1

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10

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20

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30

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40

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50

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60

Sequence

V

E

R

S

I

G

L

E

A

A

A

Q

Q

A

G

H

S

G

S

E

I

T

R

R

H

Y

V

E

R

S

V

T

V

P

D

Y

T

A

A

L

D

E

Y

S

R

P

I

R

A

F

R

P

L

K

S

N

R

P

G

D

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

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Sequence

I

P

T

Secondary structure

SS confidence

Disorder

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 40%) Alpha helix ( 68%) Beta strand ( 0%)

Rank Aligned region

PDB 3uxu chain A Region: 2 - 51 Aligned: 44 Modelled: 50 Confidence: 30.6% Identity: 20% PDB header:recombination Chain: A: PDB Molecule:probable integrase; PDBTitle: the structure of the catalytic domain of the sulfolobus spindle-shaped2 viral integrase reveals an evolutionarily conserved catalytic core3 and supports a mechanism of dna cleavage in trans Phyre2 PDB 3nkh chain B Region: 2 - 27 Aligned: 26 Modelled: 26 Confidence: 26.9% Identity: 27% PDB header:recombination Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of integrase from mrsa strain staphylococcus aureus Phyre2 PDB 1z1b chain A Region: 2 - 26 Aligned: 25 Modelled: 25 Confidence: 14.7% Identity: 20% PDB header:dna binding protein/dna Chain: A: PDB Molecule:integrase; PDBTitle: crystal structure of a lambda integrase dimer bound to a2 coc' core site Phyre2 PDB 6en2 chain A Region: 2 - 27 Aligned: 26 Modelled: 26 Confidence: 14.2% Identity: 23% PDB header:recombination Chain: A: PDB Molecule:int protein; PDBTitle: structure of the tn1549 transposon integrase (aa 82-397, r225k) in2 complex with a circular intermediate dna (ci6b-dna) Phyre2 PDB 2cpg chain A Region: 7 - 45 Aligned: 25 Modelled: 25 Confidence: 10.5% Identity: 36% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 1ea4 chain K Region: 7 - 45 Aligned: 25 Modelled: 25 Confidence: 10.5% Identity: 36% PDB header:gene regulation/dna Chain: K: PDB Molecule:transcriptional repressor copg; PDBTitle: transcriptional repressor copg/22bp dsdna complex Phyre2 PDB 1aih chain A Region: 2 - 27 Aligned: 25 Modelled: 26 Confidence: 10.2% Identity: 24% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 PDB 4xai chain P Region: 40 - 50 Aligned: 11 Modelled: 11 Confidence: 9.1% Identity: 64% PDB header:transcription Chain: P: PDB Molecule:grunge, isoform j; PDBTitle: crystal structure of red flour beetle nr2e1/tlx Phyre2 PDB 3gt2 chain A Region: 6 - 61 Aligned: 52 Modelled: 56 Confidence: 7.5% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the p60 domain from m. avium paratuberculosis2 antigen map1272c Phyre2 PDB 1xrx chain D Region: 12 - 24 Aligned: 13 Modelled: 13 Confidence: 7.3% Identity: 46% PDB header:replication inhibitor Chain: D: PDB Molecule:seqa protein; PDBTitle: crystal structure of a dna-binding protein Phyre2 PDB 1xrx chain A domain 1 Region: 12 - 24 Aligned: 13 Modelled: 13 Confidence: 7.3% Identity: 46% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: SeqA N-terminal domain-like Phyre2 PDB 3bl2 chain A domain 1 Region: 23 - 47 Aligned: 23 Modelled: 25 Confidence: 6.4% Identity: 48% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 4tsk chain A Region: 39 - 60 Aligned: 22 Modelled: 22 Confidence: 5.7% Identity: 36% PDB header:oxidoreductase,isomerase Chain: A: PDB Molecule:ketol-acid reductoisomerase; PDBTitle: ketol-acid reductoisomerase from alicyclobacillus acidocaldarius Phyre2 PDB 5hxy chain E Region: 2 - 27 Aligned: 25 Modelled: 26 Confidence: 5.7% Identity: 20% PDB header:recombination Chain: E: PDB Molecule:tyrosine recombinase xera; PDBTitle: crystal structure of xera recombinase Phyre2 PDB 5c6k chain B Region: 2 - 28 Aligned: 26 Modelled: 27 Confidence: 5.4% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: bacteriophage p2 integrase catalytic domain Phyre2 PDB 2a3v chain A Region: 2 - 34 Aligned: 32 Modelled: 33 Confidence: 5.2% Identity: 25% PDB header:recombination Chain: A: PDB Molecule:site-specific recombinase inti4; PDBTitle: structural basis for broad dna-specificity in integron recombination Phyre2 1 c3uxuA_ 2 c3nkhB_ 3 c1z1bA_ 4 c6en2A_ 5 d2cpga_ 6 c1ea4K_ 7 d1aiha_ 8 c4xaiP_ 9 c3gt2A_ 10 c1xrxD_ 11 d1xrxa1 12 d3bl2a1 13 c4tskA_ 14 c5hxyE_ 15 c5c6kB_ 16 c2a3vA_