1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	A	A	T	L	L	S	L	G	A	V	F	L	A	E	L	G	D	R	S	Q	L	I	T	M	T	Y	T	L	R	Y	R	W	W	V	V	L	T	G	V	A	I	A	A	F	T	V	H	G	V	A	V	A	I	G	H	F	L	G
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	T	V	P	A	R	P	A	A	C	V	S	A	I	A	F	L	I	F	A	V	W	V	W	R	E	D	T	A	S	D	S	E	T	S	P	T	A	A	E	P	R	L	A	L	F	T	V	V	S	S	F	A	L	A	E	L	G	D	K
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	T	L	A	T	V	T	L	A	S	D	H	H	W	A	G	V	W	I	G	T	T	L	G	M	I	L	A	D	G	L	A	I	G	A	G	L	L	L	H	R	R	L	P	E	R	L	L	Q	V	L	T	G	L	L	F	L	L	F	G
Secondary structure
SS confidence
Disorder											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	W	L	L	F	D	D	A	L	G	F	R	S	V	A	I	A	V	T	A	A	V	V	L	A	A	A	T	T	A	V	S	V	R	V	A	Q	T	R	R	R	R	P	T	A	A	A	T	P	E	D	D	S	T	R	P	E	R	S	S
Secondary structure
SS confidence
Disorder									?					?																								?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	A	P	G	H	P	G	S	I	L	L	P	L	P	E	V	S	L	R	G	R	R	P	P	S	G	S	P	D	E	R	C	A	D	P	G	S	K	G	G	S	R	R	I	S	V	G	C	W	L	P	G	V	G	R	I	R	P	T	R
Secondary structure
SS confidence
Disorder		?	?	?												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?															?	?	?	?	?
Disorder confidence
		.	.
Sequence		S	S
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 62%) Beta strand ( 3%) TM helix ( 40%) (View membrane topology prediction)

Rank Aligned region

PDB 5vkv chain A Region: 35 - 193 Aligned: 157 Modelled: 159 Confidence: 95.7% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccda; PDBTitle: solution nmr structure of the membrane electron transporter ccda Phyre2 PDB 6mjp chain F Region: 23 - 88 Aligned: 66 Modelled: 66 Confidence: 63.8% Identity: 11% PDB header:lipid transport Chain: F: PDB Molecule:fig000988: predicted permease; PDBTitle: lptb(e163q)fgc from vibrio cholerae Phyre2 PDB 5x5y chain G Region: 23 - 87 Aligned: 65 Modelled: 65 Confidence: 56.6% Identity: 17% PDB header:membrane protein Chain: G: PDB Molecule:uncharacterized protein; PDBTitle: a membrane protein complex Phyre2 PDB 5x5y chain F Region: 23 - 85 Aligned: 63 Modelled: 63 Confidence: 53.0% Identity: 10% PDB header:membrane protein Chain: F: PDB Molecule:uncharacterized protein; PDBTitle: a membrane protein complex Phyre2 PDB 5l75 chain G Region: 23 - 85 Aligned: 63 Modelled: 63 Confidence: 44.3% Identity: 14% PDB header:transport protein Chain: G: PDB Molecule:fig000906: predicted permease; PDBTitle: a protein structure Phyre2 PDB 3hd6 chain A Region: 138 - 216 Aligned: 75 Modelled: 79 Confidence: 44.2% Identity: 20% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg Phyre2 PDB 6mjp chain G Region: 23 - 85 Aligned: 63 Modelled: 63 Confidence: 44.0% Identity: 16% PDB header:lipid transport Chain: G: PDB Molecule:lps export abc transporter permease lptg; PDBTitle: lptb(e163q)fgc from vibrio cholerae Phyre2 PDB 5ze3 chain B Region: 236 - 289 Aligned: 40 Modelled: 54 Confidence: 36.2% Identity: 40% PDB header:oxidoreductase Chain: B: PDB Molecule:lysyl oxidase homolog 2; PDBTitle: crystal structure of human lysyl oxidase-like 2 (hloxl2) in a2 precursor state Phyre2 PDB 5l75 chain F Region: 23 - 85 Aligned: 63 Modelled: 63 Confidence: 35.9% Identity: 6% PDB header:transport protein Chain: F: PDB Molecule:fig000988: predicted permease; PDBTitle: a protein structure Phyre2 PDB 5aez chain A Region: 138 - 217 Aligned: 80 Modelled: 80 Confidence: 31.1% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:mep2; PDBTitle: crystal structure of candida albicans mep2 Phyre2 PDB 5a43 chain B Region: 35 - 163 Aligned: 119 Modelled: 129 Confidence: 30.3% Identity: 9% PDB header:transport protein Chain: B: PDB Molecule:putative fluoride ion transporter crcb; PDBTitle: crystal structure of a dual topology fluoride ion channel. Phyre2 PDB 1mxa chain A domain 1 Region: 240 - 250 Aligned: 11 Modelled: 11 Confidence: 30.0% Identity: 55% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 2p02 chain A domain 1 Region: 240 - 250 Aligned: 11 Modelled: 11 Confidence: 28.5% Identity: 55% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1qm4 chain A domain 1 Region: 240 - 250 Aligned: 11 Modelled: 11 Confidence: 28.3% Identity: 55% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1ei5 chain A domain 2 Region: 278 - 290 Aligned: 13 Modelled: 13 Confidence: 28.1% Identity: 62% Fold: Streptavidin-like Superfamily: D-aminopeptidase, middle and C-terminal domains Family: D-aminopeptidase, middle and C-terminal domains Phyre2 PDB 2e74 chain F domain 1 Region: 1 - 14 Aligned: 14 Modelled: 14 Confidence: 27.9% Identity: 57% Fold: Single transmembrane helix Superfamily: PetM subunit of the cytochrome b6f complex Family: PetM subunit of the cytochrome b6f complex Phyre2 PDB 4mby chain B Region: 263 - 300 Aligned: 38 Modelled: 38 Confidence: 23.5% Identity: 24% PDB header:viral protein Chain: B: PDB Molecule:major capsid protein vp1; PDBTitle: structure of b-lymphotropic polyomavirus vp1 in complex with 3'-2 sialyllactose Phyre2 PDB 5aex chain J Region: 138 - 217 Aligned: 72 Modelled: 80 Confidence: 21.3% Identity: 13% PDB header:membrane protein Chain: J: PDB Molecule:ammonium transporter mep2; PDBTitle: crystal structure of saccharomyces cerevisiae mep2 Phyre2 PDB 5vn4 chain A Region: 264 - 287 Aligned: 24 Modelled: 24 Confidence: 19.5% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:adenine phosphoribosyltransferase, putative; PDBTitle: crystal structure of adenine phosphoribosyl transferase from2 trypanosoma brucei in complex with amp, pyrophosphate, and ribose-5-3 phosphate Phyre2 PDB 3c1i chain A Region: 138 - 224 Aligned: 76 Modelled: 87 Confidence: 18.1% Identity: 25% PDB header:transport protein Chain: A: PDB Molecule:ammonia channel; PDBTitle: substrate binding, deprotonation and selectivity at the periplasmic2 entrance of the e. coli ammonia channel amtb Phyre2 1 c5vkvA_ 2 c6mjpF_ 3 c5x5yG_ 4 c5x5yF_ 5 c5l75G_ 6 c3hd6A_ 7 c6mjpG_ 8 c5ze3B_ 9 c5l75F_ 10 c5aezA_ 11 c5a43B_ 12 d1mxaa1 13 d2p02a1 14 d1qm4a1 15 d1ei5a2 16 d2e74f1 17 c4mbyB_ 18 c5aexJ_ 19 c5vn4A_ 20 c3c1iA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87