1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	Q	V	C	S	Q	C	G	T	G	W	N	V	R	E	R	Q	R	V	W	C	P	R	C	R	G	M	L	L	A	P	L	A	D	M	P	A	E	A	R	W	R	T	P	A	R	P	Q	V	P	T	A	S	D	T	R	R	T	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?						?	?				?																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	R	L	P	P	G	F	R	W	I	A	V	R	P	G	A	A	P	P	P	R	H	G	P	R	L	R	G	P	T	P	R	Y	A	G	I	P	R	W	G	L	T	D	H	V	D	Q	A	P	V	P	A	S	A	K	A	G	P	S	P
Secondary structure
SS confidence
Disorder		?	?												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	V	R	T	T	L	L	V	S	L	L	V	F	S	I	A	V	V	V	F	V	V	R	Y	V	L	L	V	I	N	R	N	T	L	L	N	S	V	V	A	S	A	S	V	W	L	G	V	L	V	S	L	A	A	I	A	A	A	G
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	T	I	V	L	L	V	R	W	L	V	A	R	R	A	A	A	F	M	H	Q	G	L	P	E	R	R	S	A	R	E	L	W	A	G	C	L	L	P	M	V	N	L	L	W	A	P	L	Y	V	I	E	L	A	L	V	E	D	R	Y
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?																												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	R	L	R	R	P	I	V	V	W	W	I	V	W	I	V	S	N	A	I	S	M	F	A	F	A	T	S	W	V	T	D	A	Q	G	I	A	N	N	T	T	M	M	V	L	A	Y	L	C	A	A	A	A	V	A	A	A	A	R	V
Secondary structure
SS confidence
Disorder		?	?	?	?																							?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.
Sequence		F	E	G	F	E	Q	K	P	V	E	R	P	A	H	R	W	V	V	V	N	T	D	G	R	S	A	P	A	S	S	V	A	V	E	L	D	G	Q	E	P	A	A
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?	?							?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 39%) Alpha helix ( 49%) Beta strand ( 5%) TM helix ( 33%) (View membrane topology prediction)

Rank Aligned region

PDB 2kdx chain A Region: 5 - 28 Aligned: 24 Modelled: 24 Confidence: 54.2% Identity: 17% PDB header:metal-binding protein Chain: A: PDB Molecule:hydrogenase/urease nickel incorporation protein PDBTitle: solution structure of hypa protein Phyre2 PDB 1fft chain G Region: 153 - 233 Aligned: 81 Modelled: 81 Confidence: 51.3% Identity: 11% PDB header:oxidoreductase Chain: G: PDB Molecule:ubiquinol oxidase; PDBTitle: the structure of ubiquinol oxidase from escherichia coli Phyre2 PDB 2gmg chain A domain 1 Region: 5 - 33 Aligned: 29 Modelled: 29 Confidence: 41.3% Identity: 21% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: PF0610-like Phyre2 PDB 4nl6 chain C Region: 15 - 91 Aligned: 77 Modelled: 77 Confidence: 41.2% Identity: 12% PDB header:splicing Chain: C: PDB Molecule:survival motor neuron protein; PDBTitle: structure of the full-length form of the protein smn found in healthy2 patients Phyre2 PDB 1ee8 chain A domain 3 Region: 3 - 26 Aligned: 24 Modelled: 24 Confidence: 40.4% Identity: 33% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: C-terminal, Zn-finger domain of MutM-like DNA repair proteins Phyre2 PDB 1k3x chain A domain 3 Region: 3 - 26 Aligned: 24 Modelled: 24 Confidence: 38.5% Identity: 33% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: C-terminal, Zn-finger domain of MutM-like DNA repair proteins Phyre2 PDB 2fiy chain A domain 1 Region: 5 - 25 Aligned: 18 Modelled: 21 Confidence: 36.5% Identity: 39% Fold: FdhE-like Superfamily: FdhE-like Family: FdhE-like Phyre2 PDB 1tdz chain A domain 3 Region: 3 - 26 Aligned: 24 Modelled: 24 Confidence: 35.7% Identity: 38% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: C-terminal, Zn-finger domain of MutM-like DNA repair proteins Phyre2 PDB 1fft chain B domain 2 Region: 162 - 239 Aligned: 77 Modelled: 78 Confidence: 30.8% Identity: 6% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 1l1t chain A domain 3 Region: 3 - 26 Aligned: 24 Modelled: 24 Confidence: 30.3% Identity: 42% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: C-terminal, Zn-finger domain of MutM-like DNA repair proteins Phyre2 PDB 1r2z chain A domain 3 Region: 3 - 26 Aligned: 24 Modelled: 24 Confidence: 30.1% Identity: 42% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: C-terminal, Zn-finger domain of MutM-like DNA repair proteins Phyre2 PDB 1k82 chain A domain 3 Region: 3 - 26 Aligned: 24 Modelled: 24 Confidence: 29.9% Identity: 29% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: C-terminal, Zn-finger domain of MutM-like DNA repair proteins Phyre2 PDB 6agf chain B Region: 166 - 201 Aligned: 36 Modelled: 36 Confidence: 26.0% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:sodium channel subunit beta-1; PDBTitle: structure of the human voltage-gated sodium channel nav1.4 in complex2 with beta1 Phyre2 PDB 2gb5 chain B Region: 5 - 35 Aligned: 31 Modelled: 31 Confidence: 25.3% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:nadh pyrophosphatase; PDBTitle: crystal structure of nadh pyrophosphatase (ec 3.6.1.22) (1790429) from2 escherichia coli k12 at 2.30 a resolution Phyre2 PDB 5zb8 chain B Region: 5 - 51 Aligned: 47 Modelled: 47 Confidence: 23.5% Identity: 30% PDB header:dna binding protein Chain: B: PDB Molecule:pfuendoq; PDBTitle: crystal structure of the novel lesion-specific endonuclease pfuendoq2 from pyrococcus furiosus Phyre2 PDB 6ok1 chain B Region: 1 - 31 Aligned: 28 Modelled: 31 Confidence: 23.3% Identity: 36% PDB header:transport protein Chain: B: PDB Molecule:chsh2(duf35); PDBTitle: ltp2-chsh2(duf35) aldolase Phyre2 PDB 5mg5 chain W Region: 1 - 31 Aligned: 28 Modelled: 31 Confidence: 23.1% Identity: 18% PDB header:transferase Chain: W: PDB Molecule:2,4-diacetylphloroglucinol biosynthesis protein; PDBTitle: a multi-component acyltransferase phlabc from pseudomonas protegens2 soaked with the monoacetylphloroglucinol (mapg) Phyre2 PDB 3cng chain C Region: 5 - 33 Aligned: 29 Modelled: 29 Confidence: 21.4% Identity: 31% PDB header:hydrolase Chain: C: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from nitrosomonas europaea Phyre2 PDB 4rku chain I Region: 217 - 233 Aligned: 17 Modelled: 17 Confidence: 20.7% Identity: 29% PDB header:photosynthesis Chain: I: PDB Molecule:photosystem i reaction center subunit viii; PDBTitle: crystal structure of plant photosystem i at 3 angstrom resolution Phyre2 PDB 2gnr chain A domain 1 Region: 1 - 31 Aligned: 28 Modelled: 31 Confidence: 20.3% Identity: 25% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: SSO2064-like Phyre2 1 c2kdxA_ 2 c1fftG_ 3 d2gmga1 4 c4nl6C_ 5 d1ee8a3 6 d1k3xa3 7 d2fiya1 8 d1tdza3 9 d1fftb2 10 d1l1ta3 11 d1r2za3 12 d1k82a3 13 c6agfB_ 14 c2gb5B_ 15 c5zb8B_ 16 c6ok1B_ 17 c5mg5W_ 18 c3cngC_ 19 c4rkuI_ 20 d2gnra1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99