1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	G	G	T	P	L	Q	A	G	A	T	P	T	G	S	R	G	T	V	A	L	R	P	D	A	G	P	S	W	L	R	P	L	V	D	N	V	G	Q	I	P	D	A	Y	R	R	R	L	P	A	D	V	L	A	M	V	T	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?	?	?		?	?				?		?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	A	V	S	A	M	T	S	S	R	R	D	H	R	E	A	A	V	L	V	L	F	S	G	P	E	A	G	P	G	D	G	G	V	P	D	D	A	D	L	L	L	T	V	R	A	S	T	L	R	H	H	A	G	Q	A	A	F	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?	?		?																?		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	V	V	D	P	A	D	D	G	P	V	A	T	A	L	R	E	A	N	E	E	T	G	I	D	P	S	R	L	H	P	L	A	T	M	E	R	T	F	I	A	P	S	R	F	H	V	V	P	V	L	A	Y	S	P	D	P	G	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	A	V	V	N	E	A	E	T	A	I	V	A	R	V	P	V	R	A	F	I	N	P	A	N	R	L	M	V	Y	R	R	P	H	T	R	R	W	A	G	P	A	F	L	L	N	Q	M	L	V	W	G	F	T	G	Q	V	I	S	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.
Sequence		V	L	D	V	A	G	W	A	Q	P	W	D	T	G	D	I	R	E	L	D	A	A	M	V	L	I	D	D	E	S	D	P	R
Secondary structure
SS confidence
Disorder														?	?	?	?										?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 28%) Beta strand ( 21%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 5t3p chain B Region: 75 - 268 Aligned: 182 Modelled: 194 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:peroxisomal coenzyme a diphosphatase nudt7; PDBTitle: crystal structure of human peroxisomal coenzyme a diphosphatase nudt7 Phyre2 PDB 1nqz chain A Region: 75 - 243 Aligned: 151 Modelled: 169 Confidence: 100.0% Identity: 32% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5lf8 chain A Region: 89 - 245 Aligned: 156 Modelled: 157 Confidence: 99.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:nucleoside diphosphate-linked moiety x motif 17; PDBTitle: human nucleoside diphosphate-linked moiety x motif 17 (nudt17) Phyre2 PDB 3gz8 chain C Region: 72 - 202 Aligned: 119 Modelled: 131 Confidence: 99.7% Identity: 21% PDB header:dna binding protein Chain: C: PDB Molecule:mutt/nudix family protein; PDBTitle: cocrystal structure of nudix domain of shewanella oneidensis nrtr2 complexed with adp ribose Phyre2 PDB 3h95 chain A Region: 87 - 205 Aligned: 108 Modelled: 111 Confidence: 99.7% Identity: 19% PDB header:gene regulation Chain: A: PDB Molecule:nucleoside diphosphate-linked moiety x motif 6; PDBTitle: crystal structure of the nudix domain of nudt6 Phyre2 PDB 3qsj chain A Region: 70 - 202 Aligned: 124 Modelled: 130 Confidence: 99.6% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from alicyclobacillus2 acidocaldarius Phyre2 PDB 5bon chain C Region: 72 - 207 Aligned: 123 Modelled: 134 Confidence: 99.6% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:probable 8-oxo-dgtp diphosphatase nudt15; PDBTitle: crystal structure of human nudt15 (mth2) Phyre2 PDB 2fb1 chain A domain 2 Region: 72 - 200 Aligned: 116 Modelled: 129 Confidence: 99.6% Identity: 16% Fold: Nudix Superfamily: Nudix Family: BT0354 N-terminal domain-like Phyre2 PDB 2fkb chain A domain 1 Region: 89 - 208 Aligned: 115 Modelled: 120 Confidence: 99.6% Identity: 20% Fold: Nudix Superfamily: Nudix Family: IPP isomerase-like Phyre2 PDB 1sjy chain A Region: 89 - 200 Aligned: 109 Modelled: 112 Confidence: 99.6% Identity: 25% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 3gz6 chain A Region: 88 - 202 Aligned: 112 Modelled: 115 Confidence: 99.6% Identity: 19% PDB header:dna binding protein/dna Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of shewanella oneidensis nrtr complexed with a 27mer2 dna Phyre2 PDB 3i9x chain A Region: 100 - 202 Aligned: 102 Modelled: 103 Confidence: 99.6% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of a mutt/nudix family protein from listeria innocua Phyre2 PDB 4kyx chain A Region: 86 - 203 Aligned: 115 Modelled: 118 Confidence: 99.6% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:adp-ribose pyrophosphatase mutt; PDBTitle: crystal structure of adp-ribose pyrophosphatase mutt from rickettsia2 felis Phyre2 PDB 2yvo chain A Region: 81 - 202 Aligned: 119 Modelled: 122 Confidence: 99.5% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of ndx2 in complex with mg2+ and amp from thermus2 thermophilus hb8 Phyre2 PDB 3hhj chain A Region: 90 - 202 Aligned: 108 Modelled: 112 Confidence: 99.5% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:mutator mutt protein; PDBTitle: crystal structure of mutator mutt from bartonella henselae Phyre2 PDB 4dyw chain A Region: 73 - 203 Aligned: 115 Modelled: 118 Confidence: 99.5% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of mutt nudix hydrolase from burkholderia2 pseudomallei Phyre2 PDB 2r5w chain A Region: 91 - 201 Aligned: 108 Modelled: 111 Confidence: 99.5% Identity: 18% PDB header:hydrolase, transferase Chain: A: PDB Molecule:nicotinamide-nucleotide adenylyltransferase; PDBTitle: crystal structure of a bifunctional nmn2 adenylyltransferase/adp ribose pyrophosphatase from3 francisella tularensis Phyre2 PDB 2rrk chain A Region: 90 - 202 Aligned: 106 Modelled: 113 Confidence: 99.5% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:ctp pyrophosphohydrolase; PDBTitle: solution structure of the e. coli orf135 protein Phyre2 PDB 5gg7 chain A Region: 76 - 200 Aligned: 105 Modelled: 125 Confidence: 99.5% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family protein; PDBTitle: crystal structure of mycobacterium smegmatis mutt1 in complex with 8-2 oxo-dgtp, 8-oxo-dgmp and pyrophosphate (i) Phyre2 PDB 1ktg chain A Region: 76 - 202 Aligned: 113 Modelled: 127 Confidence: 99.5% Identity: 23% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 1 c5t3pB_ 2 d1nqza_ 3 c5lf8A_ 4 c3gz8C_ 5 c3h95A_ 6 c3qsjA_ 7 c5bonC_ 8 d2fb1a2 9 d2fkba1 10 d1sjya_ 11 c3gz6A_ 12 c3i9xA_ 13 c4kyxA_ 14 c2yvoA_ 15 c3hhjA_ 16 c4dywA_ 17 c2r5wA_ 18 c2rrkA_ 19 c5gg7A_ 20 d1ktga_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111