1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	P	T	R	W	R	K	S	T	H	V	V	V	G	A	A	V	L	A	F	V	A	V	V	V	A	A	A	A	L	V	T	T	G	G	H	R	A	G	V	R	A	P	A	P	P	P	R	P	P	T	V	K	A	G	V	V	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	D	T	A	A	T	P	S	A	A	G	V	T	A	A	L	A	V	V	A	A	D	P	D	L	G	K	L	A	G	R	I	T	D	A	L	T	G	Q	E	L	W	Q	R	L	D	D	V	P	L	V	P	A	S	T	N	K	I	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?									?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	A	A	L	L	T	L	D	R	Q	A	R	I	S	T	R	V	V	A	G	G	Q	N	P	Q	G	P	V	V	L	V	G	A	G	D	P	T	L	S	A	A	P	P	G	Q	D	T	W	Y	H	G	A	A	R	I	G	D	L	V
Secondary structure
SS confidence
Disorder																						?																					?	?	?	?		?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	Q	I	R	R	S	G	V	T	P	T	A	V	Q	V	D	A	S	A	F	S	G	P	T	M	A	P	G	W	D	P	A	D	I	D	N	G	D	I	A	P	I	E	A	A	M	I	D	A	G	R	I	Q	P	T	T	V	N	S	R
Secondary structure
SS confidence
Disorder							?																																																?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	S	R	T	P	A	L	D	A	G	R	E	L	A	K	A	L	G	L	D	P	A	A	V	T	I	A	S	A	P	A	G	A	R	Q	L	A	V	V	Q	S	A	P	L	I	Q	R	L	S	Q	M	M	N	A	S	D	N	V	M	A
Secondary structure
SS confidence
Disorder			?					?												?	?	?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	C	I	G	R	E	V	A	V	A	I	N	R	P	Q	S	F	S	G	A	V	D	A	V	T	S	R	L	N	T	A	H	I	D	T	A	G	A	A	L	V	D	S	S	G	L	S	L	D	N	R	L	T	A	R	T	L	D	A	T
Secondary structure
SS confidence
Disorder														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		M	Q	A	A	A	G	P	D	Q	P	A	L	R	P	L	L	D	L	L	P	I	A	G	G	S	G	T	L	G	E	R	F	L	D	A	A	T	D	Q	G	P	A	G	W	L	R	A	K	T	G	S	L	T	A	I	N	S	L	V	G
Secondary structure
SS confidence
Disorder																						?	?	?	?									?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Sequence		V	L	T	D	R	S	G	R	V	L	T	F	A	F	I	S	N	E	A	G	P	N	G	R	N	A	M	D	A	L	A	T	K	L	W	F	C	G	C	T	T
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 34%) Beta strand ( 16%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 1w5d chain A domain 1 Region: 71 - 456 Aligned: 368 Modelled: 386 Confidence: 100.0% Identity: 28% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 2ex2 chain A domain 1 Region: 72 - 456 Aligned: 364 Modelled: 370 Confidence: 100.0% Identity: 30% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 1w79 chain A domain 1 Region: 71 - 456 Aligned: 367 Modelled: 374 Confidence: 100.0% Identity: 31% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 3a3e chain B Region: 83 - 456 Aligned: 353 Modelled: 374 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 (dacb) from2 haemophilus influenzae, complexed with novel beta-lactam (cmv) Phyre2 PDB 3v39 chain A Region: 85 - 456 Aligned: 345 Modelled: 360 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:d-alanyl-d-alanine carboxypeptidase; PDBTitle: bd3459, a predatory peptidoglycan endopeptidase from bdellovibrio2 bacteriovorus Phyre2 PDB 5cer chain I Region: 87 - 456 Aligned: 337 Modelled: 358 Confidence: 100.0% Identity: 17% PDB header:immune system Chain: I: PDB Molecule:bd0816; PDBTitle: bd0816 predatory endopeptidase from bdellovibrio bacteriovorus in2 complex with immunity protein bd3460 Phyre2 PDB 3qhy chain A Region: 73 - 456 Aligned: 245 Modelled: 261 Confidence: 99.9% Identity: 16% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:beta-lactamase; PDBTitle: structural, thermodynamic and kinetic analysis of the picomolar2 binding affinity interaction of the beta-lactamase inhibitor protein-3 ii (blip-ii) with class a beta-lactamases Phyre2 PDB 2v20 chain A Region: 70 - 457 Aligned: 251 Modelled: 267 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase tem; PDBTitle: structure of a tem-1 beta-lactamase insertant allosterically regulated2 by kanamycin and anions. complex with sulfate. Phyre2 PDB 5hw3 chain A Region: 70 - 456 Aligned: 250 Modelled: 267 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of a beta lactamase from burkholderia vietnamiensis Phyre2 PDB 2j7v chain A Region: 64 - 456 Aligned: 256 Modelled: 273 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:tll2115 protein; PDBTitle: structure of pbp-a Phyre2 PDB 5hx9 chain A Region: 72 - 457 Aligned: 245 Modelled: 265 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase from burkholderia vietnamiensis Phyre2 PDB 5e2e chain B Region: 72 - 457 Aligned: 249 Modelled: 265 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase precursor blaa from yersinia2 enterocolitica Phyre2 PDB 6nj1 chain A Region: 70 - 456 Aligned: 248 Modelled: 264 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of class a beta-lactamase from clostridium kluyveri2 dsm 555 Phyre2 PDB 1hzo chain A Region: 72 - 461 Aligned: 253 Modelled: 269 Confidence: 99.9% Identity: 16% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 3cg5 chain A Region: 72 - 456 Aligned: 250 Modelled: 262 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the covalent adduct formed between tb2 b-lactamase and clavulanate Phyre2 PDB 4mxb chain B Region: 72 - 456 Aligned: 246 Modelled: 265 Confidence: 99.9% Identity: 20% PDB header:hydrolase/antibiotic Chain: B: PDB Molecule:bel-1; PDBTitle: crystal structure of extended-spectrum beta-lactamase bel-1 in complex2 with imipenem Phyre2 PDB 2ov5 chain A Region: 74 - 456 Aligned: 246 Modelled: 260 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:carbapenemase; PDBTitle: crystal structure of the kpc-2 carbapenemase Phyre2 PDB 6niq chain B Region: 71 - 457 Aligned: 250 Modelled: 266 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the putative class a beta-lactamase penp from2 rhodopseudomonas palustris Phyre2 PDB 1n9b chain A Region: 68 - 456 Aligned: 252 Modelled: 268 Confidence: 99.9% Identity: 23% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 4eqi chain A Region: 69 - 456 Aligned: 252 Modelled: 267 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:carbapenem-hydrolizing beta-lactamase sfc-1; PDBTitle: crystal structure of serratia fonticola carbapenemase sfc-1 Phyre2 1 d1w5da1 2 d2ex2a1 3 d1w79a1 4 c3a3eB_ 5 c3v39A_ 6 c5cerI_ 7 c3qhyA_ 8 c2v20A_ 9 c5hw3A_ 10 c2j7vA_ 11 c5hx9A_ 12 c5e2eB_ 13 c6nj1A_ 14 d1hzoa_ 15 c3cg5A_ 16 c4mxbB_ 17 c2ov5A_ 18 c6niqB_ 19 d1n9ba_ 20 c4eqiA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219