1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	R	V	S	L	W	L	S	V	T	A	V	A	V	L	F	G	W	G	S	W	Q	R	R	W	I	A	D	D	G	L	I	V	L	R	T	V	R	N	L	L	A	G	N	G	P	V	F	N	Q	G	E	R	V	E	A	N	T	S
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	W	T	Y	L	L	Y	V	G	G	W	V	G	G	P	M	R	L	E	Y	V	A	L	A	L	A	M	V	L	S	L	L	G	M	V	L	L	M	L	G	T	G	R	L	Y	A	P	S	L	R	G	R	R	A	I	M	L	P	A
Secondary structure
SS confidence
Disorder														?					?	?																											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	L	V	Y	I	A	V	P	P	A	R	D	F	A	T	S	G	L	E	S	G	L	V	L	A	Y	L	G	L	L	W	W	M	M	V	C	W	S	Q	P	L	R	A	R	P	D	S	Q	M	F	L	G	A	L	A	F	V	A	G
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	S	V	L	V	R	P	E	F	A	L	I	G	G	L	A	L	I	M	M	L	I	A	A	R	T	W	R	R	R	V	L	I	V	L	A	G	G	F	L	P	V	A	Y	Q	I	F	R	M	G	Y	Y	G	L	L	V	P	S	T	A
Secondary structure
SS confidence
Disorder																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	A	K	D	A	A	G	D	K	W	S	Q	G	M	I	Y	V	S	N	F	N	R	P	Y	A	L	W	V	P	L	V	L	S	V	P	L	G	L	L	L	M	T	A	R	R	R	P	S	F	L	R	P	V	L	A	P	D	Y	G	R
Secondary structure
SS confidence
Disorder				?			?	?	?	?	?	?																																		?	?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	A	R	A	V	Q	S	P	P	A	V	V	A	F	I	V	G	S	G	V	L	Q	A	L	Y	W	I	R	Q	G	G	D	F	M	H	G	R	V	L	L	A	P	L	F	C	L	L	A	P	V	G	V	I	P	I	L	L	P	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		K	D	F	S	R	E	T	G	R	W	L	V	G	A	L	S	G	L	W	L	G	I	A	G	W	S	L	W	A	A	N	S	P	G	M	G	D	D	A	T	R	V	T	Y	S	G	I	V	D	E	R	R	F	Y	A	Q	A	T	G	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	H	P	L	T	A	A	D	Y	L	D	Y	P	R	M	A	A	V	L	T	A	L	N	N	T	P	E	G	A	L	L	L	P	S	G	N	Y	N	Q	W	D	L	V	P	M	I	R	P	S	S	G	T	A	P	G	G	K	P	A	P
Secondary structure
SS confidence
Disorder																																	?					?	?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		K	P	Q	H	A	V	F	F	T	N	M	G	M	L	G	M	N	V	G	L	D	V	R	V	I	D	Q	I	G	L	V	N	P	L	A	A	H	T	E	R	L	K	H	A	R	I	G	H	D	K	N	L	F	P	D	W	V	I	A	D
Secondary structure
SS confidence
Disorder		?	?		?	?											?																				?	?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		G	P	W	V	K	W	Y	P	G	I	P	G	Y	I	D	Q	Q	W	V	T	Q	A	E	A	A	L	Q	C	P	A	T	R	A	V	L	N	S	V	R	A	P	I	T	L	H	R	F	L	S	N	V	L	H	S	Y	E	F	T	R	Y
Secondary structure
SS confidence
Disorder					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.
Sequence		R	I	D	R	V	P	R	Y	E	L	V	R	C	G	L	D	V	P	D	G	P	G	P	P	P	R	E
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 64%) Beta strand ( 3%) TM helix ( 40%) (View membrane topology prediction)

Rank Aligned region

PDB 5f15 chain A Region: 6 - 396 Aligned: 381 Modelled: 391 Confidence: 99.1% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 3waj chain A Region: 29 - 448 Aligned: 381 Modelled: 395 Confidence: 98.2% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 3rce chain A Region: 3 - 453 Aligned: 374 Modelled: 374 Confidence: 98.0% Identity: 16% PDB header:transferase/peptide Chain: A: PDB Molecule:oligosaccharide transferase to n-glycosylate proteins; PDBTitle: bacterial oligosaccharyltransferase pglb Phyre2 PDB 6p2r chain B Region: 3 - 232 Aligned: 215 Modelled: 230 Confidence: 97.4% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 2; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor Phyre2 PDB 6p25 chain A Region: 3 - 232 Aligned: 216 Modelled: 230 Confidence: 97.1% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 6ezn chain F Region: 2 - 468 Aligned: 422 Modelled: 443 Confidence: 96.4% Identity: 13% PDB header:membrane protein Chain: F: PDB Molecule:dolichyl-diphosphooligosaccharide--protein PDBTitle: cryo-em structure of the yeast oligosaccharyltransferase (ost) complex Phyre2 PDB 2d6f chain C domain 2 Region: 547 - 570 Aligned: 24 Modelled: 24 Confidence: 62.9% Identity: 21% Fold: DCoH-like Superfamily: GAD domain-like Family: GAD domain Phyre2 PDB 1zq1 chain C domain 2 Region: 548 - 570 Aligned: 23 Modelled: 23 Confidence: 58.9% Identity: 26% Fold: DCoH-like Superfamily: GAD domain-like Family: GAD domain Phyre2 PDB 4j7b chain F Region: 390 - 428 Aligned: 39 Modelled: 39 Confidence: 36.1% Identity: 26% PDB header:transferase Chain: F: PDB Molecule:205 kda microtubule-associated protein; PDBTitle: crystal structure of polo-like kinase 1 Phyre2 PDB 4j7b chain C Region: 390 - 428 Aligned: 39 Modelled: 39 Confidence: 36.1% Identity: 26% PDB header:transferase Chain: C: PDB Molecule:205 kda microtubule-associated protein; PDBTitle: crystal structure of polo-like kinase 1 Phyre2 PDB 5uz9 chain D Region: 36 - 45 Aligned: 10 Modelled: 10 Confidence: 35.3% Identity: 30% PDB header:immune system/rna Chain: D: PDB Molecule:crispr-associated protein csy3; PDBTitle: cryo em structure of anti-crisprs, acrf1 and acrf2, bound to type i-f2 crrna-guided crispr surveillance complex Phyre2 PDB 4eog chain A Region: 39 - 59 Aligned: 21 Modelled: 21 Confidence: 31.6% Identity: 24% PDB header:dna binding protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of csx1 of pyrococcus furiosus Phyre2 PDB 1usu chain A Region: 528 - 595 Aligned: 67 Modelled: 68 Confidence: 19.8% Identity: 12% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Hsp90 middle domain Phyre2 PDB 1s4n chain A Region: 549 - 579 Aligned: 31 Modelled: 31 Confidence: 19.0% Identity: 19% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Glycolipid 2-alpha-mannosyltransferase Phyre2 PDB 1s4p chain A Region: 549 - 579 Aligned: 31 Modelled: 31 Confidence: 17.9% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:glycolipid 2-alpha-mannosyltransferase; PDBTitle: crystal structure of yeast alpha1,2-mannosyltransferase kre2p/mnt1p:2 ternary complex with gdp/mn and methyl-alpha-mannoside acceptor Phyre2 PDB 1g8f chain A domain 2 Region: 428 - 501 Aligned: 60 Modelled: 74 Confidence: 17.9% Identity: 22% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: ATP sulfurylase catalytic domain Phyre2 PDB 2prr chain A domain 1 Region: 529 - 607 Aligned: 73 Modelled: 79 Confidence: 17.6% Identity: 7% Fold: AhpD-like Superfamily: AhpD-like Family: Atu0492-like Phyre2 PDB 2gx8 chain B Region: 580 - 606 Aligned: 27 Modelled: 27 Confidence: 17.2% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:nif3-related protein; PDBTitle: the crystal structure of bacillus cereus protein related to nif3 Phyre2 PDB 5ve9 chain C Region: 327 - 334 Aligned: 8 Modelled: 8 Confidence: 16.9% Identity: 50% PDB header:protein binding Chain: C: PDB Molecule:microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; PDBTitle: structure of hacf7 ef1-ef2-gar domains Phyre2 PDB 1ht6 chain A domain 1 Region: 525 - 542 Aligned: 18 Modelled: 18 Confidence: 16.8% Identity: 17% Fold: Glycosyl hydrolase domain Superfamily: Glycosyl hydrolase domain Family: alpha-Amylases, C-terminal beta-sheet domain Phyre2 1 c5f15A_ 2 c3wajA_ 3 c3rceA_ 4 c6p2rB_ 5 c6p25A_ 6 c6eznF_ 7 d2d6fc2 8 d1zq1c2 9 c4j7bF_ 10 c4j7bC_ 11 c5uz9D_ 12 c4eogA_ 13 d1usua_ 14 d1s4na_ 15 c1s4pA_ 16 d1g8fa2 17 d2prra1 18 c2gx8B_ 19 c5ve9C_ 20 d1ht6a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99