1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	R	L	V	L	L	R	H	G	Q	S	Y	G	N	V	E	R	R	L	D	T	L	P	P	G	T	A	L	T	P	L	G	R	D	Q	A	R	A	F	A	R	S	G	C	R	R	P	A	L	L	A	H	S	V	A	I	R	A
Secondary structure
SS confidence
Disorder		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	Q	T	A	A	V	V	A	A	E	L	D	M	V	A	H	E	V	A	G	I	H	E	V	Q	V	G	E	L	E	N	R	N	D	D	E	A	V	A	E	F	N	A	T	Y	S	R	W	H	R	G	E	L	D	V	P	L	P	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	T	A	N	D	V	L	D	R	Y	L	P	V	L	A	D	L	R	M	R	Y	L	D	D	G	D	W	D	G	D	I	V	V	V	S	H	S	A	A	I	R	L	A	A	A	V	L	A	G	V	D	G	N	F	V	L	D	N	H	L
Secondary structure
SS confidence
Disorder																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.
Sequence		E	N	V	E	S	V	V	L	A	P	I	T	D	G	R	W	S	C	V	Q	W	G	L	R	K	P	P	F	C	P	D	P	A	E	A	A	A	S	P	V	T	H	A	V	T	S	S	T	D	P	M	G
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 39%) Beta strand ( 13%) TM helix ( 7%) (View membrane topology prediction)

Rank Aligned region

PDB 4ij5 chain B Region: 1 - 207 Aligned: 199 Modelled: 207 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:phosphoserine phosphatase 1; PDBTitle: crystal structure of a novel-type phosphoserine phosphatase from2 hydrogenobacter thermophilus tk-6 Phyre2 PDB 1e58 chain A Region: 4 - 219 Aligned: 211 Modelled: 216 Confidence: 100.0% Identity: 20% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 5vve chain A Region: 1 - 196 Aligned: 192 Modelled: 193 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: A: PDB Molecule:phosphoglycerate mutase; PDBTitle: crystal structure of phosphoglycerate mutase from naegleria fowleri Phyre2 PDB 1k6m chain A Region: 2 - 231 Aligned: 215 Modelled: 230 Confidence: 100.0% Identity: 20% PDB header:transferase, hydrolase Chain: A: PDB Molecule:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2- PDBTitle: crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2,2 6-bisphosphatase Phyre2 PDB 1bif chain A Region: 2 - 231 Aligned: 215 Modelled: 230 Confidence: 100.0% Identity: 20% PDB header:bifunctional enzyme Chain: A: PDB Molecule:6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; PDBTitle: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bifunctional2 enzyme complexed with atp-g-s and phosphate Phyre2 PDB 1xq9 chain A Region: 1 - 206 Aligned: 201 Modelled: 205 Confidence: 100.0% Identity: 22% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 3f3k chain A Region: 1 - 201 Aligned: 200 Modelled: 201 Confidence: 100.0% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ykr043c; PDBTitle: the structure of uncharacterized protein ykr043c from saccharomyces2 cerevisiae. Phyre2 PDB 4emb chain D Region: 4 - 196 Aligned: 189 Modelled: 193 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: D: PDB Molecule:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; PDBTitle: crystal structure of a phosphoglycerate mutase gpma from borrelia2 burgdorferi b31 Phyre2 PDB 1yjx chain D Region: 2 - 195 Aligned: 190 Modelled: 194 Confidence: 100.0% Identity: 26% PDB header:isomerase, hydrolase Chain: D: PDB Molecule:phosphoglycerate mutase 1; PDBTitle: crystal structure of human b type phosphoglycerate mutase Phyre2 PDB 4pz9 chain B Region: 2 - 204 Aligned: 198 Modelled: 203 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:glucosyl-3-phosphoglycerate phosphatase; PDBTitle: the native structure of mycobacterial glucosyl-3-phosphoglycerate2 phosphatase rv2419c Phyre2 PDB 3ll4 chain B Region: 1 - 194 Aligned: 193 Modelled: 194 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein ykr043c; PDBTitle: structure of the h13a mutant of ykr043c in complex with fructose-1,6-2 bisphosphate Phyre2 PDB 1fzt chain A Region: 2 - 196 Aligned: 191 Modelled: 194 Confidence: 100.0% Identity: 23% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1rii chain A Region: 2 - 195 Aligned: 190 Modelled: 194 Confidence: 100.0% Identity: 25% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1h2e chain A Region: 2 - 207 Aligned: 199 Modelled: 206 Confidence: 100.0% Identity: 20% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1bif chain A domain 2 Region: 5 - 231 Aligned: 212 Modelled: 227 Confidence: 100.0% Identity: 19% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain Phyre2 PDB 2i1v chain B Region: 2 - 194 Aligned: 178 Modelled: 191 Confidence: 100.0% Identity: 21% PDB header:transferase, hydrolase Chain: B: PDB Molecule:6-phosphofructo-2-kinase/fructose-2,6- PDBTitle: crystal structure of pfkfb3 in complex with adp and2 fructose-2,6-bisphosphate Phyre2 PDB 1qhf chain A Region: 4 - 195 Aligned: 188 Modelled: 192 Confidence: 100.0% Identity: 26% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 5um0 chain A Region: 1 - 196 Aligned: 192 Modelled: 194 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: A: PDB Molecule:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; PDBTitle: crystal structure of 2,3-bisphosphoglycerate-dependent2 phosphoglycerate mutase from neisseria gonorrhoeae Phyre2 PDB 2hhj chain A domain 1 Region: 4 - 195 Aligned: 187 Modelled: 192 Confidence: 100.0% Identity: 24% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 5zkk chain A Region: 1 - 208 Aligned: 197 Modelled: 208 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:phosphoglycerate mutase family protein, putative; PDBTitle: crystal structure of phosphoserine phosphatase from entamoeba2 histolytica Phyre2 1 c4ij5B_ 2 d1e58a_ 3 c5vveA_ 4 c1k6mA_ 5 c1bifA_ 6 d1xq9a_ 7 c3f3kA_ 8 c4embD_ 9 c1yjxD_ 10 c4pz9B_ 11 c3ll4B_ 12 d1fzta_ 13 d1riia_ 14 d1h2ea_ 15 d1bifa2 16 c2i1vB_ 17 d1qhfa_ 18 c5um0A_ 19 d2hhja1 20 c5zkkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99