1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	K	L	S	A	G	V	L	L	Y	R	A	R	A	G	V	V	D	V	L	L	A	H	P	G	G	P	F	W	A	G	K	D	D	G	A	W	S	I	P	K	G	E	Y	T	G	G	E	D	P	W	L	A	A	R	R	E	F	S
Secondary structure
SS confidence
Disorder		?	?	?	?																							?	?		?	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	E	I	G	L	C	V	P	D	G	P	R	I	D	F	G	S	L	K	Q	S	G	G	K	V	V	T	V	F	G	V	R	A	D	L	D	I	T	D	A	R	S	S	T	F	E	L	D	W	P	K	G	S	G	K	M	R	K	F	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.
Sequence		E	V	D	R	V	S	W	F	P	V	A	R	A	R	T	K	L	L	K	G	Q	R	G	F	L	D	R	L	M	A	H	P	A	V	A	G	L	S	E	G	P	E	S	L	P	R
Secondary structure
SS confidence
Disorder																																			?	?					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 22%) Beta strand ( 35%)

Rank Aligned region

PDB 3fjy chain B Region: 4 - 158 Aligned: 148 Modelled: 155 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:probable mutt1 protein; PDBTitle: crystal structure of a probable mutt1 protein from bifidobacterium2 adolescentis Phyre2 PDB 5gg7 chain A Region: 2 - 153 Aligned: 126 Modelled: 134 Confidence: 99.9% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family protein; PDBTitle: crystal structure of mycobacterium smegmatis mutt1 in complex with 8-2 oxo-dgtp, 8-oxo-dgmp and pyrophosphate (i) Phyre2 PDB 1ktg chain A Region: 5 - 154 Aligned: 132 Modelled: 150 Confidence: 99.9% Identity: 23% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 1xsb chain A Region: 1 - 152 Aligned: 135 Modelled: 152 Confidence: 99.9% Identity: 19% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 4dyw chain A Region: 2 - 148 Aligned: 126 Modelled: 147 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of mutt nudix hydrolase from burkholderia2 pseudomallei Phyre2 PDB 3son chain B Region: 5 - 152 Aligned: 134 Modelled: 140 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:hypothetical nudix hydrolase; PDBTitle: crystal structure of a putativel nudix hydrolase (lmof2365_2679) from2 listeria monocytogenes str. 4b f2365 at 1.70 a resolution Phyre2 PDB 2b0v chain A domain 1 Region: 2 - 155 Aligned: 133 Modelled: 141 Confidence: 99.9% Identity: 17% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 3gz8 chain C Region: 2 - 153 Aligned: 134 Modelled: 138 Confidence: 99.9% Identity: 16% PDB header:dna binding protein Chain: C: PDB Molecule:mutt/nudix family protein; PDBTitle: cocrystal structure of nudix domain of shewanella oneidensis nrtr2 complexed with adp ribose Phyre2 PDB 2kdv chain A Region: 3 - 153 Aligned: 141 Modelled: 151 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:rna pyrophosphohydrolase; PDBTitle: solution structure of rna pyrophosphohydrolase rpph from2 escherichia coli Phyre2 PDB 3dku chain B Region: 2 - 158 Aligned: 134 Modelled: 143 Confidence: 99.8% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:putative phosphohydrolase; PDBTitle: crystal structure of nudix hydrolase orf153, ymfb, from escherichia2 coli k-1 Phyre2 PDB 5cfi chain C Region: 3 - 153 Aligned: 127 Modelled: 133 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:bis(5'-nucleosyl)-tetraphosphatase (diadenosine PDBTitle: structural and functional attributes of malaria parasite ap4a2 hydrolase Phyre2 PDB 2fb1 chain A domain 2 Region: 2 - 148 Aligned: 129 Modelled: 133 Confidence: 99.8% Identity: 16% Fold: Nudix Superfamily: Nudix Family: BT0354 N-terminal domain-like Phyre2 PDB 2pq1 chain B Region: 3 - 150 Aligned: 123 Modelled: 148 Confidence: 99.8% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:ap4a hydrolase; PDBTitle: crystal structure of ap4a hydrolase complexed with amp and2 atp (aq_158) from aquifex aeolicus vf5 Phyre2 PDB 5gp0 chain F Region: 1 - 147 Aligned: 130 Modelled: 138 Confidence: 99.8% Identity: 16% PDB header:hydrolase Chain: F: PDB Molecule:nudix hydrolase 1; PDBTitle: crystal structure of geraniol-nudx1 complex Phyre2 PDB 5bon chain C Region: 2 - 147 Aligned: 131 Modelled: 142 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:probable 8-oxo-dgtp diphosphatase nudt15; PDBTitle: crystal structure of human nudt15 (mth2) Phyre2 PDB 2o1c chain B Region: 4 - 149 Aligned: 136 Modelled: 146 Confidence: 99.8% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:datp pyrophosphohydrolase; PDBTitle: structure of the e. coli dihydroneopterin triphosphate2 pyrophosphohydrolase Phyre2 PDB 3fcm chain A Region: 4 - 152 Aligned: 134 Modelled: 149 Confidence: 99.8% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family; PDBTitle: crystal structure of a nudix hydrolase from clostridium perfringens Phyre2 PDB 1jkn chain A Region: 3 - 153 Aligned: 132 Modelled: 151 Confidence: 99.8% Identity: 22% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2fvv chain A Region: 2 - 150 Aligned: 125 Modelled: 126 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:diphosphoinositol polyphosphate phosphohydrolase 1; PDBTitle: human diphosphoinositol polyphosphate phosphohydrolase 1 Phyre2 PDB 2fvv chain A domain 1 Region: 2 - 150 Aligned: 125 Modelled: 126 Confidence: 99.8% Identity: 19% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 1 c3fjyB_ 2 c5gg7A_ 3 d1ktga_ 4 d1xsba_ 5 c4dywA_ 6 c3sonB_ 7 d2b0va1 8 c3gz8C_ 9 c2kdvA_ 10 c3dkuB_ 11 c5cfiC_ 12 d2fb1a2 13 c2pq1B_ 14 c5gp0F_ 15 c5bonC_ 16 c2o1cB_ 17 c3fcmA_ 18 d1jkna_ 19 c2fvvA_ 20 d2fvva1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111