1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	F	M	D	A	Q	A	S	F	Q	T	Q	S	R	T	L	A	R	V	R	G	D	L	V	D	G	F	R	R	H	E	L	W	L	H	L	G	W	Q	D	I	K	Q	R	Y	R	R	S	V	L	G	P	F	W	I	T	I	A	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	T	T	A	V	A	M	G	G	L	Y	S	K	L	F	R	L	E	L	S	E	H	L	P	Y	V	T	L	G	L	I	V	W	N	L	I	N	A	A	I	L	D	G	A	E	V	F	V	A	N	E	G	L	I	K	Q	L	P	A	P
Secondary structure
SS confidence
Disorder																	?	?	?																																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	S	V	H	V	Y	R	L	V	W	R	Q	M	I	F	F	A	H	N	I	V	I	Y	F	V	I	A	I	I	F	P	K	P	W	S	W	A	D	L	S	F	L	P	A	L	A	L	I	F	L	N	C	V	W	V	S	L	C	F	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	L	A	T	R	Y	R	D	I	G	P	L	L	F	S	V	V	Q	L	L	F	F	M	T	P	I	I	W	N	D	E	T	L	R	R	Q	G	A	G	R	W	S	S	I	V	E	L	N	P	L	L	H	Y	L	D	I	V	R	A	P
Secondary structure
SS confidence
Disorder																																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence		L	L	G	A	H	Q	E	L	R	H	W	L	V	V	L	V	L	T	V	V	G	W	M	L	A	A	F	A	M	R	Q	Y	R	A	R	V	P	Y	W	V
Secondary structure
SS confidence
Disorder																																							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 81%) Beta strand ( 0%) TM helix ( 55%) (View membrane topology prediction)

Rank Aligned region

PDB 6an7 chain D Region: 32 - 279 Aligned: 243 Modelled: 248 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: D: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 6an7 chain C Region: 32 - 279 Aligned: 244 Modelled: 248 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: C: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 5do7 chain B Region: 3 - 275 Aligned: 268 Modelled: 273 Confidence: 99.9% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 8; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5do7 chain A Region: 30 - 277 Aligned: 243 Modelled: 248 Confidence: 99.8% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family g member 5; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5njg chain B Region: 31 - 275 Aligned: 239 Modelled: 245 Confidence: 99.8% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: part of the structure that could be2 built de novo Phyre2 PDB 5nj3 chain B Region: 11 - 275 Aligned: 260 Modelled: 265 Confidence: 99.8% Identity: 9% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: complete structure Phyre2 PDB 5xjy chain A Region: 81 - 268 Aligned: 185 Modelled: 188 Confidence: 92.2% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family a member 1; PDBTitle: cryo-em structure of human abca1 Phyre2 PDB 6e11 chain F Region: 14 - 42 Aligned: 29 Modelled: 29 Confidence: 11.4% Identity: 14% PDB header:protein transport Chain: F: PDB Molecule:exported protein 2; PDBTitle: ptex core complex in the resetting (compact) state Phyre2 PDB 6f0k chain D Region: 114 - 185 Aligned: 72 Modelled: 72 Confidence: 9.9% Identity: 7% PDB header:membrane protein Chain: D: PDB Molecule:actd; PDBTitle: alternative complex iii Phyre2 PDB 5wuf chain A Region: 236 - 275 Aligned: 40 Modelled: 40 Confidence: 9.8% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:putative membrane protein; PDBTitle: structural basis for conductance through tric cation channels Phyre2 PDB 4naw chain G Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 17% PDB header:protein transport/ligase Chain: G: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5-atg16n in complex with a2 fragment of atg3 Phyre2 PDB 4naw chain O Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 17% PDB header:protein transport/ligase Chain: O: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5-atg16n in complex with a2 fragment of atg3 Phyre2 PDB 4naw chain C Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 17% PDB header:protein transport/ligase Chain: C: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5-atg16n in complex with a2 fragment of atg3 Phyre2 PDB 4gdl chain C Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 17% PDB header:protein binding Chain: C: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5 conjugate in complex with an n-2 terminal fragment of atg16l1 Phyre2 PDB 4naw chain K Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 17% PDB header:protein transport/ligase Chain: K: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5-atg16n in complex with a2 fragment of atg3 Phyre2 PDB 4gdk chain C Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 17% PDB header:protein binding Chain: C: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5 conjugate in complex with an n-2 terminal fragment of atg16l1 Phyre2 PDB 4gdk chain F Region: 17 - 46 Aligned: 30 Modelled: 30 Confidence: 8.8% Identity: 17% PDB header:protein binding Chain: F: PDB Molecule:autophagy-related protein 16-1; PDBTitle: crystal structure of human atg12~atg5 conjugate in complex with an n-2 terminal fragment of atg16l1 Phyre2 PDB 4y0l chain A Region: 2 - 24 Aligned: 23 Modelled: 23 Confidence: 7.2% Identity: 30% PDB header:membrane protein Chain: A: PDB Molecule:putative membrane protein mmpl11; PDBTitle: mycobacterial membrane protein mmpl11d2 Phyre2 PDB 2na6 chain C Region: 255 - 275 Aligned: 21 Modelled: 21 Confidence: 7.0% Identity: 33% PDB header:apoptosis Chain: C: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 2na6 chain A Region: 255 - 275 Aligned: 21 Modelled: 21 Confidence: 7.0% Identity: 33% PDB header:apoptosis Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 1 c6an7D_ 2 c6an7C_ 3 c5do7B_ 4 c5do7A_ 5 c5njgB_ 6 c5nj3B_ 7 c5xjyA_ 8 c6e11F_ 9 c6f0kD_ 10 c5wufA_ 11 c4nawG_ 12 c4nawO_ 13 c4nawC_ 14 c4gdlC_ 15 c4nawK_ 16 c4gdkC_ 17 c4gdkF_ 18 c4y0lA_ 19 c2na6C_ 20 c2na6A_ 21 22 23