1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	A	V	Q	S	A	L	V	D	R	P	G	M	L	A	T	A	R	G	L	S	H	F	G	E	H	C	I	G	W	L	I	L	A	L	L	G	A	I	A	L	P	R	R	R	R	E	W	L	V	A	G	A	G	A	F	V	A	H
Secondary structure
SS confidence
Disorder		?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	I	A	V	L	I	K	R	L	V	R	R	Q	R	P	D	H	P	A	I	A	V	N	V	D	T	P	S	Q	L	S	F	P	S	A	H	A	T	S	T	T	A	A	A	L	L	M	G	R	A	T	G	L	P	L	P	V	V	L	V
Secondary structure
SS confidence
Disorder																												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.
Sequence		P	P	M	A	L	S	R	I	L	L	G	V	H	Y	P	S	D	V	A	V	G	V	A	L	G	A	T	V	G	A	I	V	D	S	V	G	G	G	R	Q	R	A	R	K	R
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 62%) (View membrane topology prediction)

Rank Aligned region

PDB 5jki chain A Region: 2 - 163 Aligned: 156 Modelled: 162 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:putative lipid phosphate phosphatase yodm; PDBTitle: crystal structure of the first transmembrane pap2 type2 phosphatidylglycerolphosphate phosphatase from bacillus subtilis Phyre2 PDB 6ebu chain A Region: 4 - 154 Aligned: 145 Modelled: 151 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:lpxe; PDBTitle: crystal structure of aquifex aeolicus lpxe Phyre2 PDB 4px7 chain A Region: 11 - 165 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylglycerophosphatase; PDBTitle: crystal structure of lipid phosphatase e. coli pgpb Phyre2 PDB 2akc chain C Region: 10 - 152 Aligned: 143 Modelled: 143 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:class a nonspecific acid phosphatase phon; PDBTitle: crystal structure of tungstate complex of the phon protein from s.2 typhimurium Phyre2 PDB 1d2t chain A Region: 9 - 154 Aligned: 146 Modelled: 146 Confidence: 99.9% Identity: 16% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Type 2 phosphatidic acid phosphatase, PAP2 Phyre2 PDB 4usz chain A Region: 47 - 163 Aligned: 117 Modelled: 117 Confidence: 99.7% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:vanadium-dependent haloperoxidase; PDBTitle: crystal structure of the first bacterial vanadium dependant2 iodoperoxidase Phyre2 PDB 3w36 chain A Region: 47 - 161 Aligned: 115 Modelled: 115 Confidence: 99.3% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:naph1; PDBTitle: crystal structure of holo-type bacterial vanadium-dependent2 chloroperoxidase Phyre2 PDB 1qi9 chain A Region: 63 - 154 Aligned: 92 Modelled: 92 Confidence: 98.8% Identity: 32% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Haloperoxidase (bromoperoxidase) Phyre2 PDB 1vng chain A Region: 47 - 145 Aligned: 99 Modelled: 99 Confidence: 98.6% Identity: 29% PDB header:haloperoxidase Chain: A: PDB Molecule:vanadium chloroperoxidase; PDBTitle: chloroperoxidase from the fungus curvularia inaequalis: mutant h404a Phyre2 PDB 1vns chain A Region: 47 - 145 Aligned: 99 Modelled: 99 Confidence: 98.6% Identity: 30% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Chloroperoxidase Phyre2 PDB 1up8 chain A Region: 71 - 154 Aligned: 84 Modelled: 84 Confidence: 98.3% Identity: 27% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Haloperoxidase (bromoperoxidase) Phyre2 PDB 5lpc chain A Region: 71 - 154 Aligned: 84 Modelled: 84 Confidence: 98.3% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:vanadium-dependent bromoperoxidase; PDBTitle: crystal structure of vanadium-dependent haloperoxidase from a. marina Phyre2 PDB 1qhb chain A Region: 63 - 154 Aligned: 92 Modelled: 92 Confidence: 98.3% Identity: 23% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Haloperoxidase (bromoperoxidase) Phyre2 PDB 5aa6 chain F Region: 55 - 154 Aligned: 100 Modelled: 100 Confidence: 98.2% Identity: 20% PDB header:oxidoreductase Chain: F: PDB Molecule:vanadium-dependent bromoperoxidase 2; PDBTitle: homohexameric structure of the second vanadate-dependent2 bromoperoxidase (anii) from ascophyllum nodosum Phyre2 PDB 3pt3 chain A Region: 64 - 97 Aligned: 28 Modelled: 34 Confidence: 17.8% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase ubr5; PDBTitle: crystal structure of the c-terminal lobe of the human ubr5 hect domain Phyre2 PDB 2mom chain B Region: 138 - 164 Aligned: 27 Modelled: 27 Confidence: 16.6% Identity: 22% PDB header:membrane protein Chain: B: PDB Molecule:lysosome-associated membrane glycoprotein 2; PDBTitle: structural insights of tm domain of lamp-2a in dpc micelles Phyre2 PDB 2mom chain C Region: 138 - 164 Aligned: 27 Modelled: 27 Confidence: 16.6% Identity: 22% PDB header:membrane protein Chain: C: PDB Molecule:lysosome-associated membrane glycoprotein 2; PDBTitle: structural insights of tm domain of lamp-2a in dpc micelles Phyre2 PDB 1p58 chain F Region: 4 - 40 Aligned: 37 Modelled: 37 Confidence: 16.0% Identity: 16% PDB header:virus Chain: F: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 1p58 chain E Region: 4 - 40 Aligned: 37 Modelled: 37 Confidence: 16.0% Identity: 16% PDB header:virus Chain: E: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 2mic chain A Region: 138 - 164 Aligned: 26 Modelled: 27 Confidence: 9.9% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 1 c5jkiA_ 2 c6ebuA_ 3 c4px7A_ 4 c2akcC_ 5 d1d2ta_ 6 c4uszA_ 7 c3w36A_ 8 d1qi9a_ 9 c1vngA_ 10 d1vnsa_ 11 d1up8a_ 12 c5lpcA_ 13 d1qhba_ 14 c5aa6F_ 15 c3pt3A_ 16 c2momB_ 17 c2momC_ 18 c1p58F_ 19 c1p58E_ 20 c2micA_ 21 22 23 24 25 26 27 28 29 30