1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	T	V	V	I	V	A	W	I	A	N	R	P	P	A	S	S	H	E	P	S	P	T	P	N	T	Q	L	A	E	Q	P	L	I	G	L	G	G	G	V	T	V	R	E	L	T	Q	D	T	P	F	S	L	V	A	L	T	G
Secondary structure
SS confidence
Disorder		?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?				?	?	?	?	?	?	?	?	?		?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	L	A	G	T	S	A	R	V	R	A	K	R	P	D	G	D	W	G	P	W	Y	Q	T	E	Y	E	T	E	P	R	D	P	A	G	T	D	G	S	V	E	L	G	G	L	N	P	G	P	R	S	T	D	P	V	F	V	G	T	T
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	T	V	Q	V	A	V	T	R	P	I	D	A	P	I	T	Q	P	P	A	G	R	P	P	N	D	L	L	D	S	G	L	G	Y	R	P	A	T	K	E	Q	P	F	G	Q	N	I	S	A	I	L	I	S	P	P	Q	A	P	P	G
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	Q	W	T	P	P	T	A	V	T	M	A	G	Q	P	P	A	I	I	S	R	A	E	W	G	A	D	E	S	L	R	C	E	T	P	E	Y	D	R	G	V	R	A	A	V	V	H	H	T	A	G	S	N	D	Y	S	P	L	E	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?													?	?	?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	G	I	V	K	A	I	Y	T	Y	H	S	K	T	L	G	W	C	D	I	A	Y	N	A	L	V	D	K	Y	G	Q	V	F	E	G	S	A	G	G	L	T	K	P	V	E	G	F	H	T	G	G	F	N	R	N	T	W	G	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		M	I	G	N	F	D	D	V	A	P	T	P	I	Q	I	R	T	V	G	R	L	L	G	W	R	L	G	M	D	D	V	D	P	R	S	M	V	D	L	Q	S	A	G	S	S	Y	T	T	F	P	G	G	A	I	A	R	L	P	A	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		F	T	H	R	D	V	G	N	T	D	C	P	G	N	A	A	Y	A	V	M	D	E	I	R	D	I	A	A	H	F	N	D	P	P	E	E	L	I	K	A	L	E	G	G	A	I	Y	Q	R	W	Q	A	L	G	G	M	N	S	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	A	P	T	S	P	E	A	D	A	A	D	G	A	R	Y	A	T	F	A	K	G	A	M	Y	W	S	P	V	T	D	A	Q	P	I	T	G	A	I	Y	E	A	W	A	S	Q	S	Y	E	R	G	P	L	G	L	P	T	S	A	E
Secondary structure
SS confidence
Disorder							?																																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.
Sequence		I	Q	E	P	L	Q	I	T	Q	N	F	Q	H	G	T	L	N	F	E	R	L	T	G	N	V	T	E	V	V	D	G	I	T	T	P	L	A	T	R	P	P	S	G	P	T	V	P	P	E	H	F	T	L	P	T	H	P	I	T
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 11%) Beta strand ( 21%)

Rank Aligned region

PDB 4z8i chain A Region: 180 - 380 Aligned: 172 Modelled: 178 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan recognition protein 3; PDBTitle: crystal structure of branchiostoma belcheri tsingtauense peptidoglycan2 recognition protein 3 Phyre2 PDB 1sxr chain A Region: 195 - 385 Aligned: 162 Modelled: 168 Confidence: 100.0% Identity: 31% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 1s2j chain A Region: 195 - 384 Aligned: 161 Modelled: 167 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan recognition protein sa cg11709-pa; PDBTitle: crystal structure of the drosophila pattern-recognition2 receptor pgrp-sa Phyre2 PDB 6ckh chain A Region: 197 - 394 Aligned: 169 Modelled: 175 Confidence: 100.0% Identity: 24% PDB header:immune system Chain: A: PDB Molecule:peptidoglycan-recognition protein; PDBTitle: manduca sexta peptidoglycan recognition protein-1 Phyre2 PDB 5xz3 chain D Region: 197 - 385 Aligned: 160 Modelled: 166 Confidence: 100.0% Identity: 25% PDB header:immune system Chain: D: PDB Molecule:peptidoglycan-recognition protein; PDBTitle: the x-ray structure of apis mellifera pgrp-sa Phyre2 PDB 2cb3 chain A domain 1 Region: 195 - 382 Aligned: 160 Modelled: 165 Confidence: 100.0% Identity: 28% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 2rkq chain A Region: 197 - 384 Aligned: 160 Modelled: 165 Confidence: 100.0% Identity: 28% PDB header:immune system Chain: A: PDB Molecule:peptidoglycan-recognition protein-sd; PDBTitle: crystal structure of drosophila peptidoglycan recognition2 protein sd (pgrp-sd) Phyre2 PDB 3ep1 chain B Region: 195 - 382 Aligned: 153 Modelled: 160 Confidence: 100.0% Identity: 29% PDB header:immune system Chain: B: PDB Molecule:pgrp-hd - peptidoglycan recognition protein PDBTitle: structure of the pgrp-hd from alvinella pompejana Phyre2 PDB 2f2l chain A domain 1 Region: 198 - 382 Aligned: 156 Modelled: 162 Confidence: 100.0% Identity: 26% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 1yck chain A domain 1 Region: 195 - 382 Aligned: 159 Modelled: 158 Confidence: 100.0% Identity: 35% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 2f2l chain X domain 1 Region: 198 - 382 Aligned: 157 Modelled: 158 Confidence: 100.0% Identity: 28% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 2xz4 chain A Region: 197 - 382 Aligned: 158 Modelled: 163 Confidence: 100.0% Identity: 29% PDB header:immune system Chain: A: PDB Molecule:peptidoglycan-recognition protein lf; PDBTitle: crystal structure of the lfz ectodomain of the2 peptidoglycan recognition protein lf Phyre2 PDB 1oht chain A Region: 197 - 382 Aligned: 157 Modelled: 163 Confidence: 100.0% Identity: 24% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 1oht chain A Region: 197 - 382 Aligned: 157 Modelled: 163 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:cg14704 protein; PDBTitle: peptidoglycan recognition protein-lb Phyre2 PDB 1sk4 chain A Region: 196 - 382 Aligned: 156 Modelled: 163 Confidence: 100.0% Identity: 31% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 6fhg chain B Region: 198 - 383 Aligned: 148 Modelled: 163 Confidence: 100.0% Identity: 22% PDB header:antimicrobial protein Chain: B: PDB Molecule:lyst endolysin; PDBTitle: crystal structure of the ts2631 endolysin from thermus scotoductus2 phage with the unique n-terminal moiety responsible for peptidoglycan3 anchoring Phyre2 PDB 2xz8 chain A Region: 197 - 334 Aligned: 125 Modelled: 138 Confidence: 100.0% Identity: 18% PDB header:immune system Chain: A: PDB Molecule:peptidoglycan-recognition protein lf; PDBTitle: crystal structure of the lfw ectodomain of the2 peptidoglycan recognition protein lf Phyre2 PDB 1lba chain A Region: 219 - 388 Aligned: 134 Modelled: 139 Confidence: 100.0% Identity: 28% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 2bgx chain A domain 2 Region: 198 - 380 Aligned: 149 Modelled: 159 Confidence: 99.9% Identity: 16% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 1yb0 chain A domain 1 Region: 215 - 389 Aligned: 139 Modelled: 151 Confidence: 99.9% Identity: 14% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 1 c4z8iA_ 2 d1sxra_ 3 c1s2jA_ 4 c6ckhA_ 5 c5xz3D_ 6 d2cb3a1 7 c2rkqA_ 8 c3ep1B_ 9 d2f2la1 10 d1ycka1 11 d2f2lx1 12 c2xz4A_ 13 d1ohta_ 14 c1ohtA_ 15 d1sk4a_ 16 c6fhgB_ 17 c2xz8A_ 18 d1lbaa_ 19 d2bgxa2 20 d1yb0a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99