1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	Q	D	R	S	D	N	T	A	L	R	R	G	L	R	I	A	L	R	G	R	R	D	P	L	P	V	A	G	R	R	S	R	T	S	G	G	I	D	D	L	H	T	R	K	V	L	D	L	T	I	R	L	A	E	V	M	L	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?				?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	G	S	G	T	A	D	V	V	A	T	A	Q	D	V	A	Q	A	Y	Q	L	T	D	C	V	V	D	I	T	V	T	T	I	I	V	S	A	L	A	T	T	D	T	P	P	V	T	I	M	R	S	V	R	T	R	S	T	D	Y	S
Secondary structure
SS confidence
Disorder																																																					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	L	A	E	L	D	R	L	V	Q	R	I	T	S	G	G	V	A	V	D	Q	A	H	E	A	M	D	E	L	T	E	R	P	H	P	Y	P	R	W	L	A	T	A	G	A	A	G	F	A	L	G	V	A	M	L	L	G	G	T	W
Secondary structure
SS confidence
Disorder																?																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	T	C	V	L	A	A	V	T	S	G	V	I	D	R	L	G	R	L	L	N	R	I	G	T	P	L	F	F	Q	R	V	F	G	A	G	I	A	T	L	V	A	V	A	A	Y	L	I	A	G	Q	D	P	T	A	L	V	A	T	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	V	V	L	L	S	G	M	T	L	V	G	S	M	Q	D	A	V	T	G	Y	M	L	T	A	L	A	R	L	G	D	A	L	F	L	T	A	G	I	V	V	G	I	L	I	S	L	R	G	V	T	N	A	G	I	Q	I	E	L	H
Secondary structure
SS confidence
Disorder																				?	?	?																																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	D	A	T	T	T	L	A	T	P	G	M	P	L	P	I	L	V	A	V	S	G	A	A	L	S	G	V	C	L	T	I	A	S	Y	A	P	L	R	S	V	A	T	A	G	L	S	A	G	L	A	E	L	V	L	I	G	L	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	G	F	G	R	V	V	A	T	W	T	A	A	I	G	V	G	F	L	A	T	L	I	S	I	R	R	Q	A	P	A	L	V	T	A	T	A	G	I	M	P	M	L	P	G	L	A	V	F	R	A	V	F	A	F	A	V	N	D	T
Secondary structure
SS confidence
Disorder		?																																																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	D	G	G	L	T	Q	L	L	E	A	A	A	T	A	L	A	L	G	S	G	V	V	L	G	E	F	L	A	S	P	L	R	Y	G	A	G	R	I	G	D	L	F	R	I	E	G	P	P	G	L	R	R	A	V	G	R	V	V	R
Secondary structure
SS confidence
Disorder																																		?	?	?									?	?	?	?	?	?	?	?	?	?		?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.
Sequence		L	Q	P	A	K	S	Q	Q	P	T	G	T	G	G	Q	R	W	R	S	V	A	L	E	P	T	T	A	D	D	V	D	A	G	Y	R	G	D	W	P	A	T	C	T	S	A	T	E	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 65%) Beta strand ( 4%) TM helix ( 37%) (View membrane topology prediction)

Rank Aligned region

PDB 2pp4 chain A domain 1 Region: 123 - 155 Aligned: 33 Modelled: 33 Confidence: 79.7% Identity: 18% Fold: TAFH domain-like Superfamily: TAFH domain-like Family: TAFH domain-like Phyre2 PDB 2y0s chain J Region: 118 - 148 Aligned: 31 Modelled: 31 Confidence: 48.2% Identity: 16% PDB header:transferase Chain: J: PDB Molecule:rna polymerase subunit 13; PDBTitle: crystal structure of sulfolobus shibatae rna polymerase in p21 space2 group Phyre2 PDB 2y0s chain Q Region: 118 - 148 Aligned: 31 Modelled: 31 Confidence: 48.2% Identity: 16% PDB header:transferase Chain: Q: PDB Molecule:rna polymerase subunit 13; PDBTitle: crystal structure of sulfolobus shibatae rna polymerase in p21 space2 group Phyre2 PDB 4b1p chain J Region: 118 - 151 Aligned: 34 Modelled: 34 Confidence: 47.6% Identity: 18% PDB header:transferase/dna Chain: J: PDB Molecule:rna polymerase subunit 13; PDBTitle: archaeal rnap-dna binary complex at 4.32ang Phyre2 PDB 4ayb chain Q Region: 118 - 151 Aligned: 34 Modelled: 34 Confidence: 46.4% Identity: 18% PDB header:transferase Chain: Q: PDB Molecule:dna-directed rna polymerase; PDBTitle: rnap at 3.2ang Phyre2 PDB 5xj6 chain A Region: 154 - 261 Aligned: 97 Modelled: 108 Confidence: 43.8% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:glycerol-3-phosphate acyltransferase; PDBTitle: crystal structure of plsy (ygih), an integral membrane glycerol 3-2 phosphate acyltransferase - the glycerol 3-phosphate form Phyre2 PDB 1vp7 chain A Region: 120 - 148 Aligned: 29 Modelled: 29 Confidence: 41.6% Identity: 31% Fold: Spectrin repeat-like Superfamily: XseB-like Family: XseB-like Phyre2 PDB 5x3x chain M Region: 156 - 280 Aligned: 116 Modelled: 125 Confidence: 41.2% Identity: 15% PDB header:transport protein Chain: M: PDB Molecule:cobalt transport protein cbim; PDBTitle: 2.8a resolution structure of a cobalt energy-coupling factor2 transporter-cbimqo Phyre2 PDB 5a40 chain C Region: 338 - 450 Aligned: 113 Modelled: 113 Confidence: 40.6% Identity: 17% PDB header:transport protein Chain: C: PDB Molecule:putative fluoride ion transporter crcb; PDBTitle: crystal structure of a dual topology fluoride ion channel. Phyre2 PDB 3hkz chain Y Region: 118 - 152 Aligned: 35 Modelled: 35 Confidence: 38.0% Identity: 11% PDB header:transferase Chain: Y: PDB Molecule:dna-directed rna polymerase subunit 13; PDBTitle: the x-ray crystal structure of rna polymerase from archaea Phyre2 PDB 1vp7 chain B Region: 120 - 148 Aligned: 29 Modelled: 29 Confidence: 34.7% Identity: 31% Fold: Spectrin repeat-like Superfamily: XseB-like Family: XseB-like Phyre2 PDB 3hkz chain Z Region: 118 - 152 Aligned: 35 Modelled: 35 Confidence: 33.6% Identity: 11% PDB header:transferase Chain: Z: PDB Molecule:dna-directed rna polymerase subunit 13; PDBTitle: the x-ray crystal structure of rna polymerase from archaea Phyre2 PDB 4m5b chain A Region: 156 - 228 Aligned: 73 Modelled: 73 Confidence: 32.4% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:cobalamin biosynthesis protein cbim; PDBTitle: crystal structure of an truncated transition metal transporter Phyre2 PDB 4m5c chain A Region: 156 - 228 Aligned: 73 Modelled: 73 Confidence: 32.4% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:cobalamin biosynthesis protein cbim; PDBTitle: crystal structure of an truncated transition metal transporter Phyre2 PDB 4b1o chain Q Region: 118 - 151 Aligned: 34 Modelled: 34 Confidence: 32.2% Identity: 18% PDB header:transferase/dna Chain: Q: PDB Molecule:rna polymerase subunit 13; PDBTitle: archaeal rnap-dna binary complex at 4.32ang Phyre2 PDB 2jvd chain A Region: 117 - 145 Aligned: 29 Modelled: 29 Confidence: 30.1% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the folded n-terminal fragment of2 upf0291 protein ynzc from bacillus subtilis. northeast3 structural genomics target sr384-1-46 Phyre2 PDB 3bhp chain A Region: 116 - 145 Aligned: 30 Modelled: 29 Confidence: 27.3% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: crystal structure of upf0291 protein ynzc from bacillus2 subtilis at resolution 2.0 a. northeast structural3 genomics consortium target sr384 Phyre2 PDB 5n9q chain A Region: 114 - 149 Aligned: 36 Modelled: 36 Confidence: 27.0% Identity: 3% PDB header:transferase Chain: A: PDB Molecule:inactive poly [adp-ribose] polymerase rcd1; PDBTitle: structure of a. thaliana rcd1(468-567) Phyre2 PDB 2hep chain A domain 1 Region: 120 - 145 Aligned: 26 Modelled: 26 Confidence: 26.0% Identity: 15% Fold: Long alpha-hairpin Superfamily: YnzC-like Family: YznC-like Phyre2 PDB 2hep chain A Region: 120 - 145 Aligned: 26 Modelled: 26 Confidence: 26.0% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0291 protein ynzc; PDBTitle: solution nmr structure of the upf0291 protein ynzc from2 bacillus subtilis. northeast structural genomics target3 sr384. Phyre2 1 d2pp4a1 2 c2y0sJ_ 3 c2y0sQ_ 4 c4b1pJ_ 5 c4aybQ_ 6 c5xj6A_ 7 d1vp7a_ 8 c5x3xm_ 9 c5a40C_ 10 c3hkzY_ 11 d1vp7b_ 12 c3hkzZ_ 13 c4m5bA_ 14 c4m5cA_ 15 c4b1oQ_ 16 c2jvdA_ 17 c3bhpA_ 18 c5n9qA_ 19 d2hepa1 20 c2hepA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99