1

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10

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20

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30

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40

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.

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.

50

.

.

.

Sequence

M

C

T

M

P

K

L

W

R

A

F

M

A

G

R

P

L

G

S

T

F

T

P

R

Q

P

T

G

A

A

P

N

H

V

R

A

L

D

D

S

I

D

P

S

S

A

P

A

A

R

A

A

L

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 53%) Alpha helix ( 43%) Beta strand ( 0%)

Rank Aligned region

PDB 1z9i chain A Region: 18 - 36 Aligned: 19 Modelled: 19 Confidence: 10.5% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:epidermal growth factor receptor; PDBTitle: a structural model for the membrane-bound form of the2 juxtamembrane domain of the epidermal growth factor3 receptor Phyre2 PDB 2l1q chain A Region: 4 - 18 Aligned: 14 Modelled: 15 Confidence: 8.2% Identity: 43% PDB header:antimicrobial protein Chain: A: PDB Molecule:liver-expressed antimicrobial peptide 2; PDBTitle: solution structure of human liver expressed antimicrobial peptide 2 Phyre2 PDB 3udi chain A Region: 9 - 23 Aligned: 15 Modelled: 15 Confidence: 7.8% Identity: 47% PDB header:penicillin-binding protein/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 1a; PDBTitle: crystal structure of acinetobacter baumannii pbp1a in complex with2 penicillin g Phyre2 PDB 3pbq chain A Region: 9 - 23 Aligned: 15 Modelled: 15 Confidence: 6.2% Identity: 40% PDB header:hydrolase/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of pbp3 complexed with imipenem Phyre2 PDB 2xa6 chain B Region: 36 - 50 Aligned: 15 Modelled: 15 Confidence: 5.9% Identity: 47% PDB header:transcription Chain: B: PDB Molecule:kh domain-containing\,rna-binding\,signal transduction- PDBTitle: structural basis for homodimerization of the src-associated during2 mitosis, 68 kd protein (sam68) qua1 domain Phyre2 PDB 1wrj chain A Region: 6 - 37 Aligned: 31 Modelled: 32 Confidence: 5.6% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:methylated-dna--protein-cysteine PDBTitle: crystal structure of o6-methylguanine methyltransferase2 from sulfolobus tokodaii Phyre2 PDB 4oon chain A Region: 9 - 23 Aligned: 15 Modelled: 15 Confidence: 5.6% Identity: 53% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:penicillin-binding protein 1a; PDBTitle: crystal structure of pbp1a in complex with compound 17 ((4z,8s,11e,2 14s)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-3 dihydro-2h-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-4 triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) Phyre2 PDB 2bg1 chain A domain 1 Region: 9 - 23 Aligned: 15 Modelled: 15 Confidence: 5.2% Identity: 40% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 1 c1z9iA_ 2 c2l1qA_ 3 c3udiA_ 4 c3pbqA_ 5 c2xa6B_ 6 c1wrjA_ 7 c4oonA_ 8 d2bg1a1