1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	A	V	A	M	V	A	V	L	L	C	V	T	G	A	G	A	Y	L	G	S	A	V	V	A	R	H	R	A	Q	A	A	A	D	L	A	S	L	A	A	A	A	R	L	P	S	G	L	A	A	A	C	A	R	A	T	L	V	A
Secondary structure
SS confidence
Disorder		?																																												?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.
Sequence		R	A	M	R	V	E	H	A	Q	C	R	V	V	D	L	D	V	V	V	T	V	E	V	A	V	A	F	A	G	V	A	T	A	T	A	R	A	G	P	A	K	V	P	T	T	P	G
Secondary structure
SS confidence
Disorder			?	?	?	?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 53%) Beta strand ( 21%) TM helix ( 15%) (View membrane topology prediction)

Rank Aligned region

PDB 6hr8 chain C Region: 41 - 88 Aligned: 42 Modelled: 48 Confidence: 48.8% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:hmg-coa reductase; PDBTitle: hmg-coa reductase from methanothermococcus thermolithotrophicus in2 complex with nadph at 2.9 a resolution Phyre2 PDB 1hw8 chain C domain 2 Region: 41 - 88 Aligned: 45 Modelled: 48 Confidence: 40.0% Identity: 11% Fold: Substrate-binding domain of HMG-CoA reductase Superfamily: Substrate-binding domain of HMG-CoA reductase Family: Substrate-binding domain of HMG-CoA reductase Phyre2 PDB 1qax chain A Region: 41 - 88 Aligned: 48 Modelled: 48 Confidence: 34.2% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:protein (3-hydroxy-3-methylglutaryl-coenzyme a reductase); PDBTitle: ternary complex of pseudomonas mevalonii hmg-coa reductase with hmg-2 coa and nad+ Phyre2 PDB 3cd0 chain B Region: 41 - 88 Aligned: 45 Modelled: 48 Confidence: 34.1% Identity: 11% PDB header:oxidoreductase Chain: B: PDB Molecule:3-hydroxy-3-methylglutaryl-coenzyme a reductase; PDBTitle: thermodynamic and structure guided design of statin hmg-coa reductase2 inhibitors Phyre2 PDB 1dqa chain A domain 4 Region: 41 - 88 Aligned: 45 Modelled: 48 Confidence: 26.7% Identity: 11% Fold: Substrate-binding domain of HMG-CoA reductase Superfamily: Substrate-binding domain of HMG-CoA reductase Family: Substrate-binding domain of HMG-CoA reductase Phyre2 PDB 1r31 chain A domain 2 Region: 41 - 90 Aligned: 50 Modelled: 50 Confidence: 25.1% Identity: 18% Fold: Substrate-binding domain of HMG-CoA reductase Superfamily: Substrate-binding domain of HMG-CoA reductase Family: Substrate-binding domain of HMG-CoA reductase Phyre2 PDB 3qau chain A Region: 41 - 90 Aligned: 50 Modelled: 50 Confidence: 19.1% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:3-hydroxy-3-methylglutaryl-coenzyme a reductase; PDBTitle: 3-hydroxy-3-methylglutaryl-coenzyme a reductase from streptococcus2 pneumoniae Phyre2 PDB 1hwj chain B Region: 41 - 88 Aligned: 45 Modelled: 48 Confidence: 18.3% Identity: 11% PDB header:oxidoreductase Chain: B: PDB Molecule:hmg-coa reductase; PDBTitle: complex of the catalytic portion of human hmg-coa reductase2 with cerivastatin Phyre2 PDB 2djm chain A Region: 61 - 94 Aligned: 34 Modelled: 34 Confidence: 16.6% Identity: 12% PDB header:sugar binding protein Chain: A: PDB Molecule:glucoamylase a; PDBTitle: solution structure of n-terminal starch-binding domain of2 glucoamylase from rhizopus oryzae Phyre2 PDB 1hw8 chain A domain 2 Region: 41 - 88 Aligned: 45 Modelled: 48 Confidence: 11.2% Identity: 11% Fold: Substrate-binding domain of HMG-CoA reductase Superfamily: Substrate-binding domain of HMG-CoA reductase Family: Substrate-binding domain of HMG-CoA reductase Phyre2 PDB 1r7i chain B Region: 10 - 90 Aligned: 80 Modelled: 81 Confidence: 10.5% Identity: 10% PDB header:oxidoreductase Chain: B: PDB Molecule:3-hydroxy-3-methylglutaryl-coenzyme a reductase; PDBTitle: hmg-coa reductase from p. mevalonii, native structure at 2.2 angstroms2 resolution. Phyre2 PDB 2ifr chain A domain 1 Region: 63 - 80 Aligned: 18 Modelled: 18 Confidence: 7.9% Identity: 17% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Peptidase A4 Phyre2 PDB 4kp4 chain B Region: 54 - 86 Aligned: 33 Modelled: 33 Confidence: 7.7% Identity: 6% PDB header:transferase/signaling protein Chain: B: PDB Molecule:osmolarity sensor protein envz, histidine kinase; PDBTitle: deciphering cis-trans directionality and visualizing2 autophosphorylation in histidine kinases. Phyre2 1 c6hr8C_ 2 d1hw8c2 3 c1qaxA_ 4 c3cd0B_ 5 d1dqaa4 6 d1r31a2 7 c3qauA_ 8 c1hwjB_ 9 c2djmA_ 10 d1hw8a2 11 c1r7iB_ 12 d2ifra1 13 c4kp4B_