1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	H	K	R	Y	A	P	Q	R	P	K	P	D	T	E	T	Y	I	E	K	C	T	D	R	R	Q	D	G	G	H	D	E	R	R	Q	L	L	R	P	V	S	M	L	P	P	G	Y	P	V	E	P	P	P	V	A	P	G	Y	A	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?			?	?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	Y	P	P	Y	P	A	T	P	P	G	Y	G	P	P	G	Y	G	A	P	P	S	Y	G	P	P	P	G	Y	G	P	P	L	G	Y	P	A	A	P	P	G	C	G	P	P	P	G	Y	G	P	P	L	G	Y	G	P	P	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	G	A	V	K	P	G	I	I	P	L	R	P	L	T	L	S	D	I	F	N	G	A	V	G	Y	I	R	A	N	P	K	A	T	L	G	L	T	A	M	V	V	V	T	L	Q	I	I	S	L	V	A	L	F	G	P	M	T	A	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	D	I	V	T	G	E	P	D	E	L	T	G	A	V	V	G	G	W	S	A	S	F	G	A	S	L	L	V	S	W	L	A	G	V	L	L	S	G	M	L	T	V	I	V	G	R	A	V	F	G	S	P	I	T	V	G	E	A	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?																																					?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	K	V	R	G	R	L	L	A	L	F	G	L	A	L	L	E	A	A	G	V	V	A	V	L	G	L	A	V	V	I	L	S	G	V	A	A	A	A	N	E	A	A	A	A	L	L	G	F	P	L	L	L	V	V	G	V	S	L	A
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	L	Y	V	V	L	L	F	A	P	V	L	I	V	L	E	R	L	P	I	V	E	A	I	T	R	S	F	A	L	V	R	H	G	F	W	R	V	L	G	I	R	L	L	T	V	L	V	V	G	V	V	G	N	A	I	A	A	P	F
Secondary structure
SS confidence
Disorder																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		M	I	V	G	E	I	V	T	A	V	T	A	S	D	G	S	V	T	M	R	L	V	G	A	T	L	S	A	I	G	V	T	I	G	Q	I	V	T	A	P	F	S	A	G	V	V	V	L	L	Y	T	D	R	R	I	R	A	E	A	F
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.
Sequence		D	L	V	L	Q	T	G	L	E	A	G	P	A	G	G	P	A	P	V	E	S	T	D	N	L	W	L	T	R	P	F
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?									?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 39%) Alpha helix ( 62%) Beta strand ( 0%) TM helix ( 40%) (View membrane topology prediction)

Rank Aligned region

PDB 6d79 chain A Region: 135 - 413 Aligned: 210 Modelled: 239 Confidence: 96.4% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:sulfate transporter cysz; PDBTitle: structure of cysz, a sulfate permease from pseudomonas fragi Phyre2 PDB 4nl6 chain C Region: 11 - 118 Aligned: 108 Modelled: 108 Confidence: 94.1% Identity: 17% PDB header:splicing Chain: C: PDB Molecule:survival motor neuron protein; PDBTitle: structure of the full-length form of the protein smn found in healthy2 patients Phyre2 PDB 5nik chain K Region: 281 - 418 Aligned: 130 Modelled: 135 Confidence: 91.4% Identity: 15% PDB header:transport protein Chain: K: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: structure of the macab-tolc abc-type tripartite multidrug efflux pump Phyre2 PDB 4dji chain A Region: 149 - 444 Aligned: 270 Modelled: 295 Confidence: 88.5% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 3aqp chain B Region: 146 - 355 Aligned: 179 Modelled: 188 Confidence: 78.1% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:probable secdf protein-export membrane protein; PDBTitle: crystal structure of secdf, a translocon-associated membrane protein,2 from thermus thrmophilus Phyre2 PDB 5ws4 chain A Region: 281 - 418 Aligned: 130 Modelled: 138 Confidence: 73.2% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: crystal structure of tripartite-type abc transporter macb from2 acinetobacter baumannii Phyre2 PDB 5xam chain A Region: 158 - 356 Aligned: 170 Modelled: 183 Confidence: 71.5% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:protein translocase subunit secd; PDBTitle: crystal structure of secdf in i form at 4 a resolution Phyre2 PDB 5lj7 chain B Region: 281 - 403 Aligned: 115 Modelled: 123 Confidence: 68.3% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: structure of aggregatibacter actinomycetemcomitans macb bound to atp2 (p21) Phyre2 PDB 2kog chain A Region: 325 - 361 Aligned: 37 Modelled: 37 Confidence: 66.4% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:vesicle-associated membrane protein 2; PDBTitle: lipid-bound synaptobrevin solution nmr structure Phyre2 PDB 1k6n chain H Region: 393 - 441 Aligned: 49 Modelled: 49 Confidence: 56.8% Identity: 16% PDB header:photosynthesis Chain: H: PDB Molecule:photosynthetic reaction center h subunit; PDBTitle: e(l212)a,d(l213)a double mutant structure of photosynthetic reaction2 center from rhodobacter sphaeroides Phyre2 PDB 1eys chain H domain 2 Region: 393 - 423 Aligned: 31 Modelled: 31 Confidence: 53.0% Identity: 26% Fold: Single transmembrane helix Superfamily: Photosystem II reaction centre subunit H, transmembrane region Family: Photosystem II reaction centre subunit H, transmembrane region Phyre2 PDB 6mu1 chain C Region: 195 - 356 Aligned: 137 Modelled: 137 Confidence: 52.3% Identity: 9% PDB header:membrane protein Chain: C: PDB Molecule:inositol 1,4,5-trisphosphate receptor type 1; PDBTitle: structure of full-length ip3r1 channel bound with adenophostin a Phyre2 PDB 3hd7 chain A Region: 325 - 358 Aligned: 34 Modelled: 34 Confidence: 51.8% Identity: 18% PDB header:exocytosis Chain: A: PDB Molecule:vesicle-associated membrane protein 2; PDBTitle: helical extension of the neuronal snare complex into the membrane,2 spacegroup c 1 2 1 Phyre2 PDB 2kpy chain A Region: 58 - 108 Aligned: 51 Modelled: 51 Confidence: 51.4% Identity: 29% PDB header:allergen Chain: A: PDB Molecule:major pollen allergen art v 1; PDBTitle: solution structure of the major allergen of artemisia vulgaris (art v2 1) Phyre2 PDB 5xu1 chain M Region: 286 - 403 Aligned: 117 Modelled: 118 Confidence: 51.1% Identity: 15% PDB header:transport protein Chain: M: PDB Molecule:abc transporter permeae; PDBTitle: structure of a non-canonical abc transporter from streptococcus2 pneumoniae r6 Phyre2 PDB 2i5n chain H Region: 393 - 423 Aligned: 31 Modelled: 31 Confidence: 45.8% Identity: 42% PDB header:photosynthesis Chain: H: PDB Molecule:reaction center protein h chain; PDBTitle: 1.96 a x-ray structure of photosynthetic reaction center from2 rhodopseudomonas viridis:crystals grown by microfluidic technique Phyre2 PDB 1eys chain H Region: 393 - 423 Aligned: 31 Modelled: 31 Confidence: 43.5% Identity: 26% PDB header:electron transport Chain: H: PDB Molecule:photosynthetic reaction center; PDBTitle: crystal structure of photosynthetic reaction center from a2 thermophilic bacterium, thermochromatium tepidum Phyre2 PDB 1pf4 chain A domain 2 Region: 321 - 421 Aligned: 97 Modelled: 101 Confidence: 41.7% Identity: 11% Fold: ABC transporter transmembrane region Superfamily: ABC transporter transmembrane region Family: ABC transporter transmembrane region Phyre2 PDB 3mku chain A Region: 164 - 429 Aligned: 220 Modelled: 240 Confidence: 40.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:multi antimicrobial extrusion protein (na(+)/drug PDBTitle: structure of a cation-bound multidrug and toxin compound extrusion2 (mate) transporter Phyre2 PDB 5oqt chain A Region: 148 - 348 Aligned: 179 Modelled: 181 Confidence: 36.6% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:amino acid transporter; PDBTitle: crystal structure of a bacterial cationic amino acid transporter (cat)2 homologue Phyre2 1 c6d79A_ 2 c4nl6C_ 3 c5nikK_ 4 c4djiA_ 5 c3aqpB_ 6 c5ws4A_ 7 c5xamA_ 8 c5lj7B_ 9 c2kogA_ 10 c1k6nH_ 11 d1eysh2 12 c6mu1C_ 13 c3hd7A_ 14 c2kpyA_ 15 c5xu1M_ 16 c2i5nH_ 17 c1eysH_ 18 d1pf4a2 19 c3mkuA_ 20 c5oqtA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99