1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	L	G	M	H	Q	A	G	H	V	G	T	H	E	R	R	A	A	A	T	R	R	S	A	L	T	A	A	G	L	A	V	V	G	A	G	V	L	G	A	S	A	C	S	P	Q	K	S	P	Q	P	S	S	P	R	L	P	D	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?						?	?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	L	I	T	L	G	V	A	A	G	P	P	P	T	P	S	R	V	G	I	S	S	V	L	K	I	G	R	D	L	Y	V	I	D	C	G	L	G	S	L	N	A	F	T	N	A	G	L	Q	F	D	D	L	K	A	M	F	I	T	H
Secondary structure
SS confidence
Disorder															?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	H	T	D	H	I	V	D	Y	Y	N	F	F	L	S	G	G	F	L	A	P	P	G	R	A	P	V	L	V	Y	G	P	G	P	A	G	G	L	P	P	S	E	V	G	N	P	N	P	A	T	V	N	P	A	N	P	T	P	G	L
Secondary structure
SS confidence
Disorder																			?	?	?	?	?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	A	T	E	A	L	H	R	A	F	A	Y	T	S	N	I	F	I	R	D	Y	G	I	D	N	V	A	D	L	V	K	V	T	E	I	G	L	P	P	G	S	D	Y	R	N	R	A	P	K	M	S	P	F	S	V	A	S	D	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	V	S	V	T	A	T	L	V	S	H	Y	D	V	Y	P	A	F	G	F	R	F	D	L	K	K	S	G	V	S	V	T	F	S	G	D	T	T	K	S	D	N	L	I	T	L	A	Q	G	T	D	I	L	V	H	E	A	V	F	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	D	T	A	Y	F	G	N	A	F	P	P	N	Y	L	V	N	S	H	T	S	A	E	Q	V	G	E	V	A	A	A	A	K	P	K	Q	L	I	L	S	H	Y	A	P	D	D	L	P	D	S	Q	W	L	D	K	I	K	K	N	Y
Secondary structure
SS confidence
Disorder						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.
Sequence		S	G	M	T	T	I	A	R	D	G	Q	V	F	A	L
Secondary structure
SS confidence
Disorder																?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 33%) Beta strand ( 21%)

Rank Aligned region

PDB 6j4n chain D Region: 35 - 375 Aligned: 304 Modelled: 309 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: D: PDB Molecule:metallo-beta-lactamases pngm-1; PDBTitle: structure of papua new guinea mbl-1(pngm-1) native Phyre2 PDB 5mtz chain A Region: 59 - 375 Aligned: 294 Modelled: 303 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease z; PDBTitle: crystal structure of a long form rnase z from yeast Phyre2 PDB 2cbn chain A domain 1 Region: 61 - 375 Aligned: 298 Modelled: 315 Confidence: 100.0% Identity: 20% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: RNase Z-like Phyre2 PDB 1y44 chain A domain 1 Region: 61 - 375 Aligned: 252 Modelled: 263 Confidence: 100.0% Identity: 30% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: RNase Z-like Phyre2 PDB 3zwf chain A Region: 61 - 375 Aligned: 255 Modelled: 268 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:zinc phosphodiesterase elac protein 1; PDBTitle: crystal structure of human trnase z, short form (elac1). Phyre2 PDB 1xto chain A Region: 61 - 375 Aligned: 259 Modelled: 267 Confidence: 100.0% Identity: 16% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: Coenzyme PQQ synthesis protein B, PqqB Phyre2 PDB 3md7 chain A Region: 56 - 375 Aligned: 246 Modelled: 263 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase-like; PDBTitle: crystal structure of a beta-lactamase-like protein bound to gmp from2 brucella melitensis Phyre2 PDB 4z7r chain A Region: 61 - 375 Aligned: 252 Modelled: 261 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:coenzyme pqq synthesis protein b; PDBTitle: the 1.98-angstrom crystal structure of zn(2+)-bound pqqb from2 methylobacterium extorquens Phyre2 PDB 1zkp chain A domain 1 Region: 62 - 374 Aligned: 240 Modelled: 255 Confidence: 100.0% Identity: 19% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: YhfI-like Phyre2 PDB 1zkp chain D Region: 58 - 374 Aligned: 244 Modelled: 259 Confidence: 100.0% Identity: 18% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein ba1088; PDBTitle: 1.5a resolution crystal structure of a metallo beta lactamase family2 protein, the elac homolgue of bacillus anthracis, a putative3 ribonuclease Phyre2 PDB 2e7y chain A domain 1 Region: 77 - 375 Aligned: 232 Modelled: 237 Confidence: 100.0% Identity: 25% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: RNase Z-like Phyre2 PDB 6b9v chain A Region: 60 - 375 Aligned: 230 Modelled: 258 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase-like protein; PDBTitle: crystal structure of a new diphosphatase from the phnp family Phyre2 PDB 4ojv chain A Region: 61 - 375 Aligned: 258 Modelled: 271 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:3',5'-cyclic-nucleotide phosphodiesterase 1; PDBTitle: crystal structure of unliganded yeast pde1 Phyre2 PDB 3g1p chain A Region: 60 - 373 Aligned: 227 Modelled: 249 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:protein phnp; PDBTitle: crystals structure of phnp from e.coli k-12 Phyre2 PDB 3rpc chain D Region: 79 - 375 Aligned: 209 Modelled: 233 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: D: PDB Molecule:possible metal-dependent hydrolase; PDBTitle: the crystal structure of a possible metal-dependent hydrolase from2 veillonella parvula dsm 2008 Phyre2 PDB 2i7t chain A domain 1 Region: 61 - 375 Aligned: 250 Modelled: 265 Confidence: 99.9% Identity: 20% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: beta-CASP RNA-metabolising hydrolases Phyre2 PDB 5a0t chain A Region: 44 - 366 Aligned: 240 Modelled: 267 Confidence: 99.9% Identity: 18% PDB header:hydrolase/rna Chain: A: PDB Molecule:ribonuclease j; PDBTitle: catalysis and 5' end sensing by ribonuclease rnase j of the2 metallo-beta-lactamase family Phyre2 PDB 4qn9 chain A Region: 78 - 375 Aligned: 221 Modelled: 237 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:n-acyl-phosphatidylethanolamine-hydrolyzing phospholipase PDBTitle: structure of human nape-pld Phyre2 PDB 2az4 chain A Region: 58 - 366 Aligned: 239 Modelled: 258 Confidence: 99.9% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ef2904; PDBTitle: crystal structure of a protein of unknown function from enterococcus2 faecalis v583 Phyre2 PDB 6brm chain C Region: 79 - 375 Aligned: 217 Modelled: 235 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:putative metal-dependent isothiocyanate hydrolase saxa; PDBTitle: the crystal structure of isothiocyanate hydrolase from delia radicum2 gut bacteria Phyre2 1 c6j4nD_ 2 c5mtzA_ 3 d2cbna1 4 d1y44a1 5 c3zwfA_ 6 d1xtoa_ 7 c3md7A_ 8 c4z7rA_ 9 d1zkpa1 10 c1zkpD_ 11 d2e7ya1 12 c6b9vA_ 13 c4ojvA_ 14 c3g1pA_ 15 c3rpcD_ 16 d2i7ta1 17 c5a0tA_ 18 c4qn9A_ 19 c2az4A_ 20 c6brmC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153