1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	I	S	R	M	S	V	R	S	A	S	M	S	V	M	G	D	V	F	I	G	S	E	A	I	T	A	G	R	L	T	R	H	E	L	Q	R	W	Y	Q	P	M	F	R	G	V	Y	V	S	R	R	S	V	P	T	L	W	D	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	V	G	A	W	L	A	T	R	R	H	G	V	I	A	G	N	A	A	S	A	L	H	G	A	Q	W	V	D	V	D	V	A	I	E	L	I	S	P	T	T	R	P	Q	H	G	L	V	I	R	R	E	T	L	C	D	D	E	I	T
Secondary structure
SS confidence
Disorder																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	V	V	G	L	P	V	T	T	L	A	R	T	A	Y	D	L	G	R	H	L	S	R	G	E	A	V	A	R	L	D	A	L	M	R	A	T	P	F	S	R	D	D	V	L	L	L	A	K	R	H	A	G	A	R	G	V	R	R	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	D	V	L	P	L	V	D	G	G	A	A	S	P	K	E	T	W	L	R	L	L	L	I	D	A	G	L	P	V	P	T	T	Q	I	P	V	V	H	R	W	R	N	V	G	V	L	D	M	G	W	E	K	Y	M	V	A	A	E	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Sequence		D	G	D	Q	H	R	S	D	R	G	R	Y	V	K	D	Q	R	R	L	R	K	L	A	E	L	G	W	I	V	I	R	V	I	A	E	D	N	P	D	D	V	V	N	R	V	R	A	A	L	L	A	R	G	W	R	P
Secondary structure
SS confidence
Disorder									?																																											?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 41%) Beta strand ( 21%)

Rank Aligned region

PDB 3r3p chain B Region: 192 - 291 Aligned: 93 Modelled: 100 Confidence: 99.7% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:mobile intron protein; PDBTitle: homing endonuclease i-bth0305i catalytic domain Phyre2 PDB 3hrl chain A Region: 191 - 292 Aligned: 89 Modelled: 102 Confidence: 99.4% Identity: 25% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae Phyre2 PDB 1cw0 chain A Region: 190 - 291 Aligned: 96 Modelled: 102 Confidence: 99.3% Identity: 23% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1vsr chain A Region: 195 - 293 Aligned: 93 Modelled: 99 Confidence: 98.1% Identity: 24% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 4oq2 chain A Region: 197 - 292 Aligned: 95 Modelled: 96 Confidence: 96.2% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease pvurts1 i; PDBTitle: 5hmc specific restriction endonuclease pvurts1i Phyre2 PDB 4par chain C Region: 210 - 291 Aligned: 81 Modelled: 82 Confidence: 96.2% Identity: 21% PDB header:dna binding protein/dna Chain: C: PDB Molecule:uncharacterized protein abasi; PDBTitle: the 5-hydroxymethylcytosine-specific restriction enzyme abasi in a2 complex with product-like dna Phyre2 PDB 6rdu chain 2 Region: 227 - 276 Aligned: 50 Modelled: 50 Confidence: 95.3% Identity: 14% PDB header:proton transport Chain: 2: PDB Molecule:asa-2: polytomella f-atp synthase associated subunit 2; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1e,2 monomer-masked refinement Phyre2 PDB 1zel chain A domain 2 Region: 71 - 172 Aligned: 100 Modelled: 102 Confidence: 90.7% Identity: 19% Fold: Rv2827c C-terminal domain-like Superfamily: Rv2827c C-terminal domain-like Family: Rv2827c C-terminal domain-like Phyre2 PDB 1zel chain A Region: 27 - 172 Aligned: 143 Modelled: 146 Confidence: 89.5% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein rv2827c; PDBTitle: crystal structure of rv2827c protein from mycobacterium tuberculosis Phyre2 PDB 2fcl chain A domain 1 Region: 71 - 96 Aligned: 26 Modelled: 26 Confidence: 54.1% Identity: 27% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: TM1012-like Phyre2 PDB 1m0d chain A Region: 193 - 264 Aligned: 64 Modelled: 72 Confidence: 32.9% Identity: 16% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 PDB 4gqz chain B Region: 225 - 243 Aligned: 19 Modelled: 19 Confidence: 15.5% Identity: 16% PDB header:metal binding protein Chain: B: PDB Molecule:putative periplasmic or exported protein; PDBTitle: crystal structure of s.cuep Phyre2 PDB 2m0n chain A Region: 282 - 294 Aligned: 13 Modelled: 13 Confidence: 12.2% Identity: 46% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: solution structure of a duf3349 annotated protein from mycobacterium2 abscessus, mab_3403c. seattle structural genomics center for3 infectious disease target myaba.17112.a.a2 Phyre2 PDB 5vrv chain A Region: 228 - 288 Aligned: 60 Modelled: 61 Confidence: 11.6% Identity: 17% PDB header:hydrolase,oxidoreductase Chain: A: PDB Molecule:protein regulated by acid ph; PDBTitle: 2.05 angstrom resolution crystal structure of c-terminal domain2 (duf2156) of putative lysylphosphatidylglycerol synthetase from3 agrobacterium fabrum. Phyre2 PDB 2lky chain A Region: 282 - 294 Aligned: 13 Modelled: 13 Confidence: 9.0% Identity: 46% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of msmeg_1053, the second duf3349 annotated protein2 in the genome of mycobacterium smegmatis, seattle structural genomics3 center for infectious disease target mysma.17112.b Phyre2 PDB 1jg5 chain A Region: 260 - 273 Aligned: 14 Modelled: 14 Confidence: 7.1% Identity: 29% Fold: GTP cyclohydrolase I feedback regulatory protein, GFRP Superfamily: GTP cyclohydrolase I feedback regulatory protein, GFRP Family: GTP cyclohydrolase I feedback regulatory protein, GFRP Phyre2 PDB 1tfe chain A Region: 235 - 291 Aligned: 57 Modelled: 57 Confidence: 6.3% Identity: 14% Fold: EF-Ts domain-like Superfamily: Elongation factor Ts (EF-Ts), dimerisation domain Family: Elongation factor Ts (EF-Ts), dimerisation domain Phyre2 PDB 4p6i chain B Region: 33 - 128 Aligned: 74 Modelled: 76 Confidence: 6.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:crispr-associated endoribonuclease cas2; PDBTitle: crystal structure of the cas1-cas2 complex from escherichia coli Phyre2 PDB 2vld chain A Region: 196 - 254 Aligned: 54 Modelled: 56 Confidence: 5.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 PDB 2csb chain A domain 2 Region: 128 - 146 Aligned: 19 Modelled: 19 Confidence: 5.3% Identity: 42% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Topoisomerase V repeat domain Phyre2 1 c3r3pB_ 2 c3hrlA_ 3 d1cw0a_ 4 d1vsra_ 5 c4oq2A_ 6 c4parC_ 7 c6rdu2_ 8 d1zela2 9 c1zelA_ 10 d2fcla1 11 d1m0da_ 12 c4gqzB_ 13 c2m0nA_ 14 c5vrvA_ 15 c2lkyA_ 16 d1jg5a_ 17 d1tfea_ 18 c4p6iB_ 19 c2vldA_ 20 d2csba2 21 22