1

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10

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20

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30

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40

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50

.

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.

60

Sequence

V

T

W

L

A

D

P

V

G

N

S

R

I

A

R

A

Q

A

C

K

T

S

I

S

A

P

I

V

E

S

W

R

A

Q

R

G

A

Q

C

G

Q

R

E

K

S

C

R

C

S

R

A

V

H

I

Q

G

I

S

P

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

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.

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.

70

.

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.

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.

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80

.

.

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.

.

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90

.

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.

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.

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.

100

.

.

.

.

.

.

.

.

Sequence

L

F

R

R

P

L

E

P

A

V

Q

A

A

V

A

S

C

R

L

G

R

H

P

V

V

A

H

R

V

T

V

A

L

G

Q

G

S

Q

L

A

Q

R

E

C

P

R

P

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 42%) Alpha helix ( 57%) Beta strand ( 13%)

Rank Aligned region

PDB 1qb3 chain B Region: 61 - 75 Aligned: 15 Modelled: 15 Confidence: 10.3% Identity: 53% PDB header:cell cycle Chain: B: PDB Molecule:cyclin-dependent kinases regulatory subunit; PDBTitle: crystal structure of the cell cycle regulatory protein cks1 Phyre2 PDB 1t3q chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 8.7% Identity: 33% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 2v51 chain E Region: 55 - 61 Aligned: 7 Modelled: 7 Confidence: 8.4% Identity: 86% PDB header:structural protein/contractile protein Chain: E: PDB Molecule:mkl/myocardin-like protein 1; PDBTitle: structure of mal-rpel1 complexed to actin Phyre2 PDB 2v51 chain F Region: 55 - 61 Aligned: 7 Modelled: 7 Confidence: 8.1% Identity: 86% PDB header:structural protein/contractile protein Chain: F: PDB Molecule:mkl/myocardin-like protein 1; PDBTitle: structure of mal-rpel1 complexed to actin Phyre2 PDB 5e8j chain C Region: 24 - 31 Aligned: 8 Modelled: 8 Confidence: 7.8% Identity: 75% PDB header:translation Chain: C: PDB Molecule:rnmt-activating mini protein; PDBTitle: crystal structure of mrna cap guanine-n7 methyltransferase in complex2 with ram Phyre2 PDB 1jro chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 7.7% Identity: 33% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 1v97 chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 7.5% Identity: 40% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 1rm6 chain C domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 7.3% Identity: 27% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 1zxi chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 7.0% Identity: 40% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 1dgj chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 6.4% Identity: 40% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 2gxb chain A domain 1 Region: 45 - 64 Aligned: 20 Modelled: 20 Confidence: 6.3% Identity: 20% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Z-DNA binding domain Phyre2 PDB 1n62 chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 6.2% Identity: 40% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 2qkd chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 6.2% Identity: 50% PDB header:signaling protein, cell cycle Chain: A: PDB Molecule:zinc finger protein zpr1; PDBTitle: crystal structure of tandem zpr1 domains Phyre2 PDB 1ffv chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 6.2% Identity: 33% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 1vlb chain A domain 1 Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 5.5% Identity: 47% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 1qbj chain C Region: 45 - 64 Aligned: 20 Modelled: 20 Confidence: 5.4% Identity: 20% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Z-DNA binding domain Phyre2 PDB 1t3q chain D Region: 26 - 40 Aligned: 15 Modelled: 15 Confidence: 5.3% Identity: 33% PDB header:oxidoreductase Chain: D: PDB Molecule:quinoline 2-oxidoreductase small subunit; PDBTitle: crystal structure of quinoline 2-oxidoreductase from pseudomonas2 putida 86 Phyre2 PDB 2kct chain A Region: 52 - 64 Aligned: 13 Modelled: 13 Confidence: 5.3% Identity: 31% PDB header:chaperone Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccme; PDBTitle: solution nmr structure of the ob-fold domain of heme2 chaperone ccme from desulfovibrio vulgaris. northeast3 structural genomics target dvr115g. Phyre2 1 c1qb3B_ 2 d1t3qa1 3 c2v51E_ 4 c2v51F_ 5 c5e8jC_ 6 d1jroa1 7 d1v97a1 8 d1rm6c1 9 d1zxia1 10 d1dgja1 11 d2gxba1 12 d1n62a1 13 c2qkdA_ 14 d1ffva1 15 d1vlba1 16 d1qbjc_ 17 c1t3qD_ 18 c2kctA_