 6-hydroxymethyl-2 7,8-dihydropterin synthase from streptococcus pneumoniae Phyre2 PDB 5z79 chain F Region: 50 - 159 Aligned: 99 Modelled: 110 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: F: PDB Molecule:hydroxymethyldihydropterin pyrophosphokinase- PDBTitle: crystal structure analysis of the hppk-dhps in complex with substrates Phyre2 PDB 6ohk chain A Region: 1 - 33 Aligned: 33 Modelled: 33 Confidence: 22.7% Identity: 9% PDB header:electron transport Chain: A: PDB Molecule:flavodoxin; PDBTitle: crystal structure of fusobacterium nucleatum flavodoxin mutant k13g2 bound to flavin mononucleotide Phyre2 PDB 2m6r chain A Region: 1 - 26 Aligned: 26 Modelled: 26 Confidence: 20.7% Identity: 23% PDB header:electron transport Chain: A: PDB Molecule:flavodoxin; PDBTitle: apo_yqca Phyre2 PDB 2bcg chain G domain 3 Region: 2 - 38 Aligned: 37 Modelled: 37 Confidence: 16.8% Identity: 16% Fold: FAD-linked reductases, C-terminal domain Superfamily: FAD-linked reductases, C-terminal domain Family: GDI-like Phyre2 PDB 2wc1 chain A Region: 1 - 27 Aligned: 27 Modelled: 27 Confidence: 16.0% Identity: 22% PDB header:electron transport Chain: A: PDB Molecule:flavodoxin; PDBTitle: three-dimensional structure of the nitrogen fixation2 flavodoxin (niff) from rhodobacter capsulatus at 2.2 a Phyre2 PDB 5f4b chain B Region: 1 - 33 Aligned: 33 Modelled: 33 Confidence: 14.5% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p)h dehydrogenase (quinone); PDBTitle: structure of b. abortus wrba-related protein a (wrpa) Phyre2 PDB 5ns5 chain A Region: 10 - 95 Aligned: 86 Modelled: 86 Confidence: 14.1% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:dipeptidase glij; PDBTitle: cys-gly dipeptidase glij in complex with cu2+ and zn2+ Phyre2 PDB 2inp chain D Region: 73 - 94 Aligned: 22 Modelled: 22 Confidence: 12.0% Identity: 18% PDB header:oxidoreductase Chain: D: PDB Molecule:phenol hydroxylase component phl; PDBTitle: structure of the phenol hydroxylase-regulatory protein2 complex Phyre2 PDB 5f5m chain B Region: 9 - 25 Aligned: 17 Modelled: 17 Confidence: 11.8% Identity: 41% PDB header:nuclear protein Chain: B: PDB Molecule:nucleoprotein; PDBTitle: crystal structure of marburg virus nucleoprotein core domain Phyre2 PDB 6o58 chain C Region: 92 - 173 Aligned: 55 Modelled: 68 Confidence: 11.5% Identity: 27% PDB header:transport protein Chain: C: PDB Molecule:calcium uniporter protein, mitochondrial; PDBTitle: human mcu-emre complex, dimer of channel Phyre2 PDB 1d5t chain A domain 2 Region: 4 - 38 Aligned: 35 Modelled: 35 Confidence: 11.1% Identity: 20% Fold: FAD-linked reductases, C-terminal domain Superfamily: FAD-linked reductases, C-terminal domain Family: GDI-like Phyre2 PDB 1unv chain B Region: 65 - 83 Aligned: 19 Modelled: 19 Confidence: 10.9% Identity: 21% PDB header:four helix bundle Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: structure based engineering of internal molecular surfaces of four2 helix bundles Phyre2 PDB 1unv chain A Region: 65 - 83 Aligned: 19 Modelled: 19 Confidence: 10.9% Identity: 21% PDB header:four helix bundle Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: structure based engineering of internal molecular surfaces of four2 helix bundles Phyre2 1 d1cbka_ 2 c3qbcB_ 3 c2qx0A_ 4 d1f9ya_ 5 c2bmbA_ 6 c3mcnA_ 7 c2cg8B_ 8 c5z79F_ 9 c6ohkA_ 10 c2m6rA_ 11 d2bcgg3 12 c2wc1A_ 13 c5f4bB_ 14 c5ns5A_ 15 c2inpD_ 16 c5f5mB_ 17 c6o58C_ 18 d1d5ta2 19 c1unvB_ 20 c1unvA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47