1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	P	A	S	T	S	S	T	G	G	H	A	L	A	T	L	L	G	N	H	G	V	E	V	V	V	A	D	S	I	A	D	V	E	A	A	A	R	P	D	S	L	L	L	V	A	Q	T	Q	Y	L	V	D	N	A	L	L	D	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																					?						?	?	?	?										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	K	A	P	G	D	L	L	L	V	A	P	T	S	R	T	R	T	A	L	T	P	Q	L	R	I	A	A	A	S	P	F	N	S	Q	P	N	C	T	L	R	E	A	N	R	A	G	S	V	Q	W	G	P	S	D	T	Y	Q	A
Secondary structure
SS confidence
Disorder																?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?		?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	G	D	L	V	L	T	S	C	Y	G	G	A	L	V	R	F	R	A	E	G	R	T	I	T	V	V	G	S	S	N	F	M	T	N	G	G	L	L	P	A	G	N	A	A	L	A	M	N	L	A	G	N	R	P	R	L	V	W	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	P	D	H	I	E	G	E	M	S	S	P	S	S	L	S	D	L	I	P	E	N	V	H	W	T	I	W	Q	L	W	L	V	V	L	L	V	A	L	W	K	G	R	R	I	G	P	L	V	A	E	E	L	P	V	V	I	R	A	S
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?		?																													?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	T	V	E	G	R	G	R	L	Y	R	S	R	R	A	R	D	R	A	A	D	A	L	R	T	A	T	L	Q	R	L	R	P	R	L	G	V	G	A	G	A	P	A	P	A	V	V	T	T	I	A	Q	R	S	K	A	D	P	P	F
Secondary structure
SS confidence
Disorder															?	?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.
Sequence		V	A	Y	H	L	F	G	P	A	P	A	T	D	N	D	L	L	Q	L	A	R	A	L	D	D	I	E	R	Q	V	T	H	S
Secondary structure
SS confidence
Disorder								?	?		?	?																			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 45%) Beta strand ( 10%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 5fmr chain C Region: 9 - 173 Aligned: 165 Modelled: 165 Confidence: 98.8% Identity: 13% PDB header:transport protein Chain: C: PDB Molecule:intraflagellar transport protein component ift52; PDBTitle: crift52 n-terminal domain Phyre2 PDB 5fms chain A Region: 2 - 173 Aligned: 171 Modelled: 171 Confidence: 98.6% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:intraflagellar transport protein 52 homolog; PDBTitle: mmift52 n-terminal domain Phyre2 PDB 5gsl chain B Region: 8 - 150 Aligned: 143 Modelled: 143 Confidence: 96.1% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:778aa long hypothetical beta-galactosidase; PDBTitle: glycoside hydrolase a Phyre2 PDB 6ezn chain G Region: 1 - 173 Aligned: 171 Modelled: 173 Confidence: 95.2% Identity: 13% PDB header:membrane protein Chain: G: PDB Molecule:dolichyl-diphosphooligosaccharide--protein PDBTitle: cryo-em structure of the yeast oligosaccharyltransferase (ost) complex Phyre2 PDB 5xb7 chain E Region: 12 - 148 Aligned: 135 Modelled: 137 Confidence: 95.0% Identity: 19% PDB header:hydrolase Chain: E: PDB Molecule:beta-galactosidase; PDBTitle: gh42 alpha-l-arabinopyranosidase from bifidobacterium animalis subsp.2 lactis bl-04 Phyre2 PDB 1kwg chain A domain 3 Region: 12 - 149 Aligned: 130 Modelled: 138 Confidence: 94.9% Identity: 16% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: A4 beta-galactosidase middle domain Phyre2 PDB 2gk3 chain A domain 1 Region: 10 - 176 Aligned: 167 Modelled: 167 Confidence: 94.4% Identity: 13% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: STM3548-like Phyre2 PDB 1kwg chain A Region: 12 - 149 Aligned: 130 Modelled: 138 Confidence: 93.3% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of thermus thermophilus a4 beta-galactosidase Phyre2 PDB 5gsm chain B Region: 8 - 171 Aligned: 162 Modelled: 164 Confidence: 92.3% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:exo-beta-d-glucosaminidase; PDBTitle: glycoside hydrolase b with product Phyre2 PDB 4uzs chain B Region: 12 - 148 Aligned: 132 Modelled: 137 Confidence: 91.0% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of bifidobacterium bifidum beta-galactosidase Phyre2 PDB 4ojy chain A Region: 2 - 148 Aligned: 142 Modelled: 147 Confidence: 89.7% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:beta-galactosidase; PDBTitle: 3d structure of the e323a catalytic mutant of gan42b, a gh42 beta-2 galactosidase from g. stearothermophilus Phyre2 PDB 4uoz chain C Region: 2 - 148 Aligned: 142 Modelled: 147 Confidence: 84.0% Identity: 11% PDB header:hydrolase Chain: C: PDB Molecule:beta-galactosidase; PDBTitle: beta-(1,6)-galactosidase from bifidobacterium animalis subsp. lactis2 bl-04 nucleophile mutant e324a in complex with galactose Phyre2 PDB 5vym chain B Region: 12 - 70 Aligned: 54 Modelled: 59 Confidence: 83.5% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:beta-galactosidase bgab; PDBTitle: crystal structure of beta-galactosidase from bifidobacterium2 adolescentis Phyre2 PDB 3soz chain C Region: 10 - 176 Aligned: 167 Modelled: 167 Confidence: 83.5% Identity: 11% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:cytoplasmic protein stm1381; PDBTitle: cytoplasmic protein stm1381 from salmonella typhimurium lt2 Phyre2 PDB 1x7d chain A Region: 5 - 85 Aligned: 78 Modelled: 81 Confidence: 69.7% Identity: 15% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Ornithine cyclodeaminase-like Phyre2 PDB 4e5v chain A Region: 10 - 71 Aligned: 62 Modelled: 62 Confidence: 66.6% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative thua-like protein; PDBTitle: crystal structure of a putative thua-like protein (parmer_02418) from2 parabacteroides merdae atcc 43184 at 1.75 a resolution Phyre2 PDB 2iv1 chain J Region: 288 - 331 Aligned: 44 Modelled: 44 Confidence: 66.1% Identity: 20% PDB header:lyase Chain: J: PDB Molecule:cyanate hydratase; PDBTitle: site directed mutagenesis of key residues involved in the catalytic2 mechanism of cyanase Phyre2 PDB 5e9a chain B Region: 2 - 173 Aligned: 161 Modelled: 172 Confidence: 64.2% Identity: 12% PDB header:hydrolase Chain: B: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure analysis of the cold-adamped beta-galactosidase from2 rahnella sp. r3 Phyre2 PDB 1dwk chain A domain 1 Region: 288 - 323 Aligned: 36 Modelled: 36 Confidence: 58.2% Identity: 19% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: Cyanase N-terminal domain Phyre2 PDB 3tts chain D Region: 11 - 70 Aligned: 56 Modelled: 60 Confidence: 46.6% Identity: 11% PDB header:hydrolase Chain: D: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of beta-galactosidase from bacillus circulans sp.2 alkalophilus Phyre2 1 c5fmrC_ 2 c5fmsA_ 3 c5gslB_ 4 c6eznG_ 5 c5xb7E_ 6 d1kwga3 7 d2gk3a1 8 c1kwgA_ 9 c5gsmB_ 10 c4uzsB_ 11 c4ojyA_ 12 c4uozC_ 13 c5vymB_ 14 c3sozC_ 15 d1x7da_ 16 c4e5vA_ 17 c2iv1J_ 18 c5e9aB_ 19 d1dwka1 20 c3ttsD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99