1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	R	Q	S	A	V	A	Q	L	R	A	A	A	E	Q	F	A	R	V	H	L	D	A	C	D	R	W	S	V	G	L	S	G	G	P	D	S	L	A	L	T	A	V	A	A	R	L	W	P	T	T	A	L	I	V	D	H	G	L
Secondary structure
SS confidence
Disorder		?	?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	P	G	S	A	T	V	A	E	T	A	R	I	Q	A	I	S	L	G	C	V	D	A	R	V	L	C	V	Q	V	G	A	A	G	G	R	E	A	A	A	R	S	A	R	Y	S	A	L	E	E	H	R	D	G	P	V	L	L	A	H
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	L	D	D	Q	A	E	T	V	L	L	G	L	G	R	G	S	G	A	R	S	I	A	G	M	R	P	Y	D	P	P	W	C	R	P	L	L	G	V	R	R	S	V	T	H	A	A	C	R	E	L	G	L	T	A	W	Q	D	P	H
Secondary structure
SS confidence
Disorder																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	T	D	R	R	F	T	R	T	R	L	R	T	E	V	L	P	L	L	E	D	V	L	G	G	G	V	A	E	A	L	A	R	T	A	T	A	L	R	E	D	T	D	L	I	D	T	I	A	A	Q	A	L	P	G	A	A	V	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	R	G	Q	E	L	S	T	S	A	L	T	A	L	P	D	A	V	R	R	R	V	I	R	G	W	L	L	A	G	G	A	T	G	L	T	D	R	Q	I	R	G	V	D	R	L	V	T	A	W	R	G	Q	G	G	V	A	V	G	S
Secondary structure
SS confidence
Disorder																																	?	?																		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.
Sequence		T	L	R	G	Q	R	L	V	A	G	R	R	D	G	V	L	V	L	R	R	E	P	V
Secondary structure
SS confidence
Disorder																						?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 51%) Beta strand ( 15%)

Rank Aligned region

PDB 3a2k chain B Region: 7 - 322 Aligned: 308 Modelled: 316 Confidence: 100.0% Identity: 31% PDB header:ligase/rna Chain: B: PDB Molecule:trna(ile)-lysidine synthase; PDBTitle: crystal structure of tils complexed with trna Phyre2 PDB 1ni5 chain A Region: 13 - 322 Aligned: 300 Modelled: 309 Confidence: 100.0% Identity: 26% PDB header:cell cycle Chain: A: PDB Molecule:putative cell cycle protein mesj; PDBTitle: structure of the mesj pp-atpase from escherichia coli Phyre2 PDB 2e21 chain A Region: 1 - 321 Aligned: 301 Modelled: 321 Confidence: 100.0% Identity: 27% PDB header:ligase Chain: A: PDB Molecule:trna(ile)-lysidine synthase; PDBTitle: crystal structure of tils in a complex with amppnp from aquifex2 aeolicus. Phyre2 PDB 1ni5 chain A domain 1 Region: 12 - 228 Aligned: 214 Modelled: 215 Confidence: 100.0% Identity: 29% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: PP-loop ATPase Phyre2 PDB 1wy5 chain A domain 1 Region: 2 - 204 Aligned: 200 Modelled: 203 Confidence: 100.0% Identity: 27% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: PP-loop ATPase Phyre2 PDB 3vrh chain A Region: 3 - 220 Aligned: 210 Modelled: 218 Confidence: 100.0% Identity: 20% PDB header:rna binding protein Chain: A: PDB Molecule:putative uncharacterized protein ph0300; PDBTitle: crystal structure of ph0300 Phyre2 PDB 5gha chain C Region: 3 - 218 Aligned: 205 Modelled: 216 Confidence: 100.0% Identity: 21% PDB header:transferase/transport protein Chain: C: PDB Molecule:sulfur transferase ttua; PDBTitle: sulfur transferase ttua in complex with sulfur carrier ttub Phyre2 PDB 5udw chain B Region: 2 - 201 Aligned: 165 Modelled: 175 Confidence: 99.9% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:lactate racemization operon protein lare; PDBTitle: lare, a sulfur transferase involved in synthesis of the cofactor for2 lactate racemase, in complex with nickel Phyre2 PDB 2nz2 chain A Region: 26 - 211 Aligned: 182 Modelled: 186 Confidence: 99.9% Identity: 10% PDB header:ligase Chain: A: PDB Molecule:argininosuccinate synthase; PDBTitle: crystal structure of human argininosuccinate synthase in complex with2 aspartate and citrulline Phyre2 PDB 1vl2 chain C Region: 26 - 189 Aligned: 156 Modelled: 164 Confidence: 99.9% Identity: 13% PDB header:ligase Chain: C: PDB Molecule:argininosuccinate synthase; PDBTitle: crystal structure of argininosuccinate synthase (tm1780) from2 thermotoga maritima at 1.65 a resolution Phyre2 PDB 3k32 chain D Region: 28 - 209 Aligned: 167 Modelled: 179 Confidence: 99.9% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:uncharacterized protein mj0690; PDBTitle: the crystal structure of predicted subunit of trna methyltransferase2 from methanocaldococcus jannaschii dsm Phyre2 PDB 4nzp chain A Region: 26 - 193 Aligned: 161 Modelled: 168 Confidence: 99.9% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:argininosuccinate synthase; PDBTitle: the crystal structure of argininosuccinate synthase from campylobacter2 jejuni subsp. jejuni nctc 11168 Phyre2 PDB 1kh2 chain D Region: 27 - 188 Aligned: 153 Modelled: 159 Confidence: 99.9% Identity: 17% PDB header:ligase Chain: D: PDB Molecule:argininosuccinate synthetase; PDBTitle: crystal structure of thermus thermophilus hb8 argininosuccinate2 synthetase in complex with atp Phyre2 PDB 2c5s chain A domain 1 Region: 22 - 192 Aligned: 159 Modelled: 171 Confidence: 99.9% Identity: 20% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ThiI-like Phyre2 PDB 2dpl chain A Region: 1 - 197 Aligned: 188 Modelled: 189 Confidence: 99.9% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:gmp synthase [glutamine-hydrolyzing] subunit b; PDBTitle: crystal structure of the gmp synthase from pyrococcus horikoshii ot3 Phyre2 PDB 1k97 chain A Region: 20 - 181 Aligned: 156 Modelled: 162 Confidence: 99.9% Identity: 17% PDB header:ligase Chain: A: PDB Molecule:argininosuccinate synthase; PDBTitle: crystal structure of e. coli argininosuccinate synthetase in complex2 with aspartate and citrulline Phyre2 PDB 1vl2 chain A domain 1 Region: 26 - 175 Aligned: 143 Modelled: 150 Confidence: 99.9% Identity: 14% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: N-type ATP pyrophosphatases Phyre2 PDB 1j20 chain A domain 1 Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 99.8% Identity: 20% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: N-type ATP pyrophosphatases Phyre2 PDB 1k92 chain A domain 1 Region: 20 - 180 Aligned: 157 Modelled: 161 Confidence: 99.8% Identity: 15% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: N-type ATP pyrophosphatases Phyre2 PDB 4kr7 chain A Region: 22 - 216 Aligned: 186 Modelled: 195 Confidence: 99.8% Identity: 16% PDB header:transferase/rna Chain: A: PDB Molecule:probable trna sulfurtransferase; PDBTitle: crystal structure of a 4-thiouridine synthetase - rna complex with2 bound atp Phyre2 1 c3a2kB_ 2 c1ni5A_ 3 c2e21A_ 4 d1ni5a1 5 d1wy5a1 6 c3vrhA_ 7 c5ghaC_ 8 c5udwB_ 9 c2nz2A_ 10 c1vl2C_ 11 c3k32D_ 12 c4nzpA_ 13 c1kh2D_ 14 d2c5sa1 15 c2dplA_ 16 c1k97A_ 17 d1vl2a1 18 d1j20a1 19 d1k92a1 20 c4kr7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150