1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	F	R	I	F	G	F	S	L	L	M	T	V	V	A	L	V	T	G	Y	L	H	G	G	P	T	A	L	F	L	L	A	V	L	A	L	L	E	V	S	L	S	F	D	N	A	I	I	N	A	A	I	L	Q	R	M	S	P
Secondary structure
SS confidence
Disorder		?	?	?																																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	W	Q	R	M	F	L	T	I	G	I	L	I	A	V	F	G	M	R	L	V	F	P	L	A	I	I	W	T	T	A	G	L	D	P	V	R	A	M	E	L	A	L	R	P	P	A	H	G	A	L	E	F	A	D	G	S	P	S	Y
Secondary structure
SS confidence
Disorder																																?															?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	K	L	I	T	A	A	H	P	Q	I	A	A	F	G	G	M	F	L	L	M	L	F	L	D	F	V	V	H	D	R	D	I	K	W	L	K	W	I	E	V	P	F	A	R	I	G	R	L	G	Q	V	P	V	I	V	A	S	V	G
Secondary structure
SS confidence
Disorder									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	V	L	A	G	A	L	L	T	H	S	S	D	Q	R	G	T	V	L	I	A	G	L	L	G	M	V	T	Y	L	V	V	N	G	I	S	R	A	F	R	P	A	G	L	G	E	A	T	P	G	V	Q	A	R	Q	A	A	G	K	A
Secondary structure
SS confidence
Disorder															?																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	C	A	L	F	L	Y	L	E	V	L	D	A	A	F	S	F	D	G	V	T	G	A	F	A	I	T	T	D	P	I	I	I	A	L	G	L	G	V	V	G	A	M	F	V	R	S	I	T	I	Y	L	V	R	Q	D	T	L	D	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	V	Y	L	E	H	G	A	H	W	A	I	G	A	L	A	I	I	L	L	L	S	I	D	H	R	F	A	V	P	E	W	V	T	A	S	V	G	V	V	F	I	G	A	A	F	T	E	S	V	R	R	N	R	L	T	V	R	S	P
Secondary structure
SS confidence
Disorder																																																					?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.
Sequence		T	K	F	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 1bhb chain A Region: 266 - 322 Aligned: 54 Modelled: 57 Confidence: 44.3% Identity: 26% PDB header:photoreceptor Chain: A: PDB Molecule:bacteriorhodopsin; PDBTitle: three-dimensional structure of (1-71) bacterioopsin2 solubilized in methanol-chloroform and sds micelles3 determined by 15n-1h heteronuclear nmr spectroscopy Phyre2 PDB 5frg chain A Region: 55 - 67 Aligned: 13 Modelled: 13 Confidence: 22.8% Identity: 23% PDB header:protein binding Chain: A: PDB Molecule:formin-binding protein 1-like; PDBTitle: the nmr structure of the cdc42-interacting region of toca1 Phyre2 PDB 4ain chain B Region: 31 - 162 Aligned: 95 Modelled: 99 Confidence: 20.7% Identity: 20% PDB header:membrane protein Chain: B: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of betp with asymmetric protomers. Phyre2 PDB 2ke4 chain A Region: 55 - 67 Aligned: 13 Modelled: 13 Confidence: 15.1% Identity: 31% PDB header:membrane protein Chain: A: PDB Molecule:cdc42-interacting protein 4; PDBTitle: the nmr structure of the tc10 and cdc42 interacting domain2 of cip4 Phyre2 PDB 2rlf chain A Region: 268 - 308 Aligned: 31 Modelled: 41 Confidence: 12.2% Identity: 35% PDB header:proton transport Chain: A: PDB Molecule:matrix protein 2; PDBTitle: proton channel m2 from influenza a in complex with2 inhibitor rimantadine Phyre2 PDB 4rib chain A Region: 239 - 264 Aligned: 25 Modelled: 26 Confidence: 11.2% Identity: 24% PDB header:hydrolase/dna Chain: A: PDB Molecule:fanconi-associated nuclease 1; PDBTitle: fan1 nuclease bound to 5' phosphorylated p(dt) single flap dna Phyre2 PDB 5cws chain F Region: 350 - 365 Aligned: 16 Modelled: 16 Confidence: 9.6% Identity: 25% PDB header:protein transport Chain: F: PDB Molecule:nucleoporin nic96; PDBTitle: crystal structure of the intact chaetomium thermophilum nsp1-nup49-2 nup57 channel nucleoporin heterotrimer bound to its nic96 nuclear3 pore complex attachment site Phyre2 PDB 5cws chain L Region: 350 - 365 Aligned: 16 Modelled: 16 Confidence: 9.6% Identity: 25% PDB header:protein transport Chain: L: PDB Molecule:nucleoporin nic96; PDBTitle: crystal structure of the intact chaetomium thermophilum nsp1-nup49-2 nup57 channel nucleoporin heterotrimer bound to its nic96 nuclear3 pore complex attachment site Phyre2 PDB 3pcq chain X Region: 4 - 25 Aligned: 22 Modelled: 22 Confidence: 7.8% Identity: 41% PDB header:photosynthesis Chain: X: PDB Molecule:photosystem i 4.8k protein; PDBTitle: femtosecond x-ray protein nanocrystallography Phyre2 PDB 6hu9 chain G Region: 262 - 282 Aligned: 21 Modelled: 21 Confidence: 5.9% Identity: 14% PDB header:oxidoreductase/electron transport Chain: G: PDB Molecule:cytochrome b-c1 complex subunit 7; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 6hu9 chain S Region: 262 - 282 Aligned: 21 Modelled: 21 Confidence: 5.9% Identity: 14% PDB header:oxidoreductase/electron transport Chain: S: PDB Molecule:cytochrome b-c1 complex subunit 8; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 2odb chain B Region: 55 - 64 Aligned: 10 Modelled: 10 Confidence: 5.7% Identity: 30% PDB header:protein binding Chain: B: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: the crystal structure of human cdc42 in complex with the crib domain2 of human p21-activated kinase 6 (pak6) Phyre2 PDB 4mit chain E Region: 58 - 71 Aligned: 14 Modelled: 14 Confidence: 5.3% Identity: 21% PDB header:signaling protein Chain: E: PDB Molecule:serine/threonine protein kinase pak, putative; PDBTitle: crystal structure of e. histolytica racc bound to the ehpak4 pbd Phyre2 PDB 4mit chain G Region: 58 - 71 Aligned: 14 Modelled: 14 Confidence: 5.3% Identity: 21% PDB header:signaling protein Chain: G: PDB Molecule:serine/threonine protein kinase pak, putative; PDBTitle: crystal structure of e. histolytica racc bound to the ehpak4 pbd Phyre2 PDB 1y82 chain A domain 1 Region: 258 - 277 Aligned: 19 Modelled: 20 Confidence: 5.1% Identity: 32% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 c1bhbA_ 2 c5frgA_ 3 c4ainB_ 4 c2ke4A_ 5 c2rlfA_ 6 c4ribA_ 7 c5cwsF_ 8 c5cwsL_ 9 c3pcqX_ 10 c6hu9g_ 11 c6hu9s_ 12 c2odbB_ 13 c4mitE_ 14 c4mitG_ 15 d1y82a1