1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	V	L	P	T	L	I	R	T	G	A	V	A	L	G	S	A	I	A	G	I	G	Y	A	A	L	V	E	R	N	A	F	V	L	R	E	V	T	M	P	V	L	T	P	G	S	T	P	L	R	V	L	H	I	S	D	L	H
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	L	P	N	Q	H	R	K	Q	A	W	L	R	E	L	A	S	W	E	P	D	L	V	V	N	T	G	D	N	L	A	H	P	K	A	V	P	A	V	V	Q	T	L	S	D	L	L	S	R	P	G	V	F	V	F	G	S	N	D	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	G	P	R	L	K	N	P	M	N	Y	L	T	S	P	D	H	R	V	R	G	A	A	L	P	W	Q	D	L	R	A	A	F	T	E	R	G	W	L	D	L	T	H	T	R	R	E	F	E	V	A	G	L	H	I	A	A	A	G	V
Secondary structure
SS confidence
Disorder							?								?	?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	D	P	H	I	D	R	D	R	Y	D	T	I	A	G	P	A	S	P	A	A	N	L	R	L	G	L	T	H	S	P	E	P	R	V	L	D	R	F	A	A	D	G	Y	Q	L	V	L	A	G	H	T	H	G	G	Q	L	C	L	P
Secondary structure
SS confidence
Disorder																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	Y	G	A	L	V	T	N	C	G	L	D	R	S	R	A	K	G	A	S	H	W	G	A	N	M	R	L	H	V	S	A	G	I	G	T	S	P	F	A	P	V	R	F	C	C	R	P	E	A	T	L	L	T	L	I	A	T	P	M
Secondary structure
SS confidence
Disorder												?																																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.
Sequence		G	G	R	D	S	S	S	N	L	G	R	S	Q	P	T	V	S	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 27%) Beta strand ( 26%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 2xmo chain B Region: 49 - 238 Aligned: 185 Modelled: 190 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:lmo2642 protein; PDBTitle: the crystal structure of lmo2642 Phyre2 PDB 3av0 chain A Region: 49 - 258 Aligned: 187 Modelled: 188 Confidence: 99.8% Identity: 17% PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11-rad50 bound to atp s Phyre2 PDB 4fcx chain B Region: 47 - 296 Aligned: 224 Modelled: 224 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:dna repair protein rad32; PDBTitle: s.pombe mre11 apoenzym Phyre2 PDB 3t1i chain C Region: 49 - 237 Aligned: 169 Modelled: 169 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: C: PDB Molecule:double-strand break repair protein mre11a; PDBTitle: crystal structure of human mre11: understanding tumorigenic mutations Phyre2 PDB 4fbk chain B Region: 49 - 296 Aligned: 226 Modelled: 226 Confidence: 99.8% Identity: 20% PDB header:hydrolase, protein binding Chain: B: PDB Molecule:dna repair and telomere maintenance protein nbs1,dna repair PDBTitle: crystal structure of a covalently fused nbs1-mre11 complex with one2 manganese ion per active site Phyre2 PDB 2yvt chain A domain 1 Region: 49 - 265 Aligned: 192 Modelled: 195 Confidence: 99.8% Identity: 14% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: TT1561-like Phyre2 PDB 1uf3 chain A Region: 52 - 239 Aligned: 166 Modelled: 166 Confidence: 99.8% Identity: 13% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: TT1561-like Phyre2 PDB 4yke chain A Region: 46 - 237 Aligned: 172 Modelled: 172 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:mre11; PDBTitle: crystal structure of eukaryotic mre11 catalytic domain from chaetomium2 thermophilum Phyre2 PDB 3ib7 chain A Region: 50 - 238 Aligned: 161 Modelled: 163 Confidence: 99.8% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:icc protein; PDBTitle: crystal structure of full length rv0805 Phyre2 PDB 1ii7 chain A Region: 51 - 248 Aligned: 176 Modelled: 176 Confidence: 99.8% Identity: 14% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: DNA double-strand break repair nuclease Phyre2 PDB 3auz chain A Region: 49 - 248 Aligned: 178 Modelled: 178 Confidence: 99.8% Identity: 17% PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11 with manganese Phyre2 PDB 2hy1 chain A Region: 50 - 297 Aligned: 195 Modelled: 199 Confidence: 99.8% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:rv0805; PDBTitle: crystal structure of rv0805 Phyre2 PDB 2hy1 chain A domain 1 Region: 50 - 297 Aligned: 195 Modelled: 199 Confidence: 99.8% Identity: 23% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: GpdQ-like Phyre2 PDB 2q8u chain A Region: 47 - 298 Aligned: 225 Modelled: 227 Confidence: 99.7% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:exonuclease, putative; PDBTitle: crystal structure of mre11 from thermotoga maritima msb8 (tm1635) at2 2.20 a resolution Phyre2 PDB 3qfn chain A Region: 51 - 250 Aligned: 180 Modelled: 184 Confidence: 99.7% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of streptococcal asymmetric ap4a hydrolase and2 phosphodiesterase spr1479/saph in complex with inorganic phosphate Phyre2 PDB 4lty chain D Region: 51 - 260 Aligned: 188 Modelled: 188 Confidence: 99.7% Identity: 16% PDB header:hydrolase Chain: D: PDB Molecule:exonuclease subunit sbcd; PDBTitle: crystal structure of e.coli sbcd at 1.8 a resolution Phyre2 PDB 3d03 chain A domain 1 Region: 51 - 247 Aligned: 173 Modelled: 173 Confidence: 99.7% Identity: 19% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: GpdQ-like Phyre2 PDB 3rl4 chain A Region: 45 - 295 Aligned: 207 Modelled: 230 Confidence: 99.7% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:metallophosphoesterase mpped2; PDBTitle: rat metallophosphodiesterase mpped2 g252h mutant Phyre2 PDB 3qg5 chain D Region: 51 - 237 Aligned: 165 Modelled: 164 Confidence: 99.7% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:mre11; PDBTitle: the mre11:rad50 complex forms an atp dependent molecular clamp in dna2 double-strand break repair Phyre2 PDB 6nvo chain A Region: 48 - 259 Aligned: 142 Modelled: 150 Confidence: 99.7% Identity: 25% PDB header:dna binding protein Chain: A: PDB Molecule:nuclease mpe; PDBTitle: crystal structure of pseudomonas putida nuclease mpe Phyre2 1 c2xmoB_ 2 c3av0A_ 3 c4fcxB_ 4 c3t1iC_ 5 c4fbkB_ 6 d2yvta1 7 d1uf3a_ 8 c4ykeA_ 9 c3ib7A_ 10 d1ii7a_ 11 c3auzA_ 12 c2hy1A_ 13 d2hy1a1 14 c2q8uA_ 15 c3qfnA_ 16 c4ltyD_ 17 d3d03a1 18 c3rl4A_ 19 c3qg5D_ 20 c6nvoA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225