1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	E	H	T	G	F	W	L	D	A	W	R	G	L	R	R	R	P	K	F	V	I	A	A	A	L	I	L	L	I	L	V	V	A	A	F	P	S	L	F	T	A	A	D	P	T	Y	A	D	P	S	Q	S	M	L	A	P	S	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	H	W	F	G	T	D	L	Q	G	H	D	I	Y	S	R	T	V	Y	G	A	R	A	S	V	T	V	G	L	G	A	T	L	A	V	F	V	V	G	G	A	L	G	A	L	A	G	F	Y	G	S	W	I	D	A	V	V	S	R	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	D	V	F	L	G	L	P	L	L	L	A	A	I	V	L	M	Q	V	M	H	H	R	T	V	W	T	V	I	A	I	L	A	L	F	G	W	P	Q	V	A	R	I	A	R	G	A	V	L	E	V	R	A	S	D	Y	V	L	A	A
Secondary structure
SS confidence
Disorder																						?																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	A	L	G	L	N	R	F	Q	I	L	L	R	H	A	L	P	N	A	V	G	P	V	I	A	V	A	T	V	A	L	G	I	F	I	V	T	E	A	T	L	S	Y	L	G	V	G	L	P	T	S	V	V	S	W	G	G	D	I	N
Secondary structure
SS confidence
Disorder								?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.
Sequence		V	A	Q	T	R	L	R	S	G	S	P	I	L	F	Y	P	A	G	A	L	A	I	T	V	L	A	F	M	M	M	G	D	A	L	R	D	A	L	D	P	A	S	R	A	W	R	A
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 81%) Beta strand ( 0%) TM helix ( 49%) (View membrane topology prediction)

Rank Aligned region

PDB 4tqv chain I Region: 9 - 280 Aligned: 260 Modelled: 272 Confidence: 99.9% Identity: 12% PDB header:transport protein Chain: I: PDB Molecule:algm1; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 4ymu chain C Region: 66 - 278 Aligned: 207 Modelled: 213 Confidence: 99.9% Identity: 14% PDB header:protein binding/transport protein Chain: C: PDB Molecule:abc-type amino acid transport system, permease component; PDBTitle: crystal structure of an amino acid abc transporter complex with2 arginines and atps Phyre2 PDB 2onk chain C domain 1 Region: 14 - 274 Aligned: 237 Modelled: 243 Confidence: 99.9% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 14 - 274 Aligned: 237 Modelled: 243 Confidence: 99.9% Identity: 16% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 3fh6 chain F Region: 13 - 281 Aligned: 266 Modelled: 269 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 3d31 chain C domain 1 Region: 21 - 270 Aligned: 227 Modelled: 233 Confidence: 99.9% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain D Region: 21 - 270 Aligned: 227 Modelled: 233 Confidence: 99.9% Identity: 16% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease protein; PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 4tqv chain J Region: 13 - 272 Aligned: 259 Modelled: 260 Confidence: 99.9% Identity: 10% PDB header:transport protein Chain: J: PDB Molecule:algm2; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 2r6g chain F domain 2 Region: 67 - 270 Aligned: 204 Modelled: 204 Confidence: 99.9% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3dhw chain A domain 1 Region: 77 - 272 Aligned: 189 Modelled: 194 Confidence: 99.9% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain G domain 1 Region: 16 - 272 Aligned: 255 Modelled: 257 Confidence: 99.9% Identity: 13% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F Region: 58 - 270 Aligned: 213 Modelled: 213 Confidence: 99.9% Identity: 14% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 5kbu chain A Region: 83 - 275 Aligned: 151 Modelled: 161 Confidence: 95.8% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:glutamate receptor 2,voltage-dependent calcium channel PDBTitle: cryo-em structure of glua2-2xstz complex at 7.8 angstrom resolution Phyre2 PDB 2nd4 chain A Region: 164 - 184 Aligned: 21 Modelled: 21 Confidence: 38.0% Identity: 38% PDB header:hydrolase receptor Chain: A: PDB Molecule:amylase-binding protein abpa; PDBTitle: a distinct sortase srtb anchors and processes a streptococcal adhesin2 abpa with a novel structural property Phyre2 PDB 2voy chain B Region: 2 - 36 Aligned: 34 Modelled: 35 Confidence: 26.8% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium atpase 1; PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 1p7b chain A domain 2 Region: 2 - 106 Aligned: 105 Modelled: 105 Confidence: 21.9% Identity: 15% Fold: Voltage-gated potassium channels Superfamily: Voltage-gated potassium channels Family: Voltage-gated potassium channels Phyre2 PDB 2qks chain A Region: 4 - 106 Aligned: 103 Modelled: 103 Confidence: 18.0% Identity: 13% PDB header:metal transport Chain: A: PDB Molecule:kir3.1-prokaryotic kir channel chimera; PDBTitle: crystal structure of a kir3.1-prokaryotic kir channel chimera Phyre2 PDB 3lge chain G Region: 2 - 10 Aligned: 9 Modelled: 9 Confidence: 14.8% Identity: 11% PDB header:lyase/protein binding Chain: G: PDB Molecule:sorting nexin-9; PDBTitle: crystal structure of rabbit muscle aldolase-snx9 lc4 complex Phyre2 PDB 3lge chain F Region: 2 - 10 Aligned: 9 Modelled: 9 Confidence: 14.8% Identity: 11% PDB header:lyase/protein binding Chain: F: PDB Molecule:sorting nexin-9; PDBTitle: crystal structure of rabbit muscle aldolase-snx9 lc4 complex Phyre2 PDB 2jwa chain A Region: 83 - 115 Aligned: 33 Modelled: 33 Confidence: 14.3% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 1 c4tqvI_ 2 c4ymuC_ 3 d2onkc1 4 c2onkC_ 5 c3fh6F_ 6 d3d31c1 7 c3d31D_ 8 c4tqvJ_ 9 d2r6gf2 10 d3dhwa1 11 d2r6gg1 12 c2r6gF_ 13 c5kbuA_ 14 c2nd4A_ 15 c2voyB_ 16 d1p7ba2 17 c2qksA_ 18 c3lgeG_ 19 c3lgeF_ 20 c2jwaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37