1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	A	V	P	S	D	L	T	P	R	V	W	P	A	M	L	T	W	R	A	Q	D	I	S	R	M	E	S	V	R	V	Q	L	S	G	K	R	I	R	A	N	G	R	I	V	A	A	A	T	A	N	N	P	A	F	G	A	H	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?	?		?	?																						?	?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	L	Q	T	D	E	T	G	A	T	K	R	F	G	L	T	V	T	L	A	E	R	E	R	Q	L	A	I	A	R	D	E	E	N	M	W	L	V	T	D	H	Q	G	E	R	R	A	A	Y	N	G	A	L	D	I	D	L	V	F	S
Secondary structure
SS confidence
Disorder																																										?			?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	F	F	N	A	L	P	I	R	R	L	G	L	H	E	R	A	E	S	I	A	L	P	V	V	Y	V	N	V	P	E	M	S	V	D	A	A	T	V	S	Y	T	S	E	G	R	L	D	G	I	K	L	R	S	P	V	A	D	T	T
Secondary structure
SS confidence
Disorder													?			?	?	?	?																				?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.
Sequence		V	T	V	D	S	D	G	F	I	V	D	Y	P	G	L	A	E	R	M
Secondary structure
SS confidence
Disorder																			?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 6%) Beta strand ( 53%)

Rank Aligned region

PDB 2h1t chain A domain 1 Region: 15 - 199 Aligned: 176 Modelled: 185 Confidence: 100.0% Identity: 27% Fold: Spiral beta-roll Superfamily: PA1994-like Family: PA1994-like Phyre2 PDB 1jiw chain I Region: 19 - 106 Aligned: 77 Modelled: 88 Confidence: 45.3% Identity: 14% Fold: Streptavidin-like Superfamily: beta-Barrel protease inhibitors Family: Metalloprotease inhibitor Phyre2 PDB 5aj1 chain A Region: 192 - 199 Aligned: 8 Modelled: 8 Confidence: 19.9% Identity: 50% PDB header:structural protein Chain: A: PDB Molecule:swi/snf-related matrix-associated actin-dependent regulator PDBTitle: solution structure of the smarc domain Phyre2 PDB 2k7m chain A Region: 105 - 129 Aligned: 25 Modelled: 25 Confidence: 14.1% Identity: 28% PDB header:membrane protein Chain: A: PDB Molecule:gap junction alpha-5 protein; PDBTitle: structure of the connexin40 carboxyl terminal domain Phyre2 PDB 4d77 chain A Region: 180 - 193 Aligned: 14 Modelled: 14 Confidence: 12.0% Identity: 29% PDB header:signaling protein Chain: A: PDB Molecule:gliomedin; PDBTitle: high-resolution structure of the extracellular olfactomedin2 domain from gliomedin Phyre2 PDB 2gtj chain A Region: 86 - 126 Aligned: 41 Modelled: 41 Confidence: 12.0% Identity: 22% PDB header:signaling protein Chain: A: PDB Molecule:fyn-binding protein; PDBTitle: reduced form of adap hsh3-n-domain Phyre2 PDB 6hom chain D Region: 114 - 125 Aligned: 12 Modelled: 12 Confidence: 10.8% Identity: 50% PDB header:gene regulation Chain: D: PDB Molecule:ccr4-not transcription complex subunit 4, isoform l; PDBTitle: drosophila not4 cbm peptide bound to human caf40 Phyre2 PDB 5tvz chain A Region: 52 - 105 Aligned: 53 Modelled: 54 Confidence: 10.7% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:nucleoporin pom152; PDBTitle: solution nmr structure of saccharomyces cerevisiae pom152 ig-like2 repeat, residues 718-820 Phyre2 PDB 5amo chain A Region: 180 - 193 Aligned: 14 Modelled: 14 Confidence: 10.6% Identity: 29% PDB header:signaling protein Chain: A: PDB Molecule:noelin; PDBTitle: structure of a mouse olfactomedin-1 disulfide-linked dimer of the2 olfactomedin domain and part of the coiled coil Phyre2 PDB 4wxu chain A Region: 180 - 193 Aligned: 14 Modelled: 14 Confidence: 10.1% Identity: 36% PDB header:protein binding Chain: A: PDB Molecule:myocilin; PDBTitle: crystal structure of the selenomthionine incorporated myocilin2 olfactomedin domain e396d variant. Phyre2 PDB 3m4w chain H Region: 121 - 128 Aligned: 8 Modelled: 8 Confidence: 9.9% Identity: 63% PDB header:signaling protein/signaling protein Chain: H: PDB Molecule:sigma-e factor negative regulatory protein; PDBTitle: structural basis for the negative regulation of bacterial stress2 response by rseb Phyre2 PDB 6hom chain B Region: 116 - 125 Aligned: 10 Modelled: 10 Confidence: 9.3% Identity: 50% PDB header:gene regulation Chain: B: PDB Molecule:ccr4-not transcription complex subunit 4, isoform l; PDBTitle: drosophila not4 cbm peptide bound to human caf40 Phyre2 PDB 6hon chain D Region: 116 - 125 Aligned: 10 Modelled: 10 Confidence: 9.3% Identity: 50% PDB header:gene regulation Chain: D: PDB Molecule:ccr4-not transcription complex subunit 4, isoform l; PDBTitle: drosophila not4 cbm peptide bound to human caf40 Phyre2 PDB 2w56 chain B Region: 86 - 129 Aligned: 41 Modelled: 44 Confidence: 9.2% Identity: 22% PDB header:unknown function Chain: B: PDB Molecule:vc0508; PDBTitle: structure of the hypothetical protein vc0508 from vibrio cholerae2 vsp-ii pathogenicity island Phyre2 PDB 6hon chain B Region: 116 - 125 Aligned: 10 Modelled: 10 Confidence: 9.1% Identity: 50% PDB header:gene regulation Chain: B: PDB Molecule:ccr4-not transcription complex subunit 4, isoform l; PDBTitle: drosophila not4 cbm peptide bound to human caf40 Phyre2 PDB 6elu chain J Region: 117 - 131 Aligned: 15 Modelled: 15 Confidence: 8.9% Identity: 27% PDB header:antitoxin Chain: J: PDB Molecule:serum resistance associated; vsg protein; PDBTitle: structure of serum resistance associated protein from t. b.2 rhodesiense Phyre2 PDB 1jz8 chain A domain 4 Region: 110 - 147 Aligned: 38 Modelled: 38 Confidence: 8.8% Identity: 18% Fold: Supersandwich Superfamily: Galactose mutarotase-like Family: beta-Galactosidase, domain 5 Phyre2 PDB 2d81 chain A domain 1 Region: 184 - 194 Aligned: 11 Modelled: 11 Confidence: 8.7% Identity: 36% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: PHB depolymerase-like Phyre2 PDB 1o1z chain A Region: 186 - 199 Aligned: 14 Modelled: 14 Confidence: 8.0% Identity: 36% Fold: TIM beta/alpha-barrel Superfamily: PLC-like phosphodiesterases Family: Glycerophosphoryl diester phosphodiesterase Phyre2 PDB 3bb9 chain A domain 1 Region: 56 - 98 Aligned: 43 Modelled: 43 Confidence: 7.9% Identity: 9% Fold: Cystatin-like Superfamily: NTF2-like Family: SO0125-like Phyre2 1 d2h1ta1 2 d1jiwi_ 3 c5aj1A_ 4 c2k7mA_ 5 c4d77A_ 6 c2gtjA_ 7 c6homD_ 8 c5tvzA_ 9 c5amoA_ 10 c4wxuA_ 11 c3m4wH_ 12 c6homB_ 13 c6honD_ 14 c2w56B_ 15 c6honB_ 16 c6eluJ_ 17 d1jz8a4 18 d2d81a1 19 d1o1za_ 20 d3bb9a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39