1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	E	Y	D	L	E	A	V	D	K	L	P	F	S	T	P	E	K	A	Q	R	Y	Q	T	E	N	Y	R	G	A	M	G	L	N	W	Y	L	T	D	P	T	L	Q	F	I	M	A	Y	Y	L	R	P	D	E	L	A	F	A	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?		?			?		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	H	L	T	R	I	G	E	L	T	G	G	P	V	T	R	W	A	E	E	T	D	R	N	P	P	R	L	E	R	Y	D	R	W	G	H	D	I	S	R	V	V	L	P	E	S	F	I	Q	S	K	R	A	V	I	E	A	R	Q	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	R	D	D	A	A	R	A	G	V	K	P	S	L	A	L	F	A	A	D	Y	L	L	N	Q	A	D	I	G	M	A	C	A	L	A	T	G	G	N	M	V	R	S	L	V	T	A	Y	A	P	P	D	V	R	E	F	V	L	G	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	N	S	G	E	W	D	G	E	A	A	Q	L	L	T	E	R	A	G	G	S	D	L	G	A	L	E	T	T	A	T	R	S	G	D	V	W	L	L	N	G	F	K	W	F	A	S	N	C	A	G	E	A	F	V	V	L	A	K	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	G	A	P	D	S	T	R	G	V	A	T	F	L	V	L	R	T	R	R	D	G	S	R	N	G	V	R	I	R	R	L	K	D	K	L	G	T	R	S	V	A	S	G	E	I	E	F	V	D	A	E	A	F	L	L	S	G	E	P
Secondary structure
SS confidence
Disorder						?	?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	A	D	A	G	P	S	D	G	K	G	L	T	R	M	M	E	L	T	N	R	L	R	L	G	T	A	S	F	A	L	G	N	A	R	R	A	L	V	E	S	L	C	Y	A	G	Q	R	R	A	F	G	G	A	L	I	D	K	P	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		M	R	R	K	L	A	E	M	V	V	D	V	E	A	A	L	A	M	V	F	D	G	F	G	A	A	N	H	R	Q	P	R	C	L	P	Q	R	I	A	V	P	V	T	K	L	K	T	C	R	L	G	I	T	V	A	S	D	A	I	E
Secondary structure
SS confidence
Disorder																													?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		I	H	G	G	N	G	Y	I	E	T	W	P	V	A	R	L	L	R	D	A	Q	V	N	T	I	W	E	G	P	D	N	I	L	C	L	D	V	R	R	G	I	E	Q	T	R	A	H	E	T	L	L	A	R	L	R	D	A	V	S	V
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		S	D	D	D	D	T	T	R	L	V	S	R	R	I	E	D	L	D	A	A	I	T	A	W	T	K	L	D	R	Q	L	A	E	A	R	L	F	P	L	A	Q	F	M	G	D	V	Y	A	G	A	L	L	T	E	Q	A	A	W	E	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																					?		?																													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.
Sequence		A	T	R	G	T	D	R	K	A	L	V	A	R	L	Y	A	R	R	Y	L	A	D	Q	G	P	L	R	G	I	D	A	D	C	D	E	A	L	Q	R	F	D	E	L	V	A	G	A	F	T	A	E	Q	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?																					?		?	?	?																?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 55%) Beta strand ( 11%) TM helix ( 10%) (View membrane topology prediction)

Rank Aligned region

PDB 4y9l chain B Region: 13 - 590 Aligned: 560 Modelled: 578 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: B: PDB Molecule:protein acdh-11, isoform b; PDBTitle: crystal structure of caenorhabditis elegans acdh-11 Phyre2 PDB 5ez3 chain B Region: 21 - 584 Aligned: 518 Modelled: 561 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: B: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure acyl-coa dehydrogenase from brucella melitensis in2 complex with fad Phyre2 PDB 3djl chain A Region: 14 - 549 Aligned: 498 Modelled: 524 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: A: PDB Molecule:protein aidb; PDBTitle: crystal structure of alkylation response protein e. coli aidb Phyre2 PDB 6ijc chain A Region: 13 - 566 Aligned: 510 Modelled: 527 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa dehydrogenase family protein; PDBTitle: structure of mmpa-coa dehydrogenase from roseovarius nubinhibens ism Phyre2 PDB 3owa chain C Region: 50 - 560 Aligned: 474 Modelled: 487 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: C: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of acyl-coa dehydrogenase complexed with fad from2 bacillus anthracis Phyre2 PDB 2z1q chain A Region: 50 - 581 Aligned: 480 Modelled: 493 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of acyl coa dehydrogenase Phyre2 PDB 2uxw chain A Region: 51 - 560 Aligned: 472 Modelled: 489 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:very-long-chain specific acyl-coa dehydrogenase; PDBTitle: crystal structure of human very long chain acyl-coa dehydrogenase2 (acadvl) Phyre2 PDB 5ys9 chain A Region: 132 - 592 Aligned: 453 Modelled: 461 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase 3; PDBTitle: crystal structure of acyl-coa oxidase3 from yarrowia lipolytica Phyre2 PDB 5y9d chain A Region: 132 - 592 Aligned: 455 Modelled: 461 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase 1; PDBTitle: crystal structure of acyl-coa oxidase1 from yarrowia lipolytica Phyre2 PDB 5k3i chain H Region: 34 - 592 Aligned: 521 Modelled: 546 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: H: PDB Molecule:acyl-coenzyme a oxidase; PDBTitle: crystal structure of acyl-coa oxidase-1 in caenorhabditis elegans2 complexed with fad and atp Phyre2 PDB 5k3j chain A Region: 137 - 592 Aligned: 442 Modelled: 456 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase; PDBTitle: crystals structure of acyl-coa oxidase-2 in caenorhabditis elegans2 bound with fad, ascaroside-coa, and atp Phyre2 PDB 6es9 chain A Region: 53 - 462 Aligned: 375 Modelled: 389 Confidence: 100.0% Identity: 25% PDB header:flavoprotein Chain: A: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: methylsuccinyl-coa dehydrogenase of paracoccus denitrificans with2 bound flavin adenine dinucleotide Phyre2 PDB 2ddh chain A Region: 139 - 592 Aligned: 428 Modelled: 426 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa oxidase; PDBTitle: crystal structure of acyl-coa oxidase complexed with 3-oh-dodecanoate Phyre2 PDB 2fon chain A Region: 141 - 592 Aligned: 442 Modelled: 452 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:peroxisomal acyl-coa oxidase 1a; PDBTitle: x-ray crystal structure of leacx1, an acyl-coa oxidase from2 lycopersicon esculentum (tomato) Phyre2 PDB 1w07 chain A Region: 108 - 592 Aligned: 463 Modelled: 482 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa oxidase; PDBTitle: arabidopsis thaliana acyl-coa oxidase 1 Phyre2 PDB 2ix5 chain A Region: 47 - 466 Aligned: 375 Modelled: 398 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase 4, peroxisomal; PDBTitle: short chain specific acyl-coa oxidase from arabidopsis thaliana, acx42 in complex with acetoacetyl-coa Phyre2 PDB 4hr3 chain A Region: 51 - 466 Aligned: 396 Modelled: 416 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:putative acyl-coa dehydrogenase; PDBTitle: structure of a putative acyl-coa dehydrogenase from mycobacterium2 abscessus Phyre2 PDB 2pg0 chain B Region: 49 - 461 Aligned: 372 Modelled: 391 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: B: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of acyl-coa dehydrogenase from geobacillus2 kaustophilus Phyre2 PDB 1ivh chain D Region: 51 - 464 Aligned: 376 Modelled: 397 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: D: PDB Molecule:isovaleryl-coa dehydrogenase; PDBTitle: structure of human isovaleryl-coa dehydrogenase at 2.62 angstroms resolution: structural basis for substrate3 specificity Phyre2 PDB 5zw2 chain A Region: 51 - 465 Aligned: 374 Modelled: 392 Confidence: 100.0% Identity: 19% PDB header:biosynthetic protein Chain: A: PDB Molecule:l-prolyl-[peptidyl-carrier protein] dehydrogenase; PDBTitle: fad complex of piga Phyre2 1 c4y9lB_ 2 c5ez3B_ 3 c3djlA_ 4 c6ijcA_ 5 c3owaC_ 6 c2z1qA_ 7 c2uxwA_ 8 c5ys9A_ 9 c5y9dA_ 10 c5k3iH_ 11 c5k3jA_ 12 c6es9A_ 13 c2ddhA_ 14 c2fonA_ 15 c1w07A_ 16 c2ix5A_ 17 c4hr3A_ 18 c2pg0B_ 19 c1ivhD_ 20 c5zw2A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109