1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	S	R	R	K	S	P	Q	F	G	H	E	M	G	A	F	T	S	A	R	A	R	E	V	L	V	A	L	G	Q	L	A	A	A	V	V	V	A	V	G	V	A	V	V	S	L	L	A	I	A	R	V	E	W	P	A	F	P	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?		?					?	?	?	?	?	?	?																														?	?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	N	Q	L	H	A	L	T	T	V	G	Q	V	G	C	L	A	G	L	V	G	I	G	W	L	W	R	H	G	R	F	R	R	L	A	R	L	G	G	L	V	L	V	S	A	F	T	V	V	T	L	G	M	P	L	G	A	T	K	L
Secondary structure
SS confidence
Disorder			?																																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	L	F	G	I	S	V	D	Q	Q	F	R	T	E	Y	L	T	R	L	T	D	T	A	A	L	R	D	M	T	Y	I	G	L	P	P	F	Y	P	P	G	W	F	W	I	G	G	R	A	A	A	L	T	G	T	P	A	W	E	M	F
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	P	W	A	I	T	S	M	A	I	A	V	A	V	A	L	V	L	W	W	R	M	I	R	F	E	Y	A	L	L	V	T	V	A	T	A	A	V	M	L	A	Y	S	S	P	E	P	Y	A	A	M	I	T	V	L	L	P	P	M	L
Secondary structure
SS confidence
Disorder																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	T	W	S	G	L	G	A	R	D	R	Q	G	W	A	A	V	V	G	A	G	V	F	L	G	F	A	A	T	W	Y	T	L	L	V	A	Y	G	A	F	T	V	V	L	M	A	L	L	L	A	G	S	R	L	Q	S	G	I	K
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?	?	?	?																																										?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	A	V	D	P	L	C	R	L	A	V	V	G	A	I	A	A	A	I	G	S	T	T	W	L	P	Y	L	L	R	A	A	R	D	P	V	S	D	T	G	S	A	Q	H	Y	L	P	A	D	G	A	A	L	T	F	P	M	L	Q	F
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	L	L	G	A	I	C	L	L	G	T	L	W	L	V	M	R	A	R	S	S	A	P	A	G	A	L	A	I	G	V	L	A	V	Y	L	W	S	L	L	S	M	L	A	T	L	A	R	T	T	L	L	S	F	R	L	Q	P	T	L
Secondary structure
SS confidence
Disorder																									?																								?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		S	V	L	L	V	A	A	G	A	F	G	F	V	E	A	V	Q	A	L	G	K	R	G	R	G	V	I	P	M	A	A	A	I	G	L	A	G	A	I	A	F	S	Q	D	I	P	D	V	L	R	P	D	L	T	I	A	Y	T	D	T
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		D	G	Y	G	Q	R	G	D	R	R	P	P	G	S	E	K	Y	Y	P	A	I	D	A	A	I	R	R	V	T	G	K	R	R	D	R	T	V	V	L	T	A	D	Y	S	F	L	S	Y	Y	P	Y	W	G	F	Q	G	L	T	P	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?													?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		Y	A	N	P	L	A	Q	F	D	K	R	A	T	Q	I	D	S	W	S	G	L	S	T	A	D	E	F	I	A	A	L	D	K	L	P	W	Q	P	P	T	V	F	L	M	R	H	G	A	H	N	S	Y	T	L	R	L	A	Q	D	V
Secondary structure
SS confidence
Disorder																		?	?	?	?	?		?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.
Sequence		Y	P	N	Q	P	N	V	R	R	Y	T	V	D	L	R	T	A	L	F	A	D	P	R	F	V	V	E	D	I	G	P	F	V	L	A	I	R	K	P	Q	E	S	A
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 65%) Beta strand ( 5%) TM helix ( 41%) (View membrane topology prediction)

Rank Aligned region

PDB 5f15 chain A Region: 128 - 605 Aligned: 443 Modelled: 454 Confidence: 94.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 6p25 chain A Region: 157 - 345 Aligned: 186 Modelled: 189 Confidence: 73.7% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 3waj chain A Region: 132 - 458 Aligned: 305 Modelled: 312 Confidence: 72.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 4ymk chain A Region: 392 - 483 Aligned: 92 Modelled: 92 Confidence: 69.4% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa desaturase 1; PDBTitle: crystal structure of stearoyl-coenzyme a desaturase 1 Phyre2 PDB 6ezn chain F Region: 91 - 520 Aligned: 403 Modelled: 430 Confidence: 57.7% Identity: 12% PDB header:membrane protein Chain: F: PDB Molecule:dolichyl-diphosphooligosaccharide--protein PDBTitle: cryo-em structure of the yeast oligosaccharyltransferase (ost) complex Phyre2 PDB 4fyp chain A Region: 493 - 544 Aligned: 52 Modelled: 52 Confidence: 57.0% Identity: 17% PDB header:plant protein Chain: A: PDB Molecule:vegetative storage protein 1; PDBTitle: crystal structure of plant vegetative storage protein Phyre2 PDB 1okg chain A Region: 460 - 537 Aligned: 71 Modelled: 74 Confidence: 53.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:possible 3-mercaptopyruvate sulfurtransferase; PDBTitle: 3-mercaptopyruvate sulfurtransferase from leishmania major Phyre2 PDB 4dh4 chain A Region: 487 - 538 Aligned: 48 Modelled: 52 Confidence: 50.6% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:mif; PDBTitle: macrophage migration inhibitory factor toxoplasma gondii Phyre2 PDB 5ir6 chain B Region: 255 - 463 Aligned: 209 Modelled: 209 Confidence: 50.4% Identity: 11% PDB header:oxidoreductase Chain: B: PDB Molecule:bd-type quinol oxidase subunit ii; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 4nsm chain A Region: 529 - 558 Aligned: 30 Modelled: 30 Confidence: 48.1% Identity: 43% PDB header:structural protein Chain: A: PDB Molecule:collagen-like protein sclb; PDBTitle: crystal structure of the streptococcal collagen-like protein 22 globular domain from invasive m3-type group a streptococcus Phyre2 PDB 3utn chain X Region: 460 - 537 Aligned: 69 Modelled: 78 Confidence: 45.9% Identity: 22% PDB header:transferase Chain: X: PDB Molecule:thiosulfate sulfurtransferase tum1; PDBTitle: crystal structure of tum1 protein from saccharomyces cerevisiae Phyre2 PDB 6cuq chain B Region: 488 - 538 Aligned: 47 Modelled: 51 Confidence: 45.9% Identity: 11% PDB header:cytokine Chain: B: PDB Molecule:macrophage migration inhibitory factor-like protein; PDBTitle: crystal structure of macrophage migration inhibitory factor-like2 protein (ehmif) from entamoeba histolytica Phyre2 PDB 1y5i chain C domain 1 Region: 347 - 405 Aligned: 59 Modelled: 59 Confidence: 42.1% Identity: 24% Fold: Heme-binding four-helical bundle Superfamily: Respiratory nitrate reductase 1 gamma chain Family: Respiratory nitrate reductase 1 gamma chain Phyre2 PDB 2m7g chain A Region: 446 - 494 Aligned: 49 Modelled: 49 Confidence: 38.6% Identity: 24% PDB header:cell adhesion, structural protein, elect Chain: A: PDB Molecule:geopilin domain 1 protein; PDBTitle: structure of the type iva major pilin from the electrically conductive2 bacterial nanowires of geobacter sulfurreducens Phyre2 PDB 2ji7 chain A domain 3 Region: 516 - 574 Aligned: 59 Modelled: 59 Confidence: 38.1% Identity: 15% Fold: Thiamin diphosphate-binding fold (THDP-binding) Superfamily: Thiamin diphosphate-binding fold (THDP-binding) Family: Pyruvate oxidase and decarboxylase PP module Phyre2 PDB 1ypz chain E domain 2 Region: 575 - 604 Aligned: 27 Modelled: 30 Confidence: 38.0% Identity: 37% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: C1 set domains (antibody constant domain-like) Phyre2 PDB 5un4 chain C Region: 486 - 541 Aligned: 52 Modelled: 56 Confidence: 37.8% Identity: 17% PDB header:hydrolase Chain: C: PDB Molecule:4-oxalocrotonate tautomerase; PDBTitle: crystal structure of native fused 4-ot Phyre2 PDB 1yo8 chain A Region: 597 - 634 Aligned: 38 Modelled: 38 Confidence: 37.7% Identity: 26% PDB header:cell adhesion Chain: A: PDB Molecule:thrombospondin-2; PDBTitle: structure of the c-terminal domain of human thrombospondin-2 Phyre2 PDB 1ux6 chain A Region: 597 - 629 Aligned: 33 Modelled: 33 Confidence: 36.2% Identity: 30% PDB header:cell adhesion Chain: A: PDB Molecule:thrombospondin-1; PDBTitle: structure of a thrombospondin c-terminal fragment reveals a novel2 calcium core in the type 3 repeats Phyre2 PDB 3zm8 chain A Region: 145 - 167 Aligned: 14 Modelled: 23 Confidence: 36.0% Identity: 43% PDB header:hydrolase Chain: A: PDB Molecule:gh26 endo-beta-1,4-mannanase; PDBTitle: crystal structure of podospora anserina gh26-cbm352 beta-(1,4)-mannanase Phyre2 1 c5f15A_ 2 c6p25A_ 3 c3wajA_ 4 c4ymkA_ 5 c6eznF_ 6 c4fypA_ 7 c1okgA_ 8 c4dh4A_ 9 c5ir6B_ 10 c4nsmA_ 11 c3utnX_ 12 c6cuqB_ 13 d1y5ic1 14 c2m7gA_ 15 d2ji7a3 16 d1ypze2 17 c5un4C_ 18 c1yo8A_ 19 c1ux6A_ 20 c3zm8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99