Phyre Home Retrieve Phyre Job Id
Emailmdejesus@rockefeller.edu
DescriptionRVBD3645_(-)_4082986_4084635
DateFri Aug 9 18:20:33 BST 2019
Unique Job ID275a4a82e2a98f1d
SequenceMDAEAFVGFR ... Download FASTA
Job Typenormal
Job Expiry

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:66.686 Y:45.640 Z:46.840
Model (left) based on template c6fhtB_
Top template information
PDB header:lyase
Chain: B: PDB Molecule:bacteriophytochrome,adenylate cyclase;
PDBTitle: crystal structure of an artificial phytochrome regulated2 adenylate/guanylate cyclase in its dark adapted pr form
Confidence and coverage
Confidence:100.0% Coverage: 42%
233 residues ( 42% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
421 residues ( 77%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
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Sequence analysis 

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Secondary structure and disorder prediction [Show] 

Domain analysis [Show] 

Detailed template information [Hide] 

 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c6fhtB_
100.0 30
PDB header:lyase
Chain: B: PDB Molecule:bacteriophytochrome,adenylate cyclase;
PDBTitle: crystal structure of an artificial phytochrome regulated2 adenylate/guanylate cyclase in its dark adapted pr form
2c4yusA_
100.0 27
PDB header:lyase
Chain: A: PDB Molecule:family 3 adenylate cyclase;
PDBTitle: crystal structure of photoactivated adenylyl cyclase of a2 cyanobacteriaoscillatoria acuminata in hexagonal form
3c5nbyA_
100.0 24
PDB header:lyase
Chain: A: PDB Molecule:beta subunit of photoactivated adenylyl cyclase;
PDBTitle: structure of a bacterial light-regulated adenylyl cylcase
4c6r4oA_
100.0 18
PDB header:membrane protein
Chain: A: PDB Molecule:adenylate cyclase 9;
PDBTitle: structure of a truncated adenylyl cyclase bound to mant-gtp, forskolin2 and an activated stimulatory galphas protein
5c4cllA_
100.0 25
PDB header:lyase
Chain: A: PDB Molecule:adenylate cyclase type 10;
PDBTitle: crystal structure of human soluble adenylyl cyclase in complex with2 bicarbonate
6c5o5kC_
100.0 26
PDB header:membrane protein
Chain: C: PDB Molecule:adenylate cyclase;
PDBTitle: x-ray structure of a bacterial adenylyl cyclase soluble domain
7c6r4pA_
100.0 20
PDB header:membrane protein
Chain: A: PDB Molecule:adenylate cyclase 9;
PDBTitle: structure of a soluble domain of adenylyl cyclase bound to an2 activated stimulatory g protein
8c1y10C_
100.0 24
PDB header:lyase
Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302;
PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state
9c2w01C_
100.0 29
PDB header:lyase
Chain: C: PDB Molecule:adenylate cyclase;
PDBTitle: crystal structure of the guanylyl cyclase cya2
10c1wc6B_
100.0 33
PDB header:lyase
Chain: B: PDB Molecule:adenylate cyclase;
PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate
11d1wc1a_
100.0 33
Fold:Ferredoxin-like
Superfamily:Nucleotide cyclase
Family:Adenylyl and guanylyl cyclase catalytic domain
12c1cjkA_
100.0 19
PDB header:lyase/lyase/signaling protein
Chain: A: PDB Molecule:adenylate cyclase, type v;
PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn
13c3r5gB_
100.0 26
PDB header:lyase
Chain: B: PDB Molecule:cyab;
PDBTitle: crystal structure of the adenylyl cyclase cyab from p. aeruginosa
14d1azsa_
100.0 19
Fold:Ferredoxin-like
Superfamily:Nucleotide cyclase
Family:Adenylyl and guanylyl cyclase catalytic domain
15d1fx2a_
100.0 20
Fold:Ferredoxin-like
Superfamily:Nucleotide cyclase
Family:Adenylyl and guanylyl cyclase catalytic domain
16c3uvjC_
100.0 20
PDB header:lyase
Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3;
PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1.
17d1fx4a_
100.0 20
Fold:Ferredoxin-like
Superfamily:Nucleotide cyclase
Family:Adenylyl and guanylyl cyclase catalytic domain
18c3et6A_
100.0 24
PDB header:lyase
Chain: A: PDB Molecule:soluble guanylyl cyclase beta;
PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase
19c3mr7B_
100.0 24
PDB header:hydrolase
Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold
PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi
20c2wz1B_
100.0 22
PDB header:lyase
Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1;
PDBTitle: structure of the catalytic domain of human soluble guanylate cyclase 12 beta 3.
21c1ybuA_
not modelled 100.0 28
PDB header:hydrolase
Chain: A: PDB Molecule:lipj;
PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog.
22d1azsb_
not modelled 100.0 19
Fold:Ferredoxin-like
Superfamily:Nucleotide cyclase
Family:Adenylyl and guanylyl cyclase catalytic domain
23c1yk9A_
not modelled 100.0 25
PDB header:lyase
Chain: A: PDB Molecule:adenylate cyclase;
PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c
24c4wp3E_
not modelled 100.0 26
PDB header:lyase
Chain: E: PDB Molecule:ma1120;
PDBTitle: crystal structure of adenylyl cyclase from mycobacterium avium ma11202 wild type
25c6aoaA_
not modelled 100.0 24
PDB header:lyase
Chain: A: PDB Molecule:bacterio-rhodopsin/guanylyl cyclase 1 fusion protein;
PDBTitle: monomeric crystal structure of the e497/c566d double mutant of the2 guanylyl cyclase domain of the rhogc fusion protein from the aquatic3 fungus blastocladiella emersonii
26c5jefA_
not modelled 99.2 18
PDB header:transferase
Chain: A: PDB Molecule:nitrate/nitrite sensor protein narq;
PDBTitle: fragment of nitrate/nitrite sensor histidine kinase narq (wt) in2 asymmetric holo state
27c4gn0D_
not modelled 99.1 18
PDB header:signaling protein
Chain: D: PDB Molecule:hamp domain of af1503;
PDBTitle: de novo phasing of a hamp-complex using an improved arcimboldo method
28c3lnrA_
not modelled 98.6 17
PDB header:signaling protein
Chain: A: PDB Molecule:aerotaxis transducer aer2;
PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2
29c3zx6A_
not modelled 98.4 23
PDB header:signaling
Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i;
PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant
30d2asxa1
not modelled 98.4 24
Fold:HAMP domain-like
Superfamily:HAMP domain-like
Family:HAMP domain
31c3zrwB_
not modelled 98.1 24
PDB header:signaling protein
Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz;
PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant
32c4i5sA_
not modelled 98.0 21
PDB header:transferase
Chain: A: PDB Molecule:putative histidine kinase covs; vick-like protein;
PDBTitle: structure and function of sensor histidine kinase
33c4ctiA_
not modelled 97.4 23
PDB header:signaling protein
Chain: A: PDB Molecule:osmolarity sensor protein envz, af1503;
PDBTitle: escherichia coli envz histidine kinase catalytic part fused to2 archaeoglobus fulgidus af1503 hamp domain
34c4biuB_
not modelled 97.3 26
PDB header:transferase
Chain: B: PDB Molecule:sensor protein cpxa;
PDBTitle: crystal structure of cpxahdc (orthorhombic form 1)
35c2qv6D_
not modelled 96.8 14
PDB header:hydrolase
Chain: D: PDB Molecule:gtp cyclohydrolase iii;
PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions
36c2rm8A_
not modelled 96.1 21
PDB header:signaling protein
Chain: A: PDB Molecule:sensory rhodopsin ii transducer;
PDBTitle: the solution structure of phototactic transducer protein2 htrii linker region from natronomonas pharaonis
37c5llxB_
not modelled 95.9 19
PDB header:transferase
Chain: B: PDB Molecule:diguanylate cyclase (ggdef) domain-containing protein;
PDBTitle: bacteriophytochrome activated diguanylyl cyclase from idiomarina2 species a28l with gtp bound
38c1w25B_
not modelled 95.6 16
PDB header:signaling protein
Chain: B: PDB Molecule:stalked-cell differentiation controlling protein;
PDBTitle: response regulator pled in complex with c-digmp
39c4wxoA_
not modelled 95.0 14
PDB header:transferase
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: sadc (300-487) from pseudomonas aeruginosa pao1
40c4zmuD_
not modelled 94.9 15
PDB header:lyase
Chain: D: PDB Molecule:diguanylate cyclase;
PDBTitle: dcsbis, a diguanylate cyclase from pseudomonas aeruginosa
41c3i5aA_
not modelled 94.9 14
PDB header:signaling protein
Chain: A: PDB Molecule:response regulator/ggdef domain protein;
PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae
42c3mtkA_
not modelled 94.5 16
PDB header:transferase
Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase;
PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c
43c3ezuA_
not modelled 94.1 18
PDB header:signaling protein
Chain: A: PDB Molecule:ggdef domain protein;
PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution
44c6d9mA_
not modelled 94.1 18
PDB header:hydrolase
Chain: A: PDB Molecule:fusion protein of endolysin,response receiver sensor
PDBTitle: t4-lysozyme fusion to geobacter ggdef
45c3breA_
not modelled 92.4 14
PDB header:signaling protein
Chain: A: PDB Molecule:probable two-component response regulator;
PDBTitle: crystal structure of p.aeruginosa pa3702
46c3ignA_
not modelled 92.2 14
PDB header:transferase
Chain: A: PDB Molecule:diguanylate cyclase;
PDBTitle: crystal structure of the ggdef domain from marinobacter aquaeolei2 diguanylate cyclase complexed with c-di-gmp - northeast structural3 genomics consortium target mqr89a
47c3i5cA_
not modelled 91.8 18
PDB header:signaling protein
Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response
PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa
48c3hvwA_
not modelled 91.7 13
PDB header:lyase
Chain: A: PDB Molecule:diguanylate-cyclase (dgc);
PDBTitle: crystal structure of the ggdef domain of the pa2567 protein from2 pseudomonas aeruginosa, northeast structural genomics consortium3 target par365c
49c3ungC_
not modelled 91.4 23
PDB header:unknown function
Chain: C: PDB Molecule:cmr2dhd;
PDBTitle: structure of the cmr2 subunit of the crispr rna silencing complex
50c5euhA_
not modelled 89.0 18
PDB header:membrane protein
Chain: A: PDB Molecule:putative ggdef domain membrane protein;
PDBTitle: crystal structure of the c-di-gmp-bound ggdef domain of p. fluorescens2 gcbc
51c3i5bA_
not modelled 88.5 17
PDB header:signaling protein
Chain: A: PDB Molecule:wspr response regulator;
PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa
52c4h54B_
not modelled 88.0 12
PDB header:transferase
Chain: B: PDB Molecule:diguanylate cyclase ydeh;
PDBTitle: crystal structure of the diguanylate cyclase dgcz
53c4dmzB_
not modelled 87.7 9
PDB header:nucleotide-binding protein
Chain: B: PDB Molecule:putative uncharacterized protein peld;
PDBTitle: peld 156-455 from pseudomonas aeruginosa pa14, apo form
54c4ymeA_
not modelled 86.8 20
PDB header:lyase
Chain: A: PDB Molecule:sensory box/ggdef family protein;
PDBTitle: crystal structure of a sensory box/ggdef family protein (cc_0091) from2 caulobacter crescentus cb15 at 1.40 a resolution (psi community3 target, shapiro)
55c4zvhB_
not modelled 86.2 13
PDB header:signaling protein
Chain: B: PDB Molecule:diguanylate cyclase dosc;
PDBTitle: crystal structure of ggdef domain of the e. coli dosc - form iv
56d1w25a3
not modelled 85.6 16
Fold:Ferredoxin-like
Superfamily:Nucleotide cyclase
Family:GGDEF domain
57c5m3cB_
not modelled 84.7 15
PDB header:hydrolase
Chain: B: PDB Molecule:diguanylate cyclase;
PDBTitle: structure of the hybrid domain (ggdef-eal) of pa0575 from pseudomonas2 aeruginosa pao1 at 2.8 ang. with gtp and ca2+ bound to the active3 site of the ggdef domain
58c3hvaA_
not modelled 83.4 21
PDB header:transferase
Chain: A: PDB Molecule:protein fimx;
PDBTitle: crystal structure of fimx ggdef domain from pseudomonas aeruginosa
59c3hlsE_
not modelled 81.9 22
PDB header:signaling protein
Chain: E: PDB Molecule:guanylate cyclase soluble subunit beta-1;
PDBTitle: crystal structure of the signaling helix coiled-coil doimain2 of the beta-1 subunit of the soluble guanylyl cyclase
60c4w8yA_
not modelled 81.8 23
PDB header:rna binding protein
Chain: A: PDB Molecule:crispr system cmr subunit cmr2;
PDBTitle: structure of full length cmr2 from pyrococcus furiosus (manganese2 bound form)
61c3pjwA_
not modelled 81.6 14
PDB header:lyase
Chain: A: PDB Molecule:cyclic dimeric gmp binding protein;
PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23
62c5xgdA_
not modelled 81.5 16
PDB header:transcription
Chain: A: PDB Molecule:uncharacterized protein pa0861;
PDBTitle: crystal structure of the pas-ggdef-eal domain of pa0861 from2 pseudomonas aeruginosa in complex with gtp
63c3qyyB_
not modelled 80.8 11
PDB header:signaling protein/inhibitor
Chain: B: PDB Molecule:response regulator;
PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp
64c4urgB_
not modelled 80.2 22
PDB header:lyase
Chain: B: PDB Molecule:diguanylate cyclase;
PDBTitle: crystal structure of ggdef domain from t.maritima (active-like dimer)
65c3iclA_
not modelled 79.9 18
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:eal/ggdef domain protein;
PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium target mcr174c
66c6eibC_
not modelled 79.3 13
PDB header:transferase
Chain: C: PDB Molecule:sensory box/ggdef family protein;
PDBTitle: structure of the active ggeef domain of a diguanylate cyclase from2 vibrio cholerae.
67c4iobA_
not modelled 77.3 16
PDB header:lyase
Chain: A: PDB Molecule:diguanylate cyclase tpbb;
PDBTitle: crystal structure of the ggdef domain of pa1120 (yfin or tpbb) from2 pseudomonas aeruginosa at 2.7 ang.
68c3tvkA_
not modelled 71.6 16
PDB header:transferase
Chain: A: PDB Molecule:diguanylate cyclase dgcz;
PDBTitle: diguanylate cyclase domain of dgcz
69c4zmmB_
not modelled 54.9 14
PDB header:transferase
Chain: B: PDB Molecule:diguanylate cyclase;
PDBTitle: ggdef domain of dcsbis complexed with c-di-gmp
70c4euvA_
not modelled 48.4 11
PDB header:signaling protein
Chain: A: PDB Molecule:peld;
PDBTitle: crystal structure of peld 158-ct from pseudomonas aeruginosa pao1, in2 complex with c-di-gmp, form 1
71c4b03D_
not modelled 46.9 20
PDB header:virus
Chain: D: PDB Molecule:dengue virus 1 prm protein;
PDBTitle: 6a electron cryomicroscopy structure of immature dengue virus serotype2 1
72c6ifnA_
not modelled 34.3 22
PDB header:rna binding protein
Chain: A: PDB Molecule:type iii-a crispr-associated protein csm1;
PDBTitle: crystal structure of type iii-a crispr csm complex
73c5buzC_
not modelled 30.8 29
PDB header:transport protein
Chain: C: PDB Molecule:snap receptor-like protein;
PDBTitle: crystal structure of a complex between the snare vam3 and the hops2 vps33-vps16 subcomplex from chaetomium thermophilum
74c4rnhA_
not modelled 30.7 19
PDB header:transferase, hydrolase
Chain: A: PDB Molecule:motility regulator;
PDBTitle: pamora tandem diguanylate cyclase - phosphodiesterase, c-di-gmp2 complex
75c3j2pD_
not modelled 29.0 17
PDB header:viral protein
Chain: D: PDB Molecule:small envelope protein m;
PDBTitle: cryoem structure of dengue virus envelope protein heterotetramer
76c2x5eA_
not modelled 25.0 15
PDB header:unknown function
Chain: A: PDB Molecule:upf0271 protein pa4511;
PDBTitle: crystal structure of the hypothetical protein pa4511 from2 pseudomonas aeruginosa
77c6abeC_
not modelled 23.1 26
PDB header:viral protein/rna
Chain: C: PDB Molecule:polymerase pb2;
PDBTitle: structure of influenza d virus polymerase bound to vrna promoter in2 mode b conformation (class b2)
78c5wsnD_
not modelled 22.7 23
PDB header:virus
Chain: D: PDB Molecule:m protein;
PDBTitle: structure of japanese encephalitis virus
79c5ireD_
not modelled 21.8 20
PDB header:virus
Chain: D: PDB Molecule:m protein;
PDBTitle: the cryo-em structure of zika virus
80c5azdA_
not modelled 20.9 18
PDB header:transport protein
Chain: A: PDB Molecule:bacteriorhodopsin;
PDBTitle: crystal structure of thermophilic rhodopsin.
81c4biyD_
not modelled 20.2 15
PDB header:transferase
Chain: D: PDB Molecule:sensor protein cpxa;
PDBTitle: crystal structure of cpxahdc (monoclinic form 2)
82c6abfC_
not modelled 18.2 26
PDB header:viral protein/rna
Chain: C: PDB Molecule:polymerase pb2;
PDBTitle: structure of influenza d virus polymerase bound to vrna promoter in2 mode b conformation (class b1)
83c2d9dA_
not modelled 17.2 25
PDB header:chaperone
Chain: A: PDB Molecule:bag family molecular chaperone regulator 5;
PDBTitle: solution structure of the bag domain (275-350) of bag-family2 molecular chaperone regulator-5
84d1tlha_
not modelled 16.8 36
Fold:Anti-sigma factor AsiA
Superfamily:Anti-sigma factor AsiA
Family:Anti-sigma factor AsiA
85c1p58E_
not modelled 16.1 14
PDB header:virus
Chain: E: PDB Molecule:envelope protein m;
PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction
86c3dcaC_
not modelled 15.4 26
PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:rpa0582;
PDBTitle: crystal structure of the rpa0582- protein of unknown2 function from rhodopseudomonas palustris- a structural3 genomics target
87d1veha_
not modelled 15.4 31
Fold:Alpha-lytic protease prodomain-like
Superfamily:Fe-S cluster assembly (FSCA) domain-like
Family:NifU C-terminal domain-like
88c5b2nA_
not modelled 14.7 14
PDB header:transport protein
Chain: A: PDB Molecule:chloride pumping rhodopsin;
PDBTitle: crystal structure of the light-driven chloride ion-pumping rhodopsin,2 clp, from nonlabens marinus
89c2w6bA_
not modelled 14.3 21
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7;
PDBTitle: crystal structure of the trimeric beta-pix coiled-coil2 domain
90d1q8ka2
not modelled 14.1 16
Fold:Ferredoxin-like
Superfamily:eIF-2-alpha, C-terminal domain
Family:eIF-2-alpha, C-terminal domain
91d1u7la_
not modelled 13.5 30
Fold:Vacuolar ATP synthase subunit C
Superfamily:Vacuolar ATP synthase subunit C
Family:Vacuolar ATP synthase subunit C
92d1zbxb1
not modelled 12.1 7
Fold:ORC1-binding domain
Superfamily:ORC1-binding domain
Family:ORC1-binding domain
93c4wrtC_
not modelled 11.9 26
PDB header:transferase/rna
Chain: C: PDB Molecule:pb2;
PDBTitle: crystal structure of influenza b polymerase with bound vrna promoter2 (form flub2)
94c6c5wA_
not modelled 11.5 9
PDB header:membrane protein
Chain: A: PDB Molecule:calcium uniporter;
PDBTitle: crystal structure of the mitochondrial calcium uniporter
95d2dfaa1
not modelled 11.3 22
Fold:7-stranded beta/alpha barrel
Superfamily:Glycoside hydrolase/deacetylase
Family:LamB/YcsF-like
96c1z5sD_
not modelled 10.8 30
PDB header:ligase
Chain: D: PDB Molecule:ran-binding protein 2;
PDBTitle: crystal structure of a complex between ubc9, sumo-1,2 rangap1 and nup358/ranbp2
97d1f6ga_
not modelled 10.7 15
Fold:Voltage-gated potassium channels
Superfamily:Voltage-gated potassium channels
Family:Voltage-gated potassium channels
98d1v6ta_
not modelled 10.6 14
Fold:7-stranded beta/alpha barrel
Superfamily:Glycoside hydrolase/deacetylase
Family:LamB/YcsF-like
99c2vg2C_
not modelled 10.5 14
PDB header:transferase
Chain: C: PDB Molecule:undecaprenyl pyrophosphate synthetase;
PDBTitle: rv2361 with ipp

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Transmembrane helix prediction 

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